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The protein encoded by CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. Zusätzlich bieten wir Ihnen Cystathionine-beta-Synthase Antikörper (121) und Cystathionine-beta-Synthase Kits (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human CBS Protein expressed in Wheat germ - ABIN1348191
Austgen, Hermann, Dantzler, Rogers, Kline: Hydrogen sulfide augments synaptic neurotransmission in the nucleus of the solitary tract. in Journal of neurophysiology 2011
Show all 4 Pubmed References
Results indicate that activation of the cystathionine-beta-synthase (CBS) and its product hydrogen sulfide (zeige SQRDL Proteine) (CBS/H2S axis promotes colon carcinogenesis.
showed that N-homocysteinylation of collagen in Cbs(-/-) mice impairs its cross-linking
the findings of this study indicate that a deficiency in 3MST does not significantly affect endotoxemia, while a deficiency in CBS or CSE (zeige CTH Proteine) slightly ameliorates the outcome of LPS (zeige TLR4 Proteine)-induced endotoxemia in vivo.
These data confirm a key role for the H2S-generating enzymes Cbs and Cth (zeige CTH Proteine) in pulmonary vascular development and homeostasis and in lung alveolarization.
genetic deficiency results in reduced Tet1 (zeige TET1 Proteine) and Tet2 expression, which leads to hypermethylation of Foxp3 (zeige FOXP3 Proteine), and impairment of Treg cell differentiation and immune homeostasis.
Elevated homocytsteine levels in the CBS-/+ mouse skeletal muscles caused diminished anti-oxidant capacity and contributed to enhanced total protein as well as PGC-1alpha specific nitrotyrosylation after ischemia.
CBS disruption causes embryo retention and developmental delay in the mouse oviduct.
CBS is present in adrenocortical cells and accounts for H2S generation in adrenal glands. CBS is critical for maintenance of mitochondrial function and glucocorticoid production in adrenal cortex.
Elevating endogenous H2S via CBS over-expression in immortalized microglia not only reduced the expression of pro-inflammatory M1 genes, but also enhanced the anti-inflammatory M2 marker IL-10 (zeige IL10 Proteine) production.
Cbs protein expression is upregulated in brain cortex following traumatic brain injury.
c.797 G>A (p.R266K) cystathionine beta-synthase mutation has a role in causing homocystinuria by affecting protein stability
The current study observed significant differences in the frequency of the CBS 844ins68 allele across populations. There is a significant association between CBS c.844ins68 polymorphism and cleft lip and palate in the Indian population.
Cystathionine beta-synthase and PGRMC1 (zeige PGRMC1 Proteine) function as carbon monoxide sensors in health and disease. (Review)
These findings may contribute to highlight that the MTHFR (zeige MTHFR Proteine) and CBS polymorphisms involvement in sickle cell anemia (SCA)pathophysiology is likely to be far more complex than it was explored to date
Uterine artery hydrogen sulfide (zeige SQRDL Proteine) production is augmented with endothelium and smooth muscle CBS upregulation, contributing to uterine artery vasodilation in the estrogen-dominant physiological states in the proliferative phase of the menstrual cycle and pregnancy.
Common polymorphisms in MTHFR (zeige MTHFR Proteine), methionine synthase (zeige MTR Proteine) and cystathione beta lyase genes have no role in premature acute myocardial infarction in Pakistani population.
Inducible expression of CBS and CSE was found to be associated with a mineralizing phenotype in mesenchymal stem cells transitioning to mineralizing osteoblasts.
SNPs in CBS were not related to relevant changes in homocysteine levels in coronary artery disease patients or controls.
The CBS rs2124459 was associated with a reduced risk of cleft palate in both French and Belgian populations. These results highlight the prominent involvement of the vitamin B6-dependent transsulfuration pathway of homocysteine in orofacial cleft risk and the interest for evaluating vitamin B6 status in further population studies.
These findings indicate that greater synthesis of phosphatidylcholine (zeige SGMS1 Proteine) and antioxidants contribute to the better performance and immuno-metabolic status in methionine-supplemented cows.
The protein encoded by this gene acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. The encoded protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria. Multiple alternatively spliced transcript variants have been found for this gene.
, cystathionine beta-synthase
, cystathionine beta-synthase CBS
, hemoprotein H-450
, serine sulfhydrase
, methylcysteine synthase