Coagulation Factor XI (F11) ELISA Kits

F11 encodes coagulation factor XI of the blood coagulation cascade. Zusätzlich bieten wir Ihnen Factor XI Antikörper (143) und Factor XI Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
F11 2160 P03951
F11 109821 Q91Y47
F11 290757  
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Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 19.5 pg/mL 78.1-5000 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Ratte 0.21 ng/mL 0.47 ng/mL - 30 ng/mL 96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
Affe 0.469 ng/mL 0.781-50 ng/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
  96 Tests Anmelden zum Anzeigen 2 bis 3 Tage
Meerschweinchen 0.1 ng/mL 2.5-50 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Kaninchen 0.1 ng/mL 2.5-50 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Huhn 0.188 ng/mL 0.313-20 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
Hund 0.1 ng/mL 2.5-50 ng/mL   96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage

Am meisten referenzierte Factor XI ELISA Kits

  1. Human Factor XI ELISA Kit für Sandwich ELISA - ABIN2010750 : Lewis, Suchindran, Beckman, Hooper, Grant, Heit, Manco-Johnson, Moll, Philipp, Kenney, De Staercke, Pyle, Chi, Ortel: Whole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism. in Thrombosis research 2015 (PubMed)

Weitere ELISA Kits für Factor XI Interaktionspartner

Human Coagulation Factor XI (F11) Interaktionspartner

  1. Direct DNA sequencing analysis of the F11 genes revealed that all of the 14 patients had a F11 gene mutation. Eight different mutations were identified in the apple 1, apple 2 or serine protease domains, except one which was a splice site mutation. Six of the mutations were recurrent.

  2. The aim of the current study was to analyze, for the first time in the Portuguese population, five well known and replicated venous thromboembolism - associated single nucleotide polymorphisms in genes ABO (rs2519093 and rs8176719), F11 (rs2036914 and rs2289252) and FGG (rs2066865), and to determine its possible association with risk for venous thromboembolism.

  3. Data indicate four new factor XI (FXI) gene defects potentially causing a functional deficiency and the duplication of 1653 bp involving exons 8 and 9.

  4. In this prospective cohort of elderly adults, there was no statistically significant association of higher FXI levels with incident coronary heart disease and stroke.

  5. Higher FIX antigen levels are associated with incident coronary heart disease in blacks but not in whites; the association of FXI levels with ischemic stroke is slightly attenuated after adjusting for stroke risk factors.

  6. High molecular weight kininogen has an inhibitory effect on nucleic acid-supported fXI activation and may function as a negative regulator of fXI activation.

  7. FXI has a role in promoting a vascular coagulation-inflammatory circuit in arterial hypertension

  8. thrombin activatable fibrinolysis inhibitor pathway impairment, largely caused by a hitherto unknown TAFIa resistance, appears to be one main cause of decreased fibrinolytic resistance in FXI deficiency

  9. factor XI has a role in procoagulant microparticle-promoted coagulation in human endotoxemia

  10. Three loci showed robust, replicating association with circulating FXI levels: KNG1 (rs710446, P-value = 2.07 x 10-302), F11 (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin time

  11. The rs710446 and five low-frequency variant sets in KNG1 with FXI level variation of Factor XI were significant after multiple testing correction and permutation.

  12. Exploring the global landscape of genetic variation in coagulation factor XI deficiency

  13. Structures of FXI in complex with the laminin-derived peptide EFPDFP and a DFP peptide from the random screen demonstrated binding in the same pocket, although in a slightly different conformation, thus revealing some flexibility in the molecular interactions of the FXI apple 2 domain.

  14. inhibition of FXI and FXII distinctly alter the biophysical properties of fibrin.

  15. Acute Coronary Syndrome patients had an enhanced prothrombotic profile, demonstrated by an increased thrombin generation potential, factor XIa and D-dimer levels.

  16. Data show that among the studied polymorphisms, only coagulation factor XI (F11) single nucleotide polymorphism rs2289252 was significantly associated with venous thrombosis (VT) and the F11 rs2289252-A allele was associated with a 1.6-fold increased risk of VT

  17. Thus in conclusion, the bleeding manifestations in FXI deficiency are varied and unpredictable; neither correlates with FXI levels nor with the mutations. Comprehensive analysis of all the factors including both plasma and platelet FXI, global hemostatic factors like thrombin generation potential may indicate a potential laboratory indicator for FXI deficiency related bleeding manifestations.

