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CFC1 encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development.
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Mouse (Murine) Polyclonal CFC1 Primary Antibody für ELISA, IHC - ABIN269818
Bianco, Strizzi, Ebert, Chang, Rehman, Normanno, Guedez, Salloum, Ginsburg, Sun, Khan, Hirota, Wallace-Jones, Wechselberger, Vonderhaar, Tosato, Stetler-Stevenson, Sanicola, Salomon: Role of human cripto-1 in tumor angiogenesis. in Journal of the National Cancer Institute 2005
The knockdown and overexpression of CFC1 were performed using a lentiviral system in NB cell lines. The overexpression of CFC1 increased sphere formation, cell growth, and colony formation.
Results demonstrated that over expression of Snail (zeige SNAI1 Antikörper) suppresses Cryptic expression and confirmed that Snail (zeige SNAI1 Antikörper) directly binds to Cryptic gene promoter and regulates its expression.
enhances macrophage phagocytic activity and upregulates the production of anti- and pro-inflammatory cytokines via the NF-kappaB (zeige NFKB1 Antikörper) signaling pathway
Data indicate that the duplication and deletion of CFC1 protein may play key roles in the occurrence of heterotaxy syndrome.
CFC1 may be involved in the etiology of non-syndromic congenital heart disease in a Chinese population.
CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle
results suggest that heterozygous cryptic family 1 (CFC1) mutation may represent a genetic predisposition to biliary atresia splenic malformation syndrome
Functional redundancy of the Cfc1 gene in epiblast and extraembryonic patterning during early mouse embryogenesis is reported.
Cripto (zeige TDGF1 Antikörper), which encodes a Nodal co-receptor, is a primary target of beta-catenin (zeige CTNNB1 Antikörper) signals in embryogenesis.
cells coexpressing GRP78 (zeige HSPA5 Antikörper) and Cripto (zeige TDGF1 Antikörper) grow much more rapidly in soft agar than do cells expressing either protein individually
This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development, including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
cripto, FRL-1, cryptic family 1
, cripto, FRL-1, cryptic family 1B
, cryptic protein
, fibroblast growth factor receptor ligand 1
, cryptic family protein 1
, CRIPTO-related factor 1