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DLG5 encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily.
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both polymorphisms of DLG5 are correlated with inflammatory bowel disease susceptibility in an ethnic-specific manner.
Low expression of DLG5 is associated with Crohn's disease.
Data found that Dlg5 expression was significantly lower in human hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) tissues and indicate that Dlg5 acts as a novel regulator of invadopodium-associated invasion via Girdin (zeige CCDC88A Antikörper) and by interfering with the interaction between Girdin (zeige CCDC88A Antikörper) and Tks5 (zeige SH3PXD2A Antikörper), which might be important for Tks5 (zeige SH3PXD2A Antikörper) phosphorylation in HCC (zeige FAM126A Antikörper) cells.
DLG5 inhibits the association between MST1 (zeige MST1 Antikörper)/2 and large tumor suppressor (zeige LATS1 Antikörper) homologs 1/2 (LATS1 (zeige LATS1 Antikörper)/2), uses its scaffolding function to link MST1 (zeige MST1 Antikörper)/2 with MARK3 (zeige MARK3 Antikörper), and inhibits MST1 (zeige MST1 Antikörper)/2 kinase activity
study has identified several new proteins like RHOC (zeige RHOC Antikörper), DLG5, UGDH (zeige UGDH Antikörper), TMOD3 (zeige TMOD3 Antikörper) in addition to known chemoresistance associated proteins in non-small cell lung carcinoma.
These data suggest that inhibition of Dlg5 by DNA hypermethylation contributes to provoke invasive phenotypes in bladder tumor.
Findings demonstrate that Dlg5 interacts with and inhibits the activity of Girdin (zeige CCDC88A Antikörper), thereby suppressing the migration of prostate cancer cells.
DLG5 plays a role in cell migration, cell adhesion, precursor cell division, cell proliferation, epithelial cell polarity maintenance, and transmission of extracellular signals to the membrane and cytoskeleton.
Overexpression of Dlg5 enhances the degradation of TGFBRI.
Polymorphisms in the DLG5 gene were found to be associated with Crohn's disease patients in Malaysia.
Dlg5 is required for Hh-induced enrichment of Kif7 (zeige KIF7 Antikörper) and Gli2 (zeige GLI2 Antikörper) at the tip of the cilium but is dispensable for Gpr161 (zeige GPR161 Antikörper) exit from the cilium and the consequent suppression of Gli3 (zeige GLI3 Antikörper) processing into its repressor form
DLG5 is a MAGUK protein that regulates spine formation, synaptogenesis, and synaptic transmission in cortical neurons.
Dlg5 maintains apical aPKC and regulates progenitor differentiation during lung morphogenesis.
Data report that Discs large (zeige DLG4 Antikörper) 5 (Dlg5), a member of the MAGUK family, is an interactor of CitK required for CitK polarization.
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.
discs, large homolog 5 (Drosophila)
, discs large homolog 5
, discs large protein
, discs, large homolog 5
, disks large homolog 5
, discs large protein LP-DLG
, discs large protein P-dlg
, large type of P-DLG
, placenta and prostate DLG