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F11 encodes coagulation factor XI of the blood coagulation cascade.
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Data indicate four new factor XI (FXI) gene defects potentially causing a functional deficiency and the duplication of 1653 bp involving exons 8 and 9.
In this prospective cohort of elderly adults, there was no statistically significant association of higher FXI levels with incident coronary heart disease and stroke.
Higher FIX antigen levels are associated with incident coronary heart disease in blacks but not in whites; the association of FXI levels with ischemic stroke is slightly attenuated after adjusting for stroke risk factors.
High molecular weight kininogen has an inhibitory effect on nucleic acid-supported fXI activation and may function as a negative regulator of fXI activation.
FXI has a role in promoting a vascular coagulation-inflammatory circuit in arterial hypertension
thrombin activatable fibrinolysis inhibitor (zeige CPB2 ELISA Kits) pathway impairment, largely caused by a hitherto unknown TAFIa resistance, appears to be one main cause of decreased fibrinolytic resistance in FXI deficiency
Three loci showed robust, replicating association with circulating FXI levels: KNG1 (zeige KNG1 ELISA Kits) (rs710446, P-value = 2.07 x 10-302), F11 (rs4253417, P-value = 2.86 x 10-193), and a novel association in GCKR (zeige GCKR ELISA Kits) (rs780094, P-value = 3.56 x10-09), here for the first time implicated in FXI regulation. The two first SNPs (rs710446 and rs4253417) also associated with partial thromboplastin (zeige F3 ELISA Kits) time
The rs710446 and five low-frequency variant sets in KNG1 (zeige KNG1 ELISA Kits) with FXI level variation of Factor XI were significant after multiple testing correction and permutation.
Exploring the global landscape of genetic variation in coagulation factor XI deficiency
Structures of FXI in complex with the laminin-derived peptide EFPDFP and a DFP (zeige PPCS ELISA Kits) peptide from the random screen demonstrated binding in the same pocket, although in a slightly different conformation, thus revealing some flexibility in the molecular interactions of the FXI apple 2 domain.
Sequence analysis of the bovine coagulation factor XI (F11) gene revealed an unusually high number of non-synonymous mutations. However, none of the mutations in the F11 gene were concordant with Bovine neonatal pancytopenia status.
Insertion of 15 nucleotides in the F11 gene is the causative mutation for factor XI deficiency in Japanese black cattle.
The molecular basis of coagulopathy has been recognized in Holstein cattle as a 76-bp insertion in the coding region of the FXI gene
FXI protects against sepsis derived from Streptococcus pneumoniae or Klebsiella pneumoniae pneumonia at least in part by enhancing the phagocytic capacity of neutrophils by a mechanism that is independent of activation via FXIIa.
FXI attenuates part of the allergic response to repeated administration of house dust mite in the airways by a mechanism that is independent of activation via FXII (zeige F12 ELISA Kits).
Thrombin (zeige F2 ELISA Kits)-independent contribution of tissue factor (zeige F3 ELISA Kits) to inflammation and cardiac hypertrophy in a mouse model of sickle cell disease.
FXI deprivation was shown to slow down atherogenesis in Apoe (zeige APOE ELISA Kits) knockout mice.
anion-binding sites on FXIa that are required for expression of heparin's cofactor activity during protease inhibition by antithrombin (zeige SERPINC1 ELISA Kits) are also required for expression of polyP cofactor activity during FXI activation
Data conclude that within the mouse F11, Klkb1, Cyp4v3 gene cluster, F11 and Cyp4v3 frequently display striking parallel transcriptional responses suggesting the presence of shared regulatory elements.
Studies indicate that targeting factor XI (FXI) by knocking out the gene prevents arterial and vein thrombosis.
Protective roles for fibrin, tissue factor (zeige F3 ELISA Kits), plasminogen activator inhibitor-1 (zeige SERPINE1 ELISA Kits), and thrombin activatable fibrinolysis inhibitor (zeige CPB2 ELISA Kits), but not factor XI, during defense against the gram-negative bacterium Yersinia enterocolitica.
fXI and fXII (zeige F12 ELISA Kits) contribute to thrombus formation even when factor VIIa/tissue factor (zeige F3 ELISA Kits) initiates thrombosis.
Gene targeting of tissue factor (zeige F3 ELISA Kits), factor X, and factor VII (zeige TH ELISA Kits) in mice: their involvement in embryonic development
This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.
, plasma thromboplastin antecedent
, coagulation factor XI (plasma thromboplastin antecedent)
, factor XI
, platelet coagulation factor XI
, blood coagulation factor XI
, coagulation factor XI
, coagulation factor XI-like