Eyes Absent Homolog 2 (Drosophila) Proteine (EYA2)

EYA2 encodes a member of the eyes absent (EYA) family of proteins. Zusätzlich bieten wir Ihnen EYA2 Antikörper (75) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
EYA2 14049 O08575
EYA2 2139 O00167
Ratte EYA2 EYA2 156826  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
Escherichia coli (E. coli) Human His-SUMO Tag 100 μg Anmelden zum Anzeigen 11 Days
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage

EYA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu Eyes Absent Homolog 2 (Drosophila) (EYA2) Interaktionspartnern

Mouse (Murine) Eyes Absent Homolog 2 (Drosophila) (EYA2) Interaktionspartner

  1. Eya2 in a physical complex with Six1 plays a critical role in physiological hypertrophy.

  2. Eya2 protein is required for hypaxial somitic myogenesis in the mouse embryo

  3. Eya2 prevents adverse cardiac remodeling under pressure overload partly through altering metabolic gene expression and preserving PI3K/Akt/mTOR signaling pathway.

Human Eyes Absent Homolog 2 (Drosophila) (EYA2) Interaktionspartner

  1. our data indicate that Eya2 may serve as a potential oncoprotein in human astrocytoma. Eya2 regulates astrocytoma cell proliferation and invasion, possibly through the regulation of ERK signaling.

  2. EYA2 knockdown led to decreased metastatic spread of breast cancer cells to the lung and greatly attenuated the ability of EGFR to regulate the epithelial-to-mesenchymal transition markers.

  3. High EYA2 expression is associated with acute myeloid leukemia.

  4. EYA2 functions as a stimulant in lung adenocarcinoma pathogenesis.

  5. results demonstrate that overexpression of miR-30a in lung adenocarcinoma A549 cells can inhibit cell migration and invasion, which is partially attributed to the decrease of EYA2 expression

  6. SIX1 and EYA are often co-overexpressed in tumors, and the SIX1-EYA2 interaction has been shown to be critical for metastasis in a breast cancer model.

  7. Decreased expression of EYA2 is associated with pancreatic adenocarcinomas.

  8. This interaction suggests that CDK6 regulates EYA2 activity, a mechanism that could be important in development and in cancer.

  9. MIR30A represses Eya2 expression by binding to the 3'-untranslated region of Eya2.The MIR30A/EYA2 axis regulates breast cancer cell proliferation and migration.

  10. Functional roles of candidate genes EYA2 (20q13) and hsa-miR-375 (2q35) were studied by siRNA-mediated knock-down and overexpression, respectively, in hrHPV-containing cell lines.

  11. Given that SIX1 and EYA are overexpressed in many tumor types, our data indicate that targeting the SIX1-EYA complex may be a potent approach to inhibit tumor progression in multiple cancer types

  12. Studies indicate that the RNA and protein levels of Eya2 is upregulated in ovarian cancer.

  13. Data implicate Eya2 as a necessary co-factor for many of the metastasis promoting functions of Six1.

  14. Expression of EYA2 in lung adenocarcinoma is augmented.

  15. Based on observation that the dachshund-binding site is located between the catalytic core & Sine Oculis binding sites within ED-Eya2, we propose that catalytic activity can be translated to SO binding through DAC, which acts as a transcriptional switch.

  16. EYA2 was found to function as transcriptional activator in ovarian cancer cells by Gal4 assay and to promote tumor growth in vivo in xenograft models.

  17. EYA2 and EYA3 displayed specificity for Tyr-142 of H2A.X

EYA2 Protein Überblick

Protein Überblick

This gene encodes a member of the eyes absent (EYA) family of proteins. The encoded protein may be post-translationally modified and may play a role in eye development. A similar protein in mice can act as a transcriptional activator. Alternative splicing results in multiple transcript variants, but the full-length natures of all of these variants have not yet been determined.

Genbezeichner und Symbole assoziert mit EYA2

  • EYA transcriptional coactivator and phosphatase 2 (EYA2)
  • EYA transcriptional coactivator and phosphatase 2 (eya2)
  • EYA transcriptional coactivator and phosphatase 2 (Eya2)
  • EAB1 Protein
  • EYA2 Protein
  • zgc:92279 Protein

Bezeichner auf Proteinebene für EYA2

eyes absent 2 , eyes absent homolog 2 , eyes absent homolog 2 (Drosophila) , Drosophila-type eyes absent 2-like protein , eyes absent 2 homolog

395745 Gallus gallus
100071250 Equus caballus
458305 Pan troglodytes
447819 Danio rerio
100037919 Xenopus (Silurana) tropicalis
100218165 Taeniopygia guttata
14049 Mus musculus
2139 Homo sapiens
156826 Rattus norvegicus
615264 Bos taurus
609926 Canis lupus familiaris
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