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DEDD encodes a protein that contains a death effector domain (DED). Zusätzlich bieten wir Ihnen DEDD Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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DEDD protein role in cell proliferation and migration of bladder cancer
Via direct interaction with the class III PI-3 (zeige PI3 Antikörper)-kinase (PI3KC3)/Beclin1 (zeige BECN1 Antikörper), DEDD activated autophagy and induced the degradation of Snail (zeige SNAI1 Antikörper) and Twist, two master regulators of EMT (zeige ITK Antikörper)
FAS (zeige FAS Antikörper)-associated death domain (FADD (zeige FADD Antikörper))-DED (zeige AATF Antikörper)-induced reactive oxygen species (ROS (zeige ROS1 Antikörper)) generation is triggered by membrane localization of FADD (zeige FADD Antikörper)-DED (zeige AATF Antikörper), which shifts the cells into a state that stimulates and fuels ROS (zeige ROS1 Antikörper) and ultimately results in cell death.
DEDD forms nuclear complexes with the TFIIIC102 (zeige GTF3C3 Antikörper) subunit of human transcription factor IIIC
DEDD and DEDD2 (zeige DEDD2 Antikörper) may be important mediators for death receptors and that they may target caspases to the nucleus.
In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation.
DEDD plays an important role in maintenance of the Akt (zeige AKT1 Antikörper) protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues.
DEDD acts as a novel inhibitor of the mitotic Cdk1 (zeige CDK1 Antikörper)/cyclin B1 (zeige CCNB1 Antikörper) complex and is an impeder of cell mitosis, and its absence critically influences cell and body size via modulation of rRNA synthesis
The death effector domain-containing DEDD supports S6K1 (zeige RPS6KB1 Antikörper) activity via preventing Cdk1 (zeige CDK1 Antikörper)-dependent inhibitory phosphorylation.
This gene encodes a protein that contains a death effector domain (DED). DED is a protein-protein interaction domain shared by adaptors, regulators and executors of the programmed cell death pathway. Overexpression of this gene was shown to induce weak apoptosis. Upon stimulation, this protein was found to translocate from cytoplasm to nucleus and colocalize with UBTF, a basal factor required for RNA polymerase I transcription, in the nucleolus. At least three transcript variants encoding the same protein have been found for this gene.
DEDPro1 , FLDED-1 , death effector domain-containing protein , death effector domain-containing testicular molecule , tumor necrosis factor (ligand) superfamily, member 19