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EYA2 encodes a member of the eyes absent (EYA) family of proteins.
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Eya2 in a physical complex with Six1 (zeige SIX1 Proteine) plays a critical role in physiological hypertrophy.
Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo
Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt (zeige AKT1 Proteine)/mTOR (zeige FRAP1 Proteine) signaling pathway.
our data indicate that Eya2 may serve as a potential oncoprotein in human astrocytoma. Eya2 regulates astrocytoma cell proliferation and invasion, possibly through the regulation of ERK (zeige EPHB2 Proteine) signaling.
EYA2 knockdown led to decreased metastatic spread of breast cancer cells to the lung and greatly attenuated the ability of EGFR (zeige EGFR Proteine) to regulate the epithelial-to-mesenchymal transition markers.
High EYA2 expression is associated with acute myeloid leukemia (zeige BCL11A Proteine).
EYA2 functions as a stimulant in lung adenocarcinoma pathogenesis.
results demonstrate that overexpression of miR (zeige MLXIP Proteine)-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression
SIX1 (zeige SIX1 Proteine) and EYA are often co-overexpressed in tumors, and the SIX1 (zeige SIX1 Proteine)-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model.
Decreased expression of EYA2 is associated with pancreatic adenocarcinomas.
This interaction suggests that CDK6 (zeige CDK6 Proteine) regulates EYA2 activity, a mechanism that could be important in development and in cancer.
MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration.
Functional roles of candidate genes EYA2 (20q13) and hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines.
This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.
eyes absent 2
, eyes absent homolog 2
, eyes absent homolog 2 (Drosophila)
, Drosophila-type eyes absent 2-like protein
, eyes absent 2 homolog