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GTPBP1 is upregulated by interferon-gamma and encodes a protein that is a member of the AGP11/GTPBP1 family of GTP-binding proteins. Zusätzlich bieten wir Ihnen GTP Binding Protein 1 Kits (8) und GTP Binding Protein 1 Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Here, we show that the human protein GBP1 (zeige GBP1 Antikörper) acts as a cytosolic "glue trap," capturing cytosolic Gram-negative bacteria through a unique protein motif and preventing disseminated infections in cell culture models. To escape from this GBP1 (zeige GBP1 Antikörper)-mediated host defense, Shigella employs a virulence factor that prevents or dislodges the association of GBP1 (zeige GBP1 Antikörper) with cytosolic bacteria.
Results show that GBP1 (zeige GBP1 Antikörper) is overexpressed in triple-negative breast cancer (TNBC), under the control of EGFR (zeige EGFR Antikörper) and selectively affects the growth of TNBC cell lines.
These findings confirm the involvement of caspase-1 (zeige CASP1 Antikörper) in non-classical secretion mechanisms and open novel perspectives for the extracellular function of secreted GBP-1 (zeige GBP1 Antikörper).
Taken together, these results provide a new understanding of the antiviral mechanism of human GBP1 (zeige GBP1 Antikörper), which possesses potent anti-Kaposi's sarcoma-associated herpesvirus activity, and suggest the critical role of viral RTA (zeige RBM9 Antikörper) in the evasion of the innate immune response during primary infection by Kaposi's sarcoma-associated herpesvirus.
Elevated hGBP-1 RNA in ovarian tumors correlates with shorter recurrence-free survival. hGBP-1 does not confer paclitaxel resistance on MCF-7 and TMX2-28 breast cancer cells.
In insulitic islets from living patients with recent-onset T1D, most of the overexpressed ISGs, including GBP1 (zeige GBP1 Antikörper), TLR3 (zeige TLR3 Antikörper), OAS1 (zeige OAS1 Antikörper), EIF2AK2 (zeige EIF2AK2 Antikörper), HLA-E (zeige HLAE Antikörper), IFI6 (zeige IFI6 Antikörper), and STAT1 (zeige STAT1 Antikörper), showed higher expression in the islet core compared with the peri (zeige PLIN1 Antikörper)-islet area containing the surrounding immune cells
the study not only highlights the importance of hGBP1 tetramer in stimulated GMP (zeige NT5C2 Antikörper) formation, but also demonstrates its role in the antiviral activity against hepatitis C virus.
GBP1 (zeige GBP1 Antikörper) expression is elevated in human Glioblastoma multiforme tumors and positively correlates with EGFRvIII status in Glioblastoma multiforme specimens, and its expression is inversely correlated with the survival rate of Glioblastoma multiforme patients. Taken together, these results reveal that GBP1 (zeige GBP1 Antikörper) may serve as a potential therapeutic target for Glioblastoma multiforme with EGFRvIII mutation.
GBP1 (zeige GBP1 Antikörper) promotes lymph node metastasis and has a positive correlation with EGFR (zeige EGFR Antikörper) expression in esophageal squamous cell carcinoma.
Molecular dynamics studies showed that only GTP (zeige AK3 Antikörper) decreases the formation of the GBP1 (zeige GBP1 Antikörper):PIM1 (zeige PIM1 Antikörper) complex through an allosteric mechanism, outlining the rational for the identification of new compounds potentially able to revert resistance to paclitaxel.
Guanylate binding protein expression is induced by interferon. Guanylate binding proteins are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.
, GTP-binding protein 1
, GTP binding protein 1
, GTP-binding protein 1-like
, guanine nucleotide-binding protein 1
, guanylate binding protein 1, interferon-inducible, 67kDa
, interferon-induced guanylate-binding protein 1