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The protein encoded by CLCA4 belongs to the calcium sensitive chloride conductance protein family.
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CLCA4 and CLCA2 (zeige CLCA2 Antikörper) play complementary but distinct roles in epithelial differentiation
CLCA4 modulates the capability to express residual chloride secretion in colonic tissue.
CLCA1 (zeige CLCA1 Antikörper) and CLCA4 may have roles as modulators of the gastrointestinal basic defect in cystic fibrosis (zeige S100A8 Antikörper)
cleavage of the mCLCA6 E157Q variant protein is zinc-dependent and sensitive to metalloprotease inhibitors, suggesting secondary cleavage by a metalloprotease.
mCLCA6 is colocalized with CFTR (zeige CFTR Antikörper) at the surface of colonic crypt cells
Deleterious mutation of the CLCA4b gene is not associated with cystic fibrosis (zeige S100A8 Antikörper) phenotype.
The porcine chloride channel (zeige CLCA1 Antikörper) calcium-activated family member pCLCA4a mirrors lung expression of the human hCLCA4.
The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding.
chloride channel accessory 4
, calcium-activated chloride channel regulator 4
, chloride channel calcium activated 4
, chloride channel calcium activated 6 protein
, chloride channel regulator 4
, chloride channel, calcium activated, family member 4
, parturition-related protein PRP3
, calcium-activated chloride channel family member 4
, calcium-activated chloride channel protein 2
, calcium activated chloride channel
, calcium-activated chloride channel regulator 6