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FSCN1 encodes a member of the fascin family of actin-binding proteins. Zusätzlich bieten wir Ihnen Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Antikörper (215) und Fascin Homolog 1, Actin-Bundling Protein (Strongylocentrotus Purpuratus) Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human FSCN1 ELISA Kit für Sandwich ELISA - ABIN414808
Teng, Xu, Yue, Ma, Zhang, Zhao, Guo, Zhang, Gu, Wang: Serological investigation of the clinical significance of fascin in non-small-cell lung cancer. in Lung cancer (Amsterdam, Netherlands) 2013
Alterations in nuclear Fascin levels result in defects in nucleolar morphology in both Drosophila follicles and cultured mammalian cells, suggesting that nuclear Fascin plays an important role in nucleolar architecture.
essential for actin bundle initiation and stiffening during embryonic tracheal system development
Fascin and Ena cooperate to extend and maintain robust filopodia of uniform thickness with aligned barbed ends by a unique mechanistic cycle.
Fascin links Btl/FGFR signalling to the actin cytoskeleton during Drosophila tracheal morphogenesis.
These data lead to the conclusion that prostaglandins regulate Fascin to control actin remodeling
The terminal branchlets of different classes of neurons have distinctive dynamics and are formed on the basis of molecularly separable mechanisms; in particular, class III neurons require fascin for terminal branching whereas class IV neurons do not.
The regulatory role of FascinS52 appears to be tissuespecific, and its importance might depend on the dynamics and the turnover rate of actin bundles between various cell types.
Fascin deficiency does not impair 20-hydroxyecdysone response, but neurites fail to maintain their normal, nearly straight trajectory, instead forming curls and hooks. This is accompanied by abnormally distributed filamentous actin.
Fascin is required for plasmatocyte migration, both as these cells undergo developmental dispersal and during an inflammatory response to epithelial wounding.
study found that Rab35 (zeige RAB35 ELISA Kits) regulates the assembly of actin (zeige ACTB ELISA Kits) filaments during bristle development; effect was mediated by the a (zeige ACTB ELISA Kits)ctin-bundling protein fascin, which directly associated with active R (zeige RAB35 ELISA Kits)ab35
These data show that fscn1a-dependent filopodia are required in a subset of NC cells to promote cell migration and NC derivative formation
Filopodia formation by crosslinking of F-actin with fascin in two different binding manners
Fascin-1 expression, cadherin-17 expression, tumor size, and differentiation were independent risk factors for GC.
Fascin1 facilitates phagolysosomal fusion for killing of phagocytosed Listeria. It binds to LC3 (zeige MAP1LC3A ELISA Kits), an autophagosome marker, both in vivo & in vitro. It plays a critical role in dendritic cell survivalduring Listeria infection.
A tightly regulated phospho/dephospho-fascin cycle modulated by extracellular signals is required for the polarized morphology and migration in neuroblasts, thus contributing to efficient neurogenesis.
fascin 1 promotes cell migration and has a role in growth and cell cycle progression
Suppression of fascin expression results in reduction of activation-induced migration and invasion in mouse monocytic leukemia RAW264.7 macrophages.
Both STAT3 (zeige STAT3 ELISA Kits) and NFkappaB are required for the cytokine-induced expression of fascin in cancer cells.
fascin-1 is principally expressed in neural and mesenchymal derivatives during embryonic development
We propose that fascin is a key specific actin cross-linker, providing stiffness for filopodial bundles, and that its dynamic behavior allows for efficient coordination between elongation and bundling of filopodial actin filaments.
Fascin is a novel target of beta-catenin (zeige CTNNB1 ELISA Kits)-TCF (zeige HNF4A ELISA Kits) signaling and is expressed at the invasive front of human colon cancer
SNAI2 overexpression significantly increased FSCN1 expression at both mRNA and protein level. FSCN1 overexpression reduced the expression of E-cadherin (zeige CDH1 ELISA Kits) and Claudin 1 (zeige CLDN7 ELISA Kits), but increased the expression of Vimentin (zeige VIM ELISA Kits) and N-cadherin (zeige CDH2 ELISA Kits) in SCC9 and SCC (zeige CYP11A1 ELISA Kits)-15 cells. It is inferred that FSCN1 is a downstream effector of SNAI2 in promoting EMT (zeige ITK ELISA Kits) in HNSC cells.
MYC (zeige MYC ELISA Kits)-nick, fascin, and Cdc42 (zeige CDC42 ELISA Kits) are frequently up-regulated in cells present at the invasive front of human colorectal tumors, suggesting a coordinated role for these proteins in tumor migration.
The prognostic importance of TGF-beta (zeige TGFB1 ELISA Kits), TGF-beta (zeige TGFB1 ELISA Kits) receptor, and fascin in childhood solid tumors
The results reveal that phosphorylation at FSCN1 amino acids Y23, S38, S39 and S274, in combination, downregulates the extent of anchorage-independent growth, cell migration and filopodia formation in esophageal squamous cancer cells.
Fascin and alpha-actinin intrinsically segregate to discrete bundled domains that are specifically recognized by other actin-binding proteins.
This study showed that fascin expression intensity may be correlated with clinical outcomes of a newly diagnosed primary glioblastoma.
These data demonstrated fascin as a critical regulator of breast cancer stem cell pool at least partially via activation of the Notch (zeige NOTCH1 ELISA Kits) self-renewal signaling pathway.
These results suggest that strong positive fascin-1 expression can be used as a diagnostic marker of TNBC.
Authors demonstrated that one miRNA, miR (zeige MLXIP ELISA Kits)-29a-5p, can bind to both the XIAP (zeige XIAP ELISA Kits) and FSCN1 3'UTRs and play an important role in that interactions. We showed that the 3'UTR (zeige UTS2R ELISA Kits) of XIAP (zeige XIAP ELISA Kits) was able to antagonize miR (zeige MLXIP ELISA Kits)-29a-5p, and resulted in the increased translation of XIAP (zeige XIAP ELISA Kits) and FSCN1.
The expression of fascin-1 and lanminin-5 and the serum levels of fascin-1 and laminin-5 were related to the relapse of patients with non-small cell lung cancer.
FSCN1 gene plays an in prenatal skeletal muscle development and was a candidate gene for meat production trait.
This gene encodes a member of the fascin family of actin-binding proteins. Fascin proteins organize F-actin into parallel bundles, and are required for the formation of actin-based cellular protrusions. The encoded protein plays a critical role in cell migration, motility, adhesion and cellular interactions. Expression of this gene is known to be regulated by several microRNAs, and overexpression of this gene may play a role in the metastasis of multiple types of cancer by increasing cell motility. Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma. A pseudogene of this gene is located on the long arm of chromosome 15.
, fascin 1
, singed-like protein
, 55 kDa actin-bundling protein
, singed-like (fascin homolog, sea urchin)