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Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. Zusätzlich bieten wir Ihnen CYBB Antikörper (133) und CYBB Kits (12) und viele weitere Produktgruppen zu diesem Protein an.
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The nox1 (zeige NOX1 Proteine), nox2/cybb expression in zebrafish during early nervous system development from 12 to 48 hours post fertilization
Data indicate that NADPH oxidase (zeige NOX1 Proteine) NOx2 inhibition attenuates endoplasmic reticulum (ER) stress and apoptosis.
The activity of Nox2 is lowered in neutrophils of untreated hypercholesterolemic patients. Finally oxysterols (25-hydroxy-cholesterol or 5alpha, 6alpha - epoxy-cholesterol) do not induce effects different from that of non-oxidized cholesterol.
indicated that miR (zeige MLXIP Proteine)-27b exerted its protective role in retinal pigment epithelium cells under PDGF (zeige PDGFA Proteine)-BB stimulation was partially through regulation of Nox2
Findings show that under elevated glucose concentration, NOX2 is activated by SMIT1 (zeige SLC5A3 Proteine) triggering ROS (zeige ROS1 Proteine) production in the heart.
Human post-mortem and animal studies have identified elevated NOX2 and NOX4 levels in the injured brain, suggesting that these two NOXs are involved in the pathogenesis of Traumatic brain injury (TBI)
To further elucidate the mAb 7D5 epitope on human gp91(phox) , chimeric DNA expressed human and mouse gp91(phox) recombinant protein were constructed. The fusion proteins were immunostained for mAb 7D5 and analyzed by FACS and western blot analysis.
Phorbol 12-myristate-13-acetate-stimulated NOX2-NIS (NOX-specific Insertion Sequence) phosphorylation by ATM (zeige ATM Proteine) kinase causes a dynamic switch that deactivates NOX2 activity. This downregulation may be defective in NOX2-NIS3 mutant because of the absence of Ser486.
This study identifies one novel mutation in the IL2RG (zeige IL2RG Proteine) gene and another, previously described mutation in the CYBB genes. It is the first report establishing a diagnosis of X-SCID (zeige PRKDC Proteine) and X-CGD using WES in Chinese patients.
In a male patient suffering from X-linked chronic granulomatous disease (CGD) we found a c.389G>T mutation in exon 5 of the CYBB gene.
The potency of RTK inhibition by BJ-1301 was lower than that of sunitinib (a multi-RTK inhibitor), but the inhibition of downstream signaling pathways (e.g., ROS (zeige ROS1 Proteine) generation) and subsequent biological changes (e.g., NOX2 induction) by BJ-1301 was superior
Translated to human pathophysiology, (zeige ALDH2 Proteine)we found increased gp91(phox) expression in endomyocardial biopsies of Alcoholic cardiomyopathy (ACM) patients. In conclusion, ACM is promoted by ACA-driven mitochondrial dysfunction and can be improved by ablation of NOX2/gp91(phox). NOX2/gp91(phox) therefore might be a potential pharmacological target to treat ACM.
Data indicate that the efficiency of NADPH oxidase (zeige NOX1 Proteine) enzymatic activity is higher at endoplasmic reticulum (ER).
A p47(phox) and Src kinase activation of peroxide production by Nox2 appears to be an important contributor to vascular contractile mechanisms mediated through activation of protein kinase C
Reducing NADPH oxidase-2 by impeding p67(phox (zeige NCF2 Proteine)) activation in infected mouse macrophages reduced viral entry and inflammation.
the study reports a novel mechanistic pathway of leptin (zeige LEP Proteine)-mediated renal inflammation that is dependent on NOX-2-miR21 axis in ectopic manifestations underlying non-alcoholic fatty liver disease-induced co-morbidities
Whereas the oxidative burst in myeloid cells is mainly catalyzed by the NOX2 isotype, in epithelial cells other isotypes of the NADPH (zeige FDXR Proteine) oxidases family are involved, especially NOX4 (zeige NOX4 Proteine)
Proximal point of bifurcation in cardiac insulin (zeige INS Proteine) signaling through the simultaneous activation of both NOX2 and NOX4 (zeige NOX4 Proteine) was identified. Each NOX isoform generates H2O2 in cardiac myocytes with distinct time courses, with H2O2 derived from NOX2 augmenting Akt (zeige AKT1 Proteine)-dependent metabolic effects of insulin (zeige INS Proteine), while H2O2 from NOX4 (zeige NOX4 Proteine) blocks beta adrenergic increases in inotropy.
AIF (zeige AIFM1 Proteine) activated AMPK (zeige PRKAA1 Proteine)-dependent Nox2 signaling pathway.
Nox2 may be a therapeutic target for AII (zeige ARG2 Proteine)-induced skeletal muscle atrophy.
These results indicated that integrin CD11b (zeige ITGAM Proteine) mediates alpha-synuclein-induced NOX2 activation through a RhoA (zeige RHOA Proteine)-dependent pathway.
These results showed that CR3 (zeige ITGAM Proteine) regulated Nox2 activation and dopaminergic neurodegeneration through a Src (zeige SRC Proteine)-Erk (zeige EPHB2 Proteine)-dependent pathway in a two pesticide-induced Parkinson's disease (PD) model, providing novel insights into the immune pathogenesis of PD.
High levels of NOX2 were found in mouse adult neurogenic brain regions. NOX2-deficient brain showed decrease in neuroprecursor cell pool and lowered expression of genes involved in neural differentiation.
Echocardiography revealed that ALDH-2 (zeige ALDH2 Proteine)(-/-)/gp91(phox-/-) mice were protected from ACA-overload-induced HF after 5 weeks of 2% EtOH-diet, demonstrating that NOX2-derived O2(*-) contributes to the development of ACM
These results suggested that resveratrol strongly enhances the RA-induced O2(-)-generating activity via up-regulation of gp91-phox gene expression in U937 cells.
sub-vasomotor concentration of ET-1 (zeige EDN1 Proteine) leads to vascular dysfunction by impairing endothelium-dependent NO-mediated dilation via p38 (zeige MAPK14 Proteine) kinase-mediated production of superoxide from NADPH oxidase (zeige NOX1 Proteine) following ETA receptor activation
Reactive oxygen species generated by NADPH oxidase (zeige NOX1 Proteine) contribute to the aberrant pulmonary arterial responses in piglets exposed to 3 days of hypoxia.
Upregulation of PPAR-gamma and NADPH oxidases are involved in restenosis.
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase\; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole.
cytochrome b-245, beta polypeptide
, NADPH oxidase 2
, cytochrome b-245, beta polypeptide (chronic granulomatous disease)
, Cytochrome b-245 heavy chain
, NADPH oxidase heavy chain subunit
, NADPH oxidase 1
, NADPH oxidase flavocytochrome b subunit
, cytochrome b-245 heavy chain
, cytochrome b(558) subunit beta
, cytochrome b558 subunit beta
, heme-binding membrane glycoprotein gp91phox
, neutrophil cytochrome b 91 kDa polypeptide
, p22 phagocyte B-cytochrome
, superoxide-generating NADPH oxidase heavy chain subunit
, endothelial type gp91-phox
, predicted NADPH oxidase-2