F-Box Protein 31 Proteine (FBXO31)

Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. Zusätzlich bieten wir Ihnen F-Box Protein 31 Antikörper (62) und F-Box Protein 31 Kits (12) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
FBXO31 76454 Q3TQF0
FBXO31 79791 Q5XUX0
FBXO31 498959 B2RYN2
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Top F-Box Protein 31 Proteine auf antikoerper-online.de

Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$547.80
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,439.33
Details

FBXO31 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,
Rat (Rattus)

Weitere Proteine zu F-Box Protein 31 (FBXO31) Interaktionspartnern

Human F-Box Protein 31 (FBXO31) Interaktionspartner

  1. Results identified FBXO31 as a novel E3 ubiquitin ligase of Snail1, and its low expression contributes to an aberrant accumulation of Snail1 in gastric cancer. Furthermore, F-box domain of FBXO31 and the phosphorylation of Snail1 are essential for the interaction and degradation. These findings reveal the important function of FBXO31 on the regulation of Snail1 protein level in gastric cancer.

  2. results reveal how alterations in FBXO31 phosphorylation, mediated by AKT and ATM, underlie physiological regulation of FBXO31 levels in unstressed and genotoxically stressed cells

  3. Findings indicate the substrate specificity of the F-box protein FBXO31 and the mechanism of FBXO31-regulated cyclin D1 protein turnover.

  4. FBXO31 targets and ubiquitylates Slug for proteasomal degradation. However, this mechanism is repressed in breast tumors where miR-93 and miR-106a are overexpressed. Our study further unravels an interesting mechanism whereby Slug drives the expression of miR-93 and miR-106a, thus establishing a positive feedback loop to maintain an invasive phenotype

  5. in addition to revealing that FBXO31 is an independent prognostic marker for esophageal squamous cell carcinoma , our findings substantiate a novel regulatory role of FBXO31 in tumorigenesis and drug resistance of esophageal squamous cell carcinoma

  6. Expression of FBXO31 inhibited xenograft tumor growth in mice. miR-20a and miR-17 mimics inhibited, whereas the inhibitor of miR-20a and miR-17 increased, the expression of FBXO31, respectively. miR-20a and miR-17 directly bind to the 3'-UTR of FBXO31.

  7. FBXO31-mediated loss of MDM2 leads to elevated levels of p53, resulting in growth arrest. In cells depleted of FBXO31, MDM2 is not degraded and p53 levels do not increase following genotoxic stress

  8. uncover a new mechanism of deactivation of MKK6-p38 and substantiate a novel regulatory role of FBXO31 in stress response

  9. FBXO31 interacts with Cdt1 and regulates the degradation of Cdt1 in G2 phase.

  10. Truncation of the E3 ubiquitin ligase component FBXO31 causes non-syndromic autosomal recessive intellectual disability.

  11. ascribe a role for FBXO31 in dendrite growth and neuronal migration in the developing cerebellar cortex. Taken together, we uncovered the centrosomal E3 ligase FBXO31-SCF as a novel regulator of neuronal development

  12. The Skp2 SCF complex, not TRAF6, is a critical E3 ligase for ErbB-receptor-mediated Akt ubiquitination and membrane recruitment in response to EGF.

  13. CGH array indicated that cases having cyclin D1 with increased copy number were significantly associated with elevated FBXO31 expression levels (P<0.05). FBXO31 could be a novel and robust prognostic marker for ESCC.

  14. Loss of FBXO31 is associated with breast cancer

  15. ectopic expression of FBXO31 acts through a proteasome-directed pathway to mediate the degradation of cyclin D1, an important regulator of progression from G1 to S phase, resulting in arrest in G1

F-Box Protein 31 (FBXO31) Protein Überblick

Protein Überblick

Members of the F-box protein family, such as FBXO31, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1\; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004

Genbezeichner und Symbole assoziert mit F-Box Protein 31 Proteine (FBXO31)

  • F-box protein 31 (Fbxo31)
  • F-box protein 31 (FBXO31)
  • F-box protein 31 (fbxo31)
  • F-box protein 31 S homeolog (fbxo31.S)
  • 1110003O08Rik Protein
  • 2310046N15Rik Protein
  • fbx14 Protein
  • fbx31 Protein
  • fbxo14 Protein
  • fbxo31 Protein
  • pp2386 Protein
  • RGD1561069 Protein

Bezeichner auf Proteinebene für F-Box Protein 31 Proteine (FBXO31)

F-box only protein 14 , F-box only protein 31 , SCF ubiquitin ligase specificity factor , putative breast cancer tumor-suppressor , F-box protein 31 , F-box only protein 31-A , F-box only protein 31-like , f-box only protein 31-like

GENE ID SPEZIES
76454 Mus musculus
79791 Homo sapiens
415828 Gallus gallus
454297 Pan troglodytes
479620 Canis lupus familiaris
498959 Rattus norvegicus
513951 Bos taurus
695313 Macaca mulatta
779980 Xenopus (Silurana) tropicalis
100018330 Monodelphis domestica
100037115 Xenopus laevis
100070571 Equus caballus
100077592 Ornithorhynchus anatinus
100349211 Oryctolagus cuniculus
100409588 Callithrix jacchus
100444670 Pongo abelii
100512607 Sus scrofa
100601426 Nomascus leucogenys
101104521 Ovis aries
100726050 Cavia porcellus
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