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The protein encoded by FOXK2 contains a fork head DNA binding domain. Zusätzlich bieten wir Ihnen Forkhead Box K2 Antikörper (69) und viele weitere Produktgruppen zu diesem Protein an.
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FOXK2, regulted by miR (zeige MLXIP Proteine)-1271-5p, promotes cell growth and indicates unfavorable prognosis in hepatocellular carcinoma
SOX9 (zeige SOX9 Proteine) transcriptionally activated FOXK2 was involved in the pathogenesis of colorectal cancer.FOXK2 is highly expressed in colorectal cancer tissues.
Results show that Foxk2 expression was downregulated in lung adenocarcinoma tissues and non-small cell lung cancer cell (NSCLC) lines. Its overexpression suppresses epithelial-mesenchymal transition in NSCLC cells and inhibits cell migration and invasion. Also, the expression of Foxk2 seems to be regulated by miR (zeige MLXIP Proteine)-1271.
FOXO3 (zeige FOXO3 Proteine)-dependent gene regulation is generally mediated not through uniquely bound regions but through regions occupied by both FOXK2 and FOXO3 (zeige FOXO3 Proteine) where both factors play a regulatory role.
FOXK2 might act as a negative regulator of ERalpha (zeige ESR1 Proteine), and its association with both ERalpha (zeige ESR1 Proteine) and BRCA1/BARD1 (zeige BARD1 Proteine) could lead to the down-regulation of ERalpha (zeige ESR1 Proteine) transcriptional activity, effectively regulating the function of ERalpha (zeige ESR1 Proteine).
FOXK1 and FOXK2 positively regulate Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by translocating dishevelled (zeige DVL2 Proteine) proteins into the nucleus.
BAP1 (zeige RNF2 Proteine) deficiency causes increased expression of FoxK2 target genes in a Ring1B (zeige RNF2 Proteine)-Bmi1 (zeige BMI1 Proteine)-dependent manner
FOXK2 can promote transcriptional activation and is required for the efficient recruitment of AP-1 (zeige FOSB Proteine) components to chromatin.
Data show that FOXK2 is subject to control by cell cycle-regulated hyperphosphorylation occurring in CDK (zeige CDK4 Proteine)).cyclin (zeige PCNA Proteine)-dependent manner with CDK1 (zeige CDK1 Proteine).cyclin B as the major kinase complex.
FOXK2 is a G/T-mismatch DNA-binding protein (zeige UBE2V1 Proteine) and a deaminated DNA-binding protein (zeige UBE2V1 Proteine)
FoxK2 is required for proliferation and survival.
Foxk1 and Foxk2 are identified as transcriptional repressors of autophagy in muscle cells and fibroblasts.
The protein encoded by this gene contains a fork head DNA binding domain. This protein can bind to the purine-rich motifs of the HIV long terminal repeat (LTR), and to the similar purine-rich motif in the interleukin 2 (IL2) promoter. It may be involved in the regulation of viral and cellular promoter elements.
, cellular transcription factor ILF-1
, forkhead box protein K2
, interleukin enhancer binding factor 1
, interleukin enhancer-binding factor 1
, forkhead box K2