GATA Binding Protein 6 (GATA6) ELISA Kits

GATA6 is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. Zusätzlich bieten wir Ihnen GATA6 Antikörper (122) und GATA6 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
GATA6 2627 Q92908
GATA6 14465 Q61169
GATA6 29300 P46153
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Anmelden zum Anzeigen 11 bis 18 Tage

Weitere ELISA Kits für GATA6 Interaktionspartner

Human GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. Study shows that GATA Binding Protein 6 (GATA6) alone is essential but not sufficient for estrogen formation in endometriosis. However, simultaneous addition of GATA6 and nuclear receptor subfamily 5, group A, member to an endometrial stromal cell is sufficient to transform it into an endometriotic-like cell, manifested by the activation of the estradiol biosynthetic cascade.

  2. GATA-binding protein 6 (GATA6), whose expression can be inversely regulated by miR-455 in CRC cell lines.

  3. High GATA6 expression is associated with gastric cancer.

  4. The long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. A number of angiogenesis- and hypoxia-related genes were downregulated by GATA6-AS silencing.

  5. High GATA6 expression is associated with Gastric Cancer.

  6. Increased GATA6 expression is associated with laryngeal squamous cell carcinoma.

  7. These findings suggest that GATA6 might interact with HNF4alpha and contribute to the development of mucinous-type lung adenocarcinomas

  8. Genetic variants in GATA6 gene had severe pancreatic atrophy but with abundant beta cells and severe amyloidosis similar to type 2 diabetes.

  9. Study firstly associates GATA6 loss-of-function mutation with increased susceptibility to familial congenital bicuspid aortic valve (BAV) in humans, which provides novel insight into the molecular pathogenesis underlying BAV.

  10. although relatively infrequent in patients with hypertrophic cardiomyopathy, GATA2, 4 and 6 transcription factors may represent a novel insight into the molecular mechanisms related to the pathogenesis of hypertrophic cardiomyopathy

  11. loss of one GATA6 allele affects the differentiation of pancreatic progenitors from the early PDX1+ stage to the more mature PDX1+NKX6.1+ stage, leading to impaired formation of glucose-responsive beta-like cells; in addition to this GATA6 haploinsufficiency, also identified dosage-sensitive requirements for GATA6 and GATA4 in the formation of both definitive endoderm and pancreatic progenitor cells

  12. Results show that GATA6 protein levels are reduced in tissue samples from colon cancer patients with miR-196b upregulation and that GATA6 is a direct target of miR-196b.

  13. Our data suggested that miR-124 decreases GATA6 expression by targeting its 3'-UTR, which in turn inhibits cholangiocarcinoma invasion and metastasis.

  14. Gain-of-function mutations in GATA6 in both a family with early-onset Atrial Fibrillation and Atrioventricular Septal Defects was found.

  15. analysis of the TNF-insulin signaling with GATA6 reveals specific patterns of gene expression in cells receiving multiple stimuli

  16. These data show that GATA6 plays a critical role in endoderm and pancreas specification and beta-like cell functionality in humans.

  17. GATA6 variant frequency in sporadic CTDs patients was higher than that in other congenital heart diseases.

  18. Knockdown of GATA6 completely eliminated the effect of TCF1, while forced expression of GATA6 induced hESC differentiation

  19. In human Pancreatic Ductal Adenocarcinoma cells, GATA6 inhibits de-differentiation and epithelial-mesenchymal transition both directly and indirectly, through mechanism that involves the regulation of transcription factors, including FOXA1/2.Loss of GATA6 in PDAC primary samples is associated with altered differentiation and shorter overall patient survival.

  20. GATA6 induces expression of genes essential for growth of colon cancer cells under adherent conditions (REG4) and genes required for their clonogenicity (LGR5), and miR-363-GATA6-REG4/LGR5 signaling cascade promotes tumorigenicity of colon cancer cells.

Mouse (Murine) GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. The long non-coding antisense transcript of GATA6 (GATA6-AS) interacts with the epigenetic regulator LOXL2 to regulate endothelial gene expression via changes in histone methylation. A number of angiogenesis- and hypoxia-related genes were downregulated by GATA6-AS silencing. Silencing of GATA6-AS diminishes TGF-beta2-induced endothelial-mesenchymal transition in vitro and promotes formation of blood vessels in mice.

  2. Gata6 could be utilized as a biomarker to select the best Pluripotent stem cell (PSC) lines to produce PSC-derived cardiomyocytes.

  3. GATA4/6 are key regulators of steroidogenesis and testicular somatic cell survival.

  4. Phosphorylation of GATA6 by Erk1/2 compels exit from pluripotent state, and the phosphorylation propels a GATA6 positive feedback regulatory circuit to compel primitive endoderm differentiation

  5. These findings identify Gata6-directed differentiation of neural crest to vascular smooth muscle cells as an essential mechanism that specifies the aortic tree, and provide a new framework for how mutations in GATA6 lead to congenital heart disorders in humans.

  6. Data (including data from studies in knockout mice and transgenic mice) suggest that pancreatic islets in adult mice deficient in GATA6 activity exhibit decreased insulin content and impaired insulin secretion. Gata6-deficient mice are apparently normal at birth; as they age they develop glucose intolerance.

  7. results support a model in which Gata6 contributes to repression of Isl1 expression in the anterior of nascent hindlimb buds.

