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CBX2 encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones.
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the compaction region of CBX2 plays a key role in establishing proper axial patterning, thereby expanding the functional regions of this protein.
We find that the N-terminus of Cbx2 is needed for its recruitment to mitotic chromosomes, whereas the C-terminus is required for its immobilization.
Cbx2 targets PRC1 (zeige PRC1 Antikörper) to constitutive heterochromatin in mouse zygotes in a parent-of-origin-dependent manner.
This study implicates Cbx2 in testis differentiation through regulating Sry (zeige SRY Antikörper) gene expression.
Data show that Polycomb repressive complex 2 is necessary to maintain normal levels of OGT and for the correct cellular distribution of O-GlcNAc.
Zfp277 in the transcriptional regulation of the Ink4a/Arf locus and the recruitment of PRC1 to the Ink4a/Arf locus
these results suggest that the binding specificity of Cbx2 protein for methylated histones is regulated by phosphorylation.
murine geminin (zeige GMNN Antikörper) associates transiently with members of the Hox (zeige MSH2 Antikörper)-repressing polycomb complex, with the chromatin of Hox (zeige MSH2 Antikörper) regulatory DNA elements and with Hox (zeige MSH2 Antikörper) proteins
Polycomb protein M33 controls critical expansion of B- and T-lymphocyte precursors
The Polycomb M33 gene is an essential upstream regulator of Ad4BP/SF1 (zeige NR5A1 Antikörper).
These results suggest that CBX2's phosphorylation is critical for its transcriptional repression of target genes.
Data show that basal-like subgroup was enriched for aggressive tumors and somatic mutations in trithorax (zeige MLLT1 Antikörper)-group genes and it overexpressed polycomb genes EZH2 (zeige EZH2 Antikörper) and CBX2.
CBX2 role in the sex development cascade is to stimulate the male pathway and concurrently inhibit the female pathway.
CBX2 upregulation and amplification significantly correlated with metastatic progression and lower overall survival in many cancer types, particularly those of the breast
This study does not support CBX2 gene disruption as a common cause of gonadal gonadal disorders of sex development.
Two distinct mechanisms are involved in CBX2-mediated gene silencing. The short CBX2-2 isoform would repress the transcription in a PRC1 (zeige PRC1 Antikörper)-independent fashion, whereas gene repression by the long CBX2-1 isoform is mediated by the PRC1 (zeige PRC1 Antikörper) protein complex.
CDYL (zeige CDYL Antikörper) functions as a molecular bridge between PRC2 and the repressive chromatin mark H3K27me3, forming a positive feedback loop to facilitate the establishment and propagation of H3K27me3 modifications along the chromatin
hPc2 (zeige ELAC2 Antikörper) serves as a SUMO E3 ligase (zeige PIAS1 Antikörper) for cystathionine beta-synthase (zeige CBS Antikörper), increasing the efficiency of sumoylation.
This gene encodes a component of the polycomb multiprotein complex, which is required to maintain the transcriptionally repressive state of many genes throughout development via chromatin remodeling and modification of histones. Disruption of this gene in mice results in male-to-female gonadal sex reversal. Mutations in this gene are also associated with gonadal dysgenesis in humans. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
chromobox homolog 2
, modifier 3 protein
, chromobox protein homolog 2-like
, chromobox homolog 2 (Pc class homolog, Drosophila)
, chromobox protein homolog 2
, M33 polycomb-like protein
, hromobox homolog 2
, Pc class homolog
, cell division cycle associated 6
, modifier 3
, Polycomb homolog Pc1
, chromobox homolog 2 (Pc class homolog)