Coiled-Coil Domain Containing 99 Proteine (CCDC99)

Required for the localization of dynein and dynactin to the mitotic kintochore. Zusätzlich bieten wir Ihnen Coiled-Coil Domain Containing 99 Antikörper (61) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CCDC99 54908 Q96EA4
CCDC99 70385 Q923A2
CCDC99 303037 Q3KR99
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Showing 5 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,719.83
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CCDC99 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Coiled-Coil Domain Containing 99 (CCDC99) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Coiled-Coil Domain Containing 99 (CCDC99) Interaktionspartner

  1. Spindly is a novel regulator of mitotic dynein, functioning specifically to target dynein to kinetochores.

Arabidopsis thaliana Coiled-Coil Domain Containing 99 (CCDC99) Interaktionspartner

  1. posttranslational modification of TCP14/15 by SPY inhibits their proteolysis.

  2. The study revealed that SPY-dependent protein O-fucosylation plays a key role in regulating plant development.

  3. SPINDLY regulates cortex proliferation by maintaining cellular redox homeostasis

  4. SPY plays a negative role in plant abiotic stress tolerance, probably by integrating environmental stress signals via gibberellic acid and Cytokinins cross talk.

  5. Data suggest that responses of leaves and flowers to CK are mediated by SPY-dependent TCP14 and TCP15 activities.

  6. spy-4 partially suppressed the reduced abundance of CONSTANS and FLOWERING LOCUS T RNA and the late flowering of gigantea mutant plants

  7. Our results demonstrate that SPY acts as both a repressor of GA responses and a positive regulator of cytokinin signaling. Hence, SPY may play a central role in the regulation of GA/cytokinin cross talk during plant development.

  8. SPY acts in the cytosol to suppress gibberellin responses and to promote cytokinin signaling.

Human Coiled-Coil Domain Containing 99 (CCDC99) Interaktionspartner

  1. Farnesylation of Spindly is essential for its localization, & thus for proper localization of dynein & dynactin (zeige DCTN1 Proteine), to prometaphase kinetochores. Both Spindly and CENP-E (zeige CENPE Proteine) farnesylation are required for efficient chromosome congression

  2. hSpindly is farnesylated in vivo and farnesylation is essential for its interaction with the RZZ complex and hence Kinetochore localization.

  3. Spindly is not only required for kinetochore localization of dynein but is a functional component of a mechanism that couples dynein-dependent poleward movement of chromosomes to their efficient attachment to microtubules.

  4. dynein-mediated removal of Spindly from microtubule-attached kinetochores, rather than poleward transport per se, is the critical reaction in checkpoint silencing

  5. [hSpindly] Localization of human Spindly (hSpindly) to kinetochores is controlled by the Rod/Zw10 (zeige ZW10 Proteine)/Zwilch (zeige ZWILCH Proteine) (RZZ) complex and Aurora B (zeige AURKB Proteine).

Mouse (Murine) Coiled-Coil Domain Containing 99 (CCDC99) Interaktionspartner

  1. Overexpression of mSpindly failed to enhance inactivation of SAC (zeige ADCY10 Proteine) and acceleration of the meiotic process.

Coiled-Coil Domain Containing 99 (CCDC99) Protein Überblick

Protein Überblick

Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex (By similarity).

Genbezeichner und Symbole assoziert mit CCDC99

  • CG15415 gene product from transcript CG15415-RB (Spindly)
  • Tetratricopeptide repeat (TPR)-like superfamily protein (SPY)
  • spindle apparatus coiled-coil protein 1 (spdl1)
  • spindle apparatus coiled-coil protein 1 (SPDL1)
  • spindle apparatus coiled-coil protein 1 (Spdl1)
  • spindle apparatus coiled-coil protein 1 L homeolog (spdl1.L)
  • 1700018I02Rik Protein
  • 2600001J17Rik Protein
  • 2810049B11Rik Protein
  • AA409762 Protein
  • Ccdc99 Protein
  • ccdc99-a Protein
  • ccdc99-b Protein
  • CG15415 Protein
  • Dmel\\CG15415 Protein
  • RGD1306908 Protein
  • spdl1 Protein
  • spdl1-a Protein
  • SPINDLY Protein

Bezeichner auf Proteinebene für CCDC99

spindly , CG15415-PB , Spindly-PB , coiled-coil domain containing 99 , coiled-coil domain-containing protein 99 , protein Spindly , spindle apparatus coiled-coil domain-containing protein 1 , arsenite-related gene 1 protein , hSpindly , rhabdomyosarcoma antigen MU-RMS-40.4A , rrhabdomyosarcoma antigen protein MU-RMS-40.4A , spindly homolog , Coiled-coil domain-containing protein 99-A , protein Spindly-A , spindle apparatus coiled-coil domain-containing protein 1-A

GENE ID SPEZIES
33578 Drosophila melanogaster
820327 Arabidopsis thaliana
100170491 Xenopus (Silurana) tropicalis
515158 Bos taurus
54908 Homo sapiens
70385 Mus musculus
303037 Rattus norvegicus
734358 Xenopus laevis
568360 Danio rerio
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