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The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females.
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Human Polyclonal DAZL Primary Antibody für IHC (p), IHC - ABIN250853
Hermann, Sukhwani, Lin, Sheng, Tomko, Rodriguez, Shuttleworth, McFarland, Hobbs, Pandolfi, Schatten, Orwig: Characterization, cryopreservation, and ablation of spermatogonial stem cells in adult rhesus macaques. in Stem cells (Dayton, Ohio) 2007
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Cynomolgus Monoclonal DAZL Primary Antibody für IF, IHC (p) - ABIN2473235
Fabre, Bureau, Pouliquen, Lorans: Binding sites for human interleukin 1 alpha, gamma interferon and tumor necrosis factor on cultured fibroblasts of normal cornea and keratoconus. in Current eye research 1991
Show all 4 Pubmed References
Human Polyclonal DAZL Primary Antibody für IF (p), IHC (p) - ABIN1385600
Zhang, Zhao, Zhang, Hao, Yu, Min, Li, Ma, Chen, Yi, Tang, Meng, Liu, Wang, Shen, Zhang: Decrease in male mouse fertility by hydrogen sulfide and/or ammonia can Be inheritable. in Chemosphere 2018
Human Polyclonal DAZL Primary Antibody für ICC, IF - ABIN4304346
Djureinovic, Fagerberg, Hallström, Danielsson, Lindskog, Uhlén, Pontén: The human testis-specific proteome defined by transcriptomics and antibody-based profiling. in Molecular human reproduction 2014
computational analysis of free energy change due to this point mutation using GROMOS96 indicated decreased stability of the DAZL protein. The N109T variant in an infertile male population may provide a genetic marker for mutational analysis of DAZL
Data suggest that DAZL may be one such factor in human female fertility
Through the translational regulation of novel RNA targets SMC1B (zeige SMC1B Antikörper) and TEX11 (zeige TEX11 Antikörper), DAZL may have a key role in regulating chromosome cohesion and DNA recombination; two processes fundamental in determining oocyte quality and whose establishment in foetal life may support lifelong fertility.
hypermethylation of DAZL and BOULE (zeige BOLL Antikörper) promoters in human sperm is associated with human infertility
data can be used to further elucidate the role of NANOS3 (zeige NANOS3 Antikörper) and DAZL in germ cell development both in vitro and in vivo
DAZL was not expressed either in normal cultures or lesions from cervixes with papillomavirus infections and cervical intraepithelial neoplasia.
analysis demonstrated that SNP260 of DAZL did not contribute to oligo/azoospermia while SNP386 was correlated to male infertility
Neither the A260G nor the A386G polymorphism of DAZL appeared to be involved in male infertility.
demonstrate that Boll (zeige BOLL Antikörper) is also transiently expressed during oogenesis in the fetal mouse ovary, but is simultaneously co-expressed within the same germ cells as Dazl
Abnormal DNA methylation (zeige HELLS Antikörper) of the DAZL promoter might represent an epigenetic marker of male infertility.
Cortical depth and differential transport of vegetally localized dorsal and germ line determinants, Wnt8a (zeige WNT8A Antikörper), grip2a, and Dazl, in the zebrafish embryo have been presented.
that DAZL specifically binds the HuB 3'UTR (zeige UTS2R Antikörper) and protects the message from degradation and/or enhances HuB translation, leading to the germ cell specific expression of HuB protein.
DAZL relieves miRNA-mediated repression of germline mRNAs by controlling poly(A) tail length in zebrafish
Data show that DAZ-like protein directly promotes the translation of the target mRNAs in vertebrates.
analysis of genomic structure and transcript variants of the bovine DAZL gene
The dynamic intracellular localization suggests that Dazl is a multifunctional protein regulating RNA metabolism required for Xenopus germline development
Daz- and pumilio-like genes are asymmetrically localized in Pelophylax (Rana) oocytes and are expressed during early spermatogenesis.
Dazl has the ability to stimulate translation and function at the level of translation initiation.
The 3'-UTR (zeige UTS2R Antikörper)-dependent suppression of DAZL in mouse follicular oocytes is required for the progression of normal pre-implantation development.
Down-regulated expression of Sox9 (zeige SOX9 Antikörper) and Dazl may play important roles in MBP (zeige MBP Antikörper)-induced testis injury.
DAZL and CPEB1 (zeige CPEB1 Antikörper) regulate mRNA translation during oocyte maturation.
findings demonstrate that DAZL associates with mRNA of Tet1 (zeige TET1 Antikörper), a catalyst of 5-hydroxylation of methyl-cytosine, and enhances Tet1 (zeige TET1 Antikörper) mRNA translation; DAZL enhances TET1 (zeige TET1 Antikörper)-mediated cytosine hydroxymethylation in embryonic stem cells that are actively reprogramming to a pluripotent ground state
Both yeast and mouse contain an RNA-binding protein, Rim4 (zeige RIMS4 Antikörper) and DAZL, respectively, that functions in translation and forms SDS (zeige SDS Antikörper)-resistant aggregates during gametogenesis.
Our findings strengthen the importance of RA and Dazl in the meiotic transition, provide important details about the Stra8 (zeige STRA8 Antikörper) pathway, and open avenues to investigate early meiosis through analysis of Rec8 (zeige REC8 Antikörper) induction and function
Data indicate that the germ cell-specific RNA binding protein DAZL limits both pluripotency and somatic differentiation in nascent primordial germ cells (PGCs).
Studies indicate that in Dazl-Knockout mice, cord/tubule-like structures, OSE invaginations and clusters of steroidogenic cells became increasingly prominent with age, but these abnormal structures remained benign.
alternative splicing of exon8 of mDazl leads to the generation of the novel splice variant, Dazl-Delta8.
cloning & characterization of the Deleted in AZoospermia Like (pDAZL) gene; pDAZL gene might be a good candidate gene of litter size trait & provides some marker information for marker-assisted selection.
DNA methylation (zeige HELLS Antikörper) may suppress DAZL expression in somatic cells by interfering with Sp1 (zeige SP1 Antikörper) binding.
The porcine DAZL coding sequence is highly homologous to those reported for the human and mouse cDNAs, and DAZL expression increases during oocyte maturation.
MK is able to maintain a proliferative PGC (zeige PGC Antikörper) phenotype mediated by the suppression of DAZL in early germ cells
DAZL enhances in vitro derived porcine germ cell formation and meiosis.
DAZL c.570+385 A>G and DAZL c.735+150 C>A locus were the potential molecular markers for improving the sperm quality traits in pigs.
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene.
, DAZ-like autosomal
, deleted in azoospermia-like 1
, germline specific RNA binding protein
, spermatogenesis gene on the Y-like autosomal
, deleted in azoospermia-like
, DAZ-like protein
, deleted in azoospermia-like protein
, deleted in azoospermia protein 3
, DAZ-like protein A
, DAZ-like protein B
, Deleted in azoospermia-like-B
, deleted in azoospermia-like-A
, Deleted in azoospermia-like 1