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The protein encoded by CHIA degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. Zusätzlich bieten wir Ihnen Chitinase, Acidic Antikörper (50) und Chitinase, Acidic Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
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we showed that M at the position 61 is highly conserved in the many mammals other than orangutan and humans. In addition, introduction of M61R and M61I to WT mouse AMCase lead to a significant reduction of its chitinolytic activity. Taken together, our present and previous data by Seibold et al. (2009) indicate that G339T (R61M) in humans is associated with asthma protection in the fashion of gain of function
This is the first report on the association between low-frequency and common variants in the chitinases-related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population.
loss of acidic chitinase expression is a promising marker for corpus atrophy
results showed that the expression of AMCase and CHIT-1 were differently modulated in monocyte macrophages at different stage of maturation. The behavior of these two active chitinase suggests that in the immune response their role is complementary.
study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study; also functional effect of the rs3818822 polymorphism on AMCase levels and activity was demonstrated
Report increased CSF chitinase levels in patients with neuromyelitis optica and relapsing remitting multiple sclerosis.
A ten base pair insertion in the second exon in the 5'UTR (zeige UTS2R ELISA Kits) region of the AMCase gene may modify the gene expression and thus may affect the severity of asthma.
AMCase and eotaxin-3 (zeige CCL26 ELISA Kits) may be important mediators in the pathogenesis of nasal polyps. The increased AMCase and eotaxin-3 (zeige CCL26 ELISA Kits) might lead to nasal polyp formation and growth.
Results showed the presence of CHIT1 and AMCase mRNA in gastric mucosa and the correlation with the presence of H. pylori was significant only for CHIT1 but not for AMCase expression.
Environmental exposure to fungi does not modify the effect of CHIA SNPs on severe asthma exacerbations
The results indicate that mouse AMCase catalyzes hydrolysis as well as transglycosylation and suggest that this enzyme can play a novel role under physiological conditions in peripheral tissues, such as the lungs.
AMCase-deficient mice exhibit premature morbidity and mortality, concomitant with accumulation of environmentally derived chitin polymers in the airways and expression of pro-fibrotic cytokines. Over time, these mice develop spontaneous pulmonary fibrosis.
Data show that acidic mammalian chitinase (AMCase) functions as a critical initiator of protective type 2 responses to intestinal nematodes, