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The protein encoded by CHDH is a choline dehydrogenase that localizes to the mitochondrion. Zusätzlich bieten wir Ihnen Choline Dehydrogenase Antikörper (45) und Choline Dehydrogenase Kits (4) und viele weitere Produktgruppen zu diesem Protein an.
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The authors found that BMP2b and Chordin diffuse and rapidly form extracellular protein gradients, Chordin does not modulate the diffusivity or distribution of BMP2b, and Chordin is not required to establish peak levels of BMP signaling.
activation of the FGF signaling pathway induces the formation of a dorsal axis with a complete head structure through the expression of chd (zeige CHRD Proteine) and subsequent maintenance of dkk1b (zeige DKK1 Proteine) expression levels.
Binding of CV2 (zeige BMPER Proteine) to Chordin (zeige CHRD Proteine) promotes BMP-2 (zeige BMP4 Proteine) signaling.
Targeted knockdown of Sox17 (zeige SOX17 Proteine) and Chd (zeige CHRD Proteine) in dorsal forerunner cells led to aberrant Left-Right (L-R) asymmetry establishment, as visualized by the expression of southpaw and lefty (zeige LEFTY2 Proteine), and heart and pancreas placement in the embryo.
Chl (zeige CHRDL2 Proteine), like Chd (zeige CHRD Proteine), dorsalizes embryos upon overexpression and is cleaved by BMP1 (zeige BMP1 Proteine); loss-of-function experiments show Chl (zeige CHRDL2 Proteine) serves as a BMP antagonist with functions that overlap and are redundant with those of Chd (zeige CHRD Proteine) in forming the dorsoventral axis.
Data show that The inhibition of Brorin-like functions in zebrafish resulted in the impairment of neural development.
by regulating the expression of her5, the Bmp2b (zeige BMP4 Proteine)/Chordin (zeige CHRD Proteine) gradient directs the anteroposterior patterning of endoderm in zebrafish embryos
chd, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Twisted (zeige POMT2 Proteine) gastrulation enhances BMP signaling through chordin (zeige CHRD Proteine) dependent and independent mechanisms
specification of anterior neural tissue requires later activities of Chordin (zeige CHRD Proteine) and mesodermal factors.
There is no correlation between single CHDH rs893363 and CHDH rs2289205 polymorphisms and the incidence of intrauterine fetal death.
CHDH gene is located at chromosome 3p21.1, a risk region implicated in previous brains of bipolar disorder genome-wide association studies
In genotypic combination analysis considering PEMT (zeige PEMT Proteine) -744GG/CHDH +432GG/BHMT (zeige BHMT Proteine) +742GG as the reference combination, PEMT (zeige PEMT Proteine) -744GC/CHDH +432GG/BHMT (zeige BHMT Proteine) +742GG genotypic combination was significantly higher in mothers of a down syndrome child compared with that in control mothers with an odds ratio of 2.061 (95% CI: 1.10-3.86, P=0.0342).
CHDH is not a substrate of PARK2 (zeige PARK2 Proteine) but interacts with SQSTM1 (zeige SQSTM1 Proteine) independently of PARK2 (zeige PARK2 Proteine) to recruit SQSTM1 (zeige SQSTM1 Proteine) into depolarized mitochondria
the PEMT (zeige PEMT Proteine) -774G>C and CHDH +432G>T polymorphisms were associated with sperm concentration. This finding suggests a possible influence of these genes on sperm quality
CHDH and PLD2 (zeige PLD2 Proteine) as novel candidate genes, the nucleotide variants of which could be associated with the risk of tooth agenesis.
CHDH A119C and MTHFR (zeige MTHFR Proteine) C677T play an important role in modulating the homocysteine levels in Indian population.
HOXB13 (zeige HOXB13 Proteine), IL17BR, and CHDH are regulated by estrogen in breast cancer
single nucleotide polymorphisms of choline-metabolizing genes, PEMT (zeige PEMT Proteine) -774G>C (rs12325817) and CHDH +432G>T (rs12676), were found be related to breast cancer risk
Data, including data from studies using transgenic/knockout mice, suggest that betaine accumulates during oocyte meiotic maturation; the mechanism appears to be transient activation of Chdh; Chdh is again inactive in the zygote (that is, after fertilization).
Loss of CHDH activity resulted in decreased testicular betaine and increased choline and PCho concentrations; impaired fertility was due to diminished sperm motility in the Chdh(-/-) males
The protein encoded by this gene is a choline dehydrogenase that localizes to the mitochondrion. Variations in this gene can affect susceptibility to choline deficiency. A few transcript variants have been found for this gene, but the full-length nature of only one has been characterized to date.
, dino (din)
, protein chordino
, choline dehydrogenase, mitochondrial
, choline dehydrogenase
, Choline dehydrogenase