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In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. Zusätzlich bieten wir Ihnen DAZAP1 Proteine (6) und DAZAP1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal DAZAP1 Primary Antibody für IHC, WB - ABIN2776659
Goina, Skoko, Pagani: Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. in Molecular and cellular biology 2008
Show all 3 Pubmed References
Human Polyclonal DAZAP1 Primary Antibody für ICC, IF - ABIN4304345
Sutherland, Sobinoff, Fraser, Redgrove, Siddall, Koopman, Hime, McLaughlin: RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis. in Journal of cellular physiology 1970
The splicing activator DAZAP1 integrates splicing control into MEK (zeige MAP2K1 Antikörper)/Erk (zeige EPHB2 Antikörper)-regulated cell proliferation and migration.
this study reports the mapping of a 42-amino acid segment (N42) at the N-terminus of DAZAP1 that is both necessary and sufficient for its transcription-dependent nuclear localization.
Data show that hnRNPA1 (zeige HNRNPA1 Antikörper)/A2, HuR (zeige ELAVL1 Antikörper) and DAZAP1 splicing factors and DHX36 (zeige DHX36 Antikörper) RNA helicase (zeige DDX46 Antikörper) bind to the ISE, with hnRNPA1 (zeige HNRNPA1 Antikörper) acting negatively and DAZAP1 positively on splicing selection
DAZAP1 can regulate mRNA translation.
data suggest that MEF2D (zeige MEF2D Antikörper)/DAZAP1 and/or DAZAP1/MEF2D (zeige MEF2D Antikörper) contribute to leukemogenesis by altering signaling pathways normally regulated by wild-type MEF2D (zeige MEF2D Antikörper) and DAZAP1
This study shows expression patterns of DAZAP1 in human corpus luteum cells and demonstrates the in vivo interaction of DAZ-like protein (DAZL (zeige DAZL Antikörper)) with DAZAP1.
DAZ cannot bind simultaneously to DAZAP1 and poly(A)-binding protein (PABP), and suggest that the phosphorylation-induced dissociation of DAZ and DAZAP1 may allow the former to stimulate translation by interacting with PABP.
The binding of the splicing factors hnRNPA1/A2 and DAZAP1 is the primary determinant of T6 BRCA1 exon 18 exclusion.
The results suggest that DAZAP1 is a component of complexes that are crucial for the degradation and silencing of mRNA.
Identification of Crem (zeige CREM Antikörper), Crisp2 (zeige CRISP2 Antikörper) and Pot1a (zeige POT1 Antikörper) as the natural substrates of DAZAP1 and show that DAZAP1 promotes the inclusion of specific exons in these genes.
The translation of the two Dazap1 transcripts is differentially regulated during spermatogenesis.
Identification of RNA consensus sequences required for binding to DAZAP1.
Dynamic changes in intranuclear and subcellular localizations of DAZAP1 during spermatogenesis have been studied.
DAZAP1 is not only essential for spermatogenesis, but also required for the normal growth and development of mice.
In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.
DAZ associated protein 1
, DAZ-associated protein 1
, deleted in azoospermia-associated protein 1
, proline-rich Vg1 mRNA-binding protein