  8. these findings indicated that the downregulation of GATA-6 effectively inhibited airway inflammation and reversed airway remodeling via Cav-1

  9. During wound healing differentiated Gata6(+) cells migrate from the sebaceous duct into the interfollicular epidermis and dedifferentiate, acquiring the ability to undergo long-term self-renewal and differentiate into a much wider range of epidermal lineages than in undamaged tissue.

  10. The authors find that Gata6 protects against DNA damage associated with proliferation, thus preventing cell cycle arrest and apoptosis.

  11. Findings indicate that the Gata6 promoter is activated by Esrrb in association with Ncoa3, and Dax1 inhibited activities of Esrrb and Ncoa3, resulting maintenance of the undifferentiated status of embryonic stem (ES) cells.

  12. GATA4 and GATA6 are essential for female fertility, whereas targeting either factor alone causes subfertility. GATA4 and GATA6 are also required for the expression of the receptors for prolactin and luteinizing hormone.

  13. GATA4/6-mediated inhibition of hedgehog signaling is a major mechanism regulating pancreatic endoderm specification during patterning of the gut tube

  14. In the pancreas, Gata6 acts as a tumour suppressor by enforcing acinar cell differentiation, by directly and indirectly repressing ectopic differentiation programmes, and by regulating crucial cancer-related gene expression pathways.

  15. The role of GATA4 in the regulation of cardiomyocyte maturation in the newborn heart and in maintaining diastolic function in the adult heart.

  16. Our results, for the first time, portray a pivotal role of GATA6 in regulating metastatic behaviors of breast cancer cells

  17. data indicated that GATA-6 and Akt2 are involved in the mTORC1-mediated regulation of VSMC proliferation and differentiation.

  18. GATA6 contributes to the development and postnatal function of the murine atrioventricular node by promoting cell-cycle exit of specified cardiomyocytes toward a conduction system lineage.

  19. Gata6 is a versatile and potent reprograming factor that can act alone to drive a cell fate switch from diverse cell types

  20. Mice with double deletion of Gata4 and Gata6 lack identifiable adrenal glands. Inactivation of Gata6 alone drastically reduced the adrenal size and corticosterone production in the adult animals.

Xenopus laevis GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. Data show that GATA4 or 6 regulate both cardiogenic potential and subsequent cardiomyocyte differentiation but that GATA5 is involved in regulating cardiomyocyte differentiation.

  2. Results describe the expression of GATA4 and 6 during gastrulation and their function in migratory behaviour.

  3. several transcription factors, that is SRF, myocardin, and GATA6, that induce the expression of SM-MHC in animal cap cells

Zebrafish GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. these data suggest an essential role for Pak1 as an Erk activator, and Gata6 as an Erk target, during neural crest development.

  2. specification of cardiac fate downstream of gata5/6 involves activation of the tmem88a gene to constrain WNT signaling and expand the number of cardiac progenitors.

  3. in zebrafish the gata6 genes are redundant for specification of cardiomyocytes.

  4. Results suggest that GATA4 and -6 play a key role in the regulation of ventricular myosin heavy chain gene expression in the ventricle.

Pig (Porcine) GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. investigation of genes regulated by GATA6, GATA4, and both in combination: studies in granulosa cells primed for luteinization

  2. The altered ratio of GATA4 to GATA6 after ovulation may allow GATA6 to enhance STAR mRNA accumulation.

Cow (Bovine) GATA Binding Protein 6 (GATA6) Interaktionspartner

  1. GATA4 and GATA6 mRNA and proteins could be detected in bovine corpus luteum (CL). GATA6 showed a marked decrease at the regressed luteal stage, like NR5A1, NR5A2, and the other steroidogenic markers.

GATA6 Antigen-Profil

Beschreibung des Gens

This gene is a member of a small family of zinc finger transcription factors that play an important role in the regulation of cellular differentiation and organogenesis during vertebrate development. This gene is expressed during early embryogenesis and localizes to endo- and mesodermally derived cells during later embryogenesis and thereby plays an important role in gut, lung, and heart development. Mutations in this gene are associated with several congenital defects.

Genbezeichner und Symbole assoziert mit GATA6

  • GATA binding protein 6 (GATA6) Antikörper
  • GATA binding protein 6 (Gata6) Antikörper
  • GATA binding protein 6 (gata6) Antikörper
  • GATA binding protein 6 L homeolog (gata6.L) Antikörper
  • AA410133 Antikörper
  • cb603 Antikörper
  • GATA-5 Antikörper
  • gata-6 Antikörper
  • gata6 Antikörper
  • gata6a Antikörper
  • gata6b Antikörper
  • pnr Antikörper
  • tGata6 Antikörper
  • XGATA-6 Antikörper
  • XGATA6 Antikörper

Bezeichner auf Proteinebene für GATA6

GATA-binding factor 6 , transcription factor GATA-6 , GATA-binding protein 6 , DNA-binding protein GATA-GT2 , zinc-finger transcription factor Gata6 , GATA-6 transcription factor , GATA-binding factor 6-B , transcription factor xGATA-6B , GATA binding protein 6 , transcription factor GATA-6-like , GATA-6 , LOW QUALITY PROTEIN: transcription factor GATA-6 , transcription factor GATA6

2627 Homo sapiens
14465 Mus musculus
29300 Rattus norvegicus
395062 Xenopus (Silurana) tropicalis
396390 Gallus gallus
399082 Xenopus laevis
490520 Canis lupus familiaris
100228783 Taeniopygia guttata
100434852 Pongo abelii
58076 Danio rerio
397600 Sus scrofa
654400 Bos taurus
100720264 Cavia porcellus
468495 Pan troglodytes
100820751 Ovis aries musimon
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