  18. Fasudil reduced LPS-mediated TF and PAI-1 expression and activity in PBMCs. These effects may partially be relevant to the clinical benefits of fasudil in the treatment of CAPD patients.

  19. rs2289252 and rs2036914 polymorphisms have important role in development of venous thromboembolism in the white race

  20. High activity of factor XI indicates a risk of occurrence of deep vein thrombosis in post-trauma patients with fractures. F11 rs2089252 and rs2036914 (single nucleotide polymorphisms) are associated with activity of factors XI in such patients despite prophylaxis.

Cow (Bovine) Coagulation Factor XI (F11) Interaktionspartner

  1. Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.

  2. DNA was extracted and amplified from the bovine mummified fetuses, and the samples were successfully tested for Factor XI gene deficiency in the mummies.

  3. Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.

  4. The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene

Mouse (Murine) Coagulation Factor XI (F11) Interaktionspartner

  1. FXI(-/-) mice have a mild hemostatic defect after injury to the saphenous vein but not after transection of the tail or vessels in the abdominal wall.

  2. FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa.

  3. FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII.

  4. Thrombin-independent contribution of tissue factor to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.

  5. FXI deprivation was shown to slow down atherogenesis in Apoe knockout mice.

  6. anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin are also required for expression of polyP cofactor activity during FXI activation

  7. Factor XI antisense oligonucleotides safely prevent thrombus formation on acutely ruptured atherosclerotic plaques in mice.

  8. Data conclude that within the mouse F11, Klkb1, Cyp4v3 gene cluster, F11 and Cyp4v3 frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements.

  9. Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis.

  10. Protective roles for fibrin, tissue factor, plasminogen activator inhibitor-1, and thrombin activatable fibrinolysis inhibitor, but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.

  11. fXI and fXII contribute to thrombus formation even when factor VIIa/tissue factor initiates thrombosis.

  12. Gene targeting of tissue factor, factor X, and factor VII in mice: their involvement in embryonic development

  13. FXI is essential for thrombus formation following FeCl3-induced injury of the carotid artery in the mouse.

  14. FIX and FXI deficiency cause similar effects in the carotid artery injury model

  15. fXI may have functions in regulation of inflammation or tissue repair distinct from its role in coagulation

  16. apolipoprotein E receptor 2 (ApoER2, LRP8), a member of the LDL receptor family, is a platelet receptor for FXI.

Factor XI (F11) Antigen-Profil

Beschreibung des Gens

This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Genbezeichner und Symbole assoziert mit Coagulation Factor XI (F11) ELISA Kits

  • coagulation factor XI (F11) Antikörper
  • coagulation factor XI (CpipJ_CPIJ000593) Antikörper
  • coagulation factor XI (CpipJ_CPIJ001060) Antikörper
  • coagulation factor XI (CpipJ_CPIJ002752) Antikörper
  • coagulation factor XI (CpipJ_CPIJ003631) Antikörper
  • coagulation factor XI (CpipJ_CPIJ004041) Antikörper
  • coagulation factor XI (CpipJ_CPIJ004093) Antikörper
  • 1600027G01Rik Antikörper
  • AI503996 Antikörper
  • Cf11 Antikörper
  • FXI Antikörper
  • LRRGT00086 Antikörper

Bezeichner auf Proteinebene für Coagulation Factor XI (F11) ELISA Kits

PTA , plasma thromboplastin antecedent , coagulation factor XI (plasma thromboplastin antecedent) , factor XI , platelet coagulation factor XI , blood coagulation factor XI , coagulation factor XI , coagulation factor XI-like

2160 Homo sapiens
100009596 Oryctolagus cuniculus
422723 Gallus gallus
461643 Pan troglodytes
407998 Bos taurus
109821 Mus musculus
290757 Rattus norvegicus
475623 Canis lupus familiaris
6031603 Culex quinquefasciatus
6032063 Culex quinquefasciatus
6033946 Culex quinquefasciatus
6035180 Culex quinquefasciatus
6035438 Culex quinquefasciatus
6035567 Culex quinquefasciatus
100443368 Pongo abelii
100468102 Ailuropoda melanoleuca
100594390 Nomascus leucogenys
100715511 Cavia porcellus
101116630 Ovis aries
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