Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Proteine (CBFA2T3)

CBFA2T3 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Zusätzlich bieten wir Ihnen Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CBFA2T3 12398 O54972
CBFA2T3 863 O75081
Ratte CBFA2T3 CBFA2T3 361431  
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$340.00
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CBFA2T3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Interaktionspartnern

Mouse (Murine) Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Interaktionspartner

  1. Study reveals a complex pattern of gene regulation by SCL, ETO2 and RYBP. Genome-wide analyses shows locus-specific binding of ETO2 and RYBP on SCL's 778 activated and repressed genes.

  2. gene deficient mice have decreased levels of systemic monocytes and infarct-associated macrophages and display compromised tissue healing and post-MI heart failure

  3. MTG16 loss promotes radioresistance and impacts intestinal stem cell function, possibly due to shifting cellular response away from DNA damage-induced apoptosis and towards DNA repair after injury.

  4. Mtg16 promotes plasmacytoid dendritic cell differentiation and restricts classical dendritic cell development in part by repressing Id2.

  5. MTG16 is critical for colonocyte survival and regeneration in response to intestinal injury and provide evidence that this transcriptional corepressor regulates inflammatory recruitment in response to injury.

  6. Mtg16 integrates the activities of signaling pathways and nuclear factors in the establishment of T-cell fate specification.

  7. Data suggest that MTG16 interfaces with critical components of the Notch transcription complex to affect Notch-dependent lineage allocation in hematopoiesis.

  8. association with T-cell acute lymphocytic leukemia 1, ETO-2 represses gene expression in the early stages of erythroid differentiation

  9. The dynamics of ETO2 recruitment within nuclear complexes couple cell proliferation to cell differentiation and determine the onset of terminal erythroid maturation.

  10. MTG8/ETO and Mtg16 (also known as ETO2) associated with TCF4

  11. These data suggest that ETO2 directly represses inappropriate early expression of a subset of terminally expressed megakaryocyte genes by binding to GATA1 and SCL.

  12. the transcriptional corepressor Mtg16 (myeloid translocation gene on chromosome 16), which is targeted by t(16;21) in acute myeloid leukemia, is required for hematopoietic progenitor cell fate decisions and for early progenitor cell proliferation.

  13. Eto2 and Mtgr1 as authentic interaction partners of Tal1 and suggest they act as heteromeric corepressors of this bHLH transcription factor during erythroid differentiation.

Human Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Interaktionspartner

  1. The here presented transcriptomic subgroup-based approach unified the gene expression profiles of RUNX1-CBFA2T3 and RUNX1-RUNX1T1 acute myeloid leukemia.

  2. Analysis of chromatin immunoprecipitation sequencing data sets for MTGR1 and MTG16 targets indicated that MTGR1 can regulate Wnt and Notch signaling.

  3. CBFA2T3 expression is regulated by Med19 in breast cancer cells.

  4. specific interference with ETO2-GLIS2 oligomerization reverses the transcriptional activation at enhancers and promotes megakaryocytic differentiation, providing a relevant interface to target in this poor-prognosis pediatric leukemia.

  5. Clinical courses of pediatric patients with AMKL harboring the CBFA2T3-GLIS2 fusion gene are poor due to resistance to chemotherapies and SCT. New treatment strategies are necessary.

  6. ETO2 and IRF2BP2 interacting with the NCOR1/SMRT co-repressor complex, suppresses the expression of erythroid genes until erythroid differentiation.

  7. MTG16 co-repressor promotes degradation of HIF1alpha in lymphoblasts.

  8. study defined eight additional recurrently mutated genes in SMZL; these genes are CREBBP, CBFA2T3, AMOTL1, FAT4, FBXO11, PLA2G4D, TRRAP and USH2A.

  9. Findings are unprecedented and indicate that the DHH-RHEBL1 fusion transcript is a novel recurrent feature in the changing landscape of CBFA2T3-GLIS2-positive childhood AML.

  10. Expression of MTG16 reduced glycolytic metabolism while mitochondrial respiration and formation of reactive oxygen species increased.

  11. presence of MTG16 in this complex, and its contributions to transcriptional repression both required Kaiso binding to its binding site on DNA, establishing MTG16-Kaiso binding as functionally relevant in Kaiso-dependent transcriptional repression

  12. Data indicate taht ETO2/CBFA2T3 regulates GATA-1 target genes critical for erythroid differentiation, and the decrease of ETO2 levels during erythroid differentiation would contribute to the activation of these targets.

  13. Identification of a cryptic chromosome 16 inversion (inv(16)(p13.3q24.3)) in 27% of pediatric acute megakaryoblastic leukemia cases, which encodes a CBFA2T3-GLIS2 fusion protein.

  14. An evolutionary conserved GATA binding site is critical in transcriptional regulation of the MTG16 promoter.

  15. Our data indicate that the CBFA2T3/ACSF3 locus is a novel recurrent oncogenic target of immunoglobulin heavy chain translocations, which might contribute to the pathogenesis of pediatric GC-derived B-cell lymphoma.

  16. Alternative NLI complexes mediate gamma-globin transcription or silencing through long-range locus control region interactions involving an intergenic site of noncoding RNA transcription and that ETO2 is critical to this process.

  17. Study provides the first evidence that MTG16b is a dual AKAP capable of binding plexins.

  18. Data show that ZNF651 is a ZNF652 paralogue that shares a common DNA binding sequence with ZNF652 and represses target gene expression through the formation of a CBFA2T3-ZNF651 corepressor complex.

  19. In the first pediatric leukemia case in whom AML1-MTG16 was identified, the breakpoint of MTG16 was determined, and suggested as a possible characteristic of secondary leukemia.

  20. CBFA2T3 (MTG16) is a putative breast tumor suppressor gene from the breast cancer loss of heterozygosity region at 16q24.3.

Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 3 (CBFA2T3) Protein Überblick

Protein Überblick

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(16\;21)(q24\;q22) translocation is one of the less common karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. This gene is also a putative breast tumor suppressor. Alternative splicing results in transcript variants.

Genbezeichner und Symbole assoziert mit CBFA2T3

  • core-binding factor, runt domain, alpha subunit 2, translocated to, 3 (human) (Cbfa2t3)
  • CBFA2/RUNX1 translocation partner 3 (CBFA2T3)
  • CBFA2/RUNX1 translocation partner 3 (Cbfa2t3)
  • A630044F12Rik Protein
  • AI465270 Protein
  • AW229127 Protein
  • Cbfa2t3h Protein
  • ETO-2 Protein
  • ETO2 Protein
  • MTG16 Protein
  • MTG16a Protein
  • MTG16b Protein
  • MTGR2 Protein
  • ZMYND4 Protein

Bezeichner auf Proteinebene für CBFA2T3

ETO/MTG8-related protein ETO-2 , MTG8-related protein 2 , core-binding factor, runt domain, alpha subunit 2; translocated to, 3 homolog; CBFA2T3 identified gene homolog , eight twenty one protein 2 , myeloid translocation gene-related protein 2 , protein CBFA2T3 , protein ETO-2 , MTG8-related gene 2 , myeloid translocation gene 8 and 16b , myeloid translocation gene on chromosome 16 protein , zinc finger MYND domain-containing protein 4 , translocated to, 3

GENE ID SPEZIES
12398 Mus musculus
415846 Gallus gallus
863 Homo sapiens
361431 Rattus norvegicus
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