Cyclin-Dependent Kinase 2 Associated Protein 1 Proteine (CDK2AP1)

The protein encoded by CDK2AP1 is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. Zusätzlich bieten wir Ihnen Cyclin-Dependent Kinase 2 Associated Protein 1 Antikörper (65) und Cyclin-Dependent Kinase 2 Associated Protein 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CDK2AP1 13445 O35207
CDK2AP1 8099 O14519
Ratte CDK2AP1 CDK2AP1 360804  
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Top Cyclin-Dependent Kinase 2 Associated Protein 1 Proteine auf antikoerper-online.de

Showing 10 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
$5,370.21
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 30 bis 35 Tage
$5,370.21
Details
Escherichia coli (E. coli) Human His tag 100 μg 15 bis 19 Tage
$519.23
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human CDK2AP1 Protein. 100 μg 11 bis 18 Tage
$469.05
Details
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
$414.29
Details
Human Cells Human His tag   10 μg 15 bis 16 Tage
$300.00
Details
Hefe Syrischer Goldhamster His tag   1 mg 60 bis 71 Tage
$2,218.33
Details
Escherichia coli (E. coli) Human His tag   1 mg 2 bis 3 Tage
$3,055.38
Details
Human Unkonjugiert   1 mg 6 Days
$3,435.54
Details

CDK2AP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, ,

Weitere Proteine zu Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) Interaktionspartnern

Mouse (Murine) Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) Interaktionspartner

  1. Cdk2ap1 expression is primarily regulated by progesterone and the progesterone receptor in uterus and is mainly localized to proliferating tissues.

  2. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex.

  3. (CDK2-AP1) is a potential gene therapeutic agent for oral/head and neck cancer in conjunction with DNA-damaging agents such as cisplatin.

  4. p12CDK2-AP1 forms nuclear homodimers in contact inhibited normal diploid cells and dimerization of p12 is a necessary process for the growth inhibition effect by p12

  5. Results suggest that overexpression of CDK2-associating protein 1 (p12CDK2AP1) leads to testicular and ovarian abnormalities, a phenotype closely related to that of cdk2-/- mice.

  6. Cdk2ap1, a negative regulator of Cdk2 function and cell cycle, promotes Oct4 promoter methylation during murine embryonic stem cell differentiation to down-regulate Oct4 expression.

  7. Cdk2ap1 plays an essential role in the early stage of embryogenesis and has a potential role during craniofacial morphogenesis.

  8. CDK2AP1-mediated differentiation of murine embryonic stem cell was elicited through the regulation of pRb.

Human Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) Interaktionspartner

  1. A compelling relationship exists between high CDK2AP1 mRNA expression and lower TNM classification of breast cancer, which is consistent with CDK2AP1 having a tumour-suppressive function.

  2. Knockdown of CDK2AP1 in hESCs results in increased p53 and enhances differentiation and favors it over a self-renewal fate.

  3. DOC1 re-expression in oral cancer cells causes a reversal of EMT. DOC1 promotes NURD binding to a subset of target loci.

  4. The simultaneous overexpression of p12CDK2-AP1 and CD82 significantly suppressed the in vivo tumor growth.

  5. knockdown of CDK2AP1 in primary human fibroblasts reduced proliferation and induced premature senescence, with the observed phenotype being p53 dependent

  6. In summary, p12CDK2AP1 expression in myxofibrosarcoma cells induces G0/G1 arrest and mitochondria dependent proapoptotic activity and down-regulation of p12CDK2AP1 by shRNAi results in up-regulation of the CDK2 transcript and protein.

  7. Study reports that knockdown of CDK2AP1 by RNAi in glioma cells could effectively inhibit cell proliferation by inducing cell cycle arrest and apoptosis

  8. CDK2AP1 plays an important role in modulating the growth and tumorigenesis of lung cancer cells.

  9. Low CDK2AP1 expression is common and associated with adverse prognosis in nasopharyngeal carcinoma.

  10. Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region

  11. exerts its effect on stem cell maintenance/differentiation through epigenetic regulation [review]

  12. In comparison with the healthy gingiva, the expression of Doc-1 was decreased, whereas the expression of S100A7 was upregulated in all oral lesions.

  13. P12(CDK2AP1) is downregulated by miR-21

  14. Missing down-regulation of the tumor-suppressor gene DOC-1, might exert protective effects and counteract malignant transformation of benign, proliferating lesions of the oral cavity.

  15. Data support the role of cdk2ap1 as a tumor suppressor gene that can regulate squamous cell carcinoma growth in a cell autonomous manner through decreases in invasiveness and a non-cell autonomous manner through decreases in angiogenesis phenotypes.

  16. The combination of an increased expression of the antimicrobial peptide DEFA-4, the oncogene S100-A7, epidermal growth factor, and tenascin-c, and a decreased Doc-1 expression in oral leukoplakia might characterize its potency of malignant transformation.

  17. Results indicate that DOC-1 is a bona fide subunit of the Mi-2/NuRD chromatin remodeling complex.

  18. CDK2AP1 is a novel multiple sclerosis susceptibility loci, and it's risk allele correlates with diminished RNA expression of the cell cycle regulator CDK2AP1

  19. Data show low or moderate methylation was found in seven selected genes BAD, BBC3, CAV1, CDK2AP1, NPM1, PRKCDBP and THEM4.

  20. DOC1 has a differential expression in microsatellite-unstable human colorectal neoplasms.

Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1) Protein Überblick

Protein Überblick

The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit CDK2AP1

  • cyclin-dependent kinase 2 associated protein 1 S homeolog (cdk2ap1.S)
  • cyclin dependent kinase 2 associated protein 1 (CDK2AP1)
  • cyclin dependent kinase 2 associated protein 1 pseudogene (LOC475806)
  • cyclin-dependent kinase 2 associated protein 1 (cdk2ap1)
  • CDK2 (cyclin-dependent kinase 2)-associated protein 1 (Cdk2ap1)
  • cyclin-dependent kinase 2 associated protein 1 (Cdk2ap1)
  • cyclin dependent kinase 2 associated protein 1 (Cdk2ap1)
  • Apc10 Protein
  • Cdkap1 Protein
  • doc-1 Protein
  • DOC1 Protein
  • DORC1 Protein
  • MGC64532 Protein
  • p12 Protein
  • p12DOC-1 Protein
  • ST19 Protein

Bezeichner auf Proteinebene für CDK2AP1

cyclin-dependent kinase 2 associated protein 1 , CDK2-associated protein 1 , CDK2 (cyclin-dependent kinase 2)-associated protein 1 , cyclin-dependent kinase 2-associated protein 1 , CDK2-associated protein1 , deleted in oral cancer 1 , putative oral cancer suppressor , Deleted in oral cancer-1

GENE ID SPEZIES
380551 Xenopus laevis
452342 Pan troglodytes
475806 Canis lupus familiaris
549484 Xenopus (Silurana) tropicalis
615387 Bos taurus
704412 Macaca mulatta
100153712 Sus scrofa
13445 Mus musculus
8099 Homo sapiens
360804 Rattus norvegicus
101825251 Mesocricetus auratus
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