Chromobox Homolog 4 Proteine (CBX4)

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Zusätzlich bieten wir Ihnen CBX4 Antikörper (132) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CBX4 12418 O55187
CBX4 8535 O00257
Ratte CBX4 CBX4 501403  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 60 Days
Wheat germ Human GST tag 2 μg 11 bis 12 Tage

CBX4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,

Weitere Proteine zu Chromobox Homolog 4 (CBX4) Interaktionspartnern

Mouse (Murine) Chromobox Homolog 4 (CBX4) Interaktionspartner

  1. The Cbx4 plays a crucial role in the p63-regulated program of epidermal differentiation, maintaining the epithelial identity and proliferative activity in KCs via repression of the selected nonepidermal lineage and cell cycle inhibitor genes.

  2. Data indicate an important role of chromobox homolog 4 protein CBX4 in production of high quality oocytes.

  3. Cbx4 is a crucial regulator for the generation and maintenance of the thymic epithelium and, hence, for thymocyte development.

  4. SUMO interaction motif 2 (SIM2) is crucial for many of the documented Pc2 functions, which converge on determining its E3 ligase activity.

  5. Our results suggest that Cbx4 functions as a SUMO E3 ligase for Dnmt3a and it might be involved in the functional regulation of DNA methyltransferases by promoting their SUMO modification.

Human Chromobox Homolog 4 (CBX4) Interaktionspartner

  1. CBX4 is up-regulated in breast cancer tissues and while its over-expression promotes cell proliferation, its knockdown suppresses cell proliferation in breast cancer cells. Furthermore, CBX4 mediates miR-129-5p-induced inhibition of cell proliferation and negatively correlates with the expression of miR-129-5p expression.

  2. Data suggest that CBX4 expression is up-regulated in breast cancer and is correlated with unfavorable overall survival; CBX4 promotes cell growth and migration via transcriptionally suppressing expression of miR137 to trigger Notch1 signaling pathway. (CBX4 = chromobox homolog 4; miR137 = microRNA 137; Notch1 = neurogenic locus notch homolog protein-1)

  3. Data show that USP26 interacts with PRC1 components chromobox (CBX)-containing proteins CBX4 and CBX6.

  4. Data show that SUMO E3 ligase CBX4 sumoylates subpopulation of CtIP to regulate recruitment to breaks and resection.

  5. provide evidence to show that CBX4 may serve as a tumor suppressor in colorectal carcinoma by recruiting HDAC3 to the Runx2 promoter to impede Runx2 expression

  6. Cbx4 is an independent prognostic factor for HCC patients, and the patients with high Cbx4 expression should receive postoperative TACE treatment to improve their survival

  7. our study demonstrated that miR-195 acts as a tumor suppressor by directly targeting CBX4 in hepatocellular carcinoma

  8. Role of Cbx4 in migration and metastasis of a metastatic hepatocellular carcinoma cell line. Results show that Cbx4 overexpression increases the in vitro vessel formation of vascular endothelial cells in its SUMO interaction motifs-dependent manner.

  9. The presence of CBX4-GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.

  10. High cytoplasmic expression of CBX4 is associated with hepatocellular carcinoma.

  11. our findings demonstrate that Cbx4 plays a critical role in tumor angiogenesis by governing HIF-1alpha protein

  12. ASXL1 associates with the PRC2 and loss of ASXL1 in vivo collaborates with NRASG12D to promote myeloid leukemogenesis.

  13. High Polycomb repressive complex protein is associated with mesothelioma.

  14. Pc2, methylation controls the protein's interaction with two distinct ncRNAs, TUG1 and NEAT2, which results in the exclusive subnuclear localization of methylated and unmethylated Pc2 in Polycomb bodies and interchromatin granules, respectively.

  15. plays role in regulation of epidermal stem cell proliferation and senescence

  16. Data show that PRC2 can integrate information provided by pre-existing histone modifications to accurately tune its enzymatic activity within a particular chromatin context.

  17. the hPc2-induced SUMOylation of alpha-synuclein could function as a cytoprotector by increasing alpha-synuclein aggregate formation within fibroblast cells.

  18. 14-3-3 protein binding to chromobox homolog 4 (CBX4) appears to modulate the interaction between CBX4 and the BMI1/PCGF components of polycomb recessive complex 1, but has no effect on CBX4-RING1/RNF2 interaction

  19. A phage display screen using the N-terminus of JARID1B as bait identified one of the JARID1B interacting proteins, namely PcG protein (Polycomb group) hPc2.

  20. Huntingtin is a novel stimulator of polycomb repressive complex 2.

CBX4 Protein Überblick

Protein Überblick

E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones\; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Genbezeichner und Symbole assoziert mit Chromobox Homolog 4 Proteine (CBX4)

  • chromobox 4 (CBX4)
  • chromobox 4 (Cbx4)
  • chromobox 4 S homeolog (cbx4.S)
  • chromobox homolog 4 (CBX4)
  • chromobox homolog 4 (Pc class homolog, Drosophila) (cbx4)
  • cbx4-a Protein
  • im:6911625 Protein
  • MPc2 Protein
  • NBP16 Protein
  • PC2 Protein
  • XPolycomb Protein
  • zgc:158588 Protein

Bezeichner auf Proteinebene für Chromobox Homolog 4 Proteine (CBX4)

chromobox homolog 4 , E3 SUMO-protein ligase CBX4 , chromobox protein homolog 4 , polycomb 2 homolog , NS5ATP1-binding protein 16 , Pc class 2 homolog , chromobox homolog 4 (Pc class homolog, Drosophila) , chromobox homolog 4 (Pc class homolog) , chromobox homolog 4 (Polycomb) , chromobox protein (CHCB3) , chromobox-like protein 4 , polycomb 2

744720 Pan troglodytes
12418 Mus musculus
8535 Homo sapiens
394294 Xenopus laevis
395354 Gallus gallus
608556 Canis lupus familiaris
767865 Bos taurus
501403 Rattus norvegicus
573110 Danio rerio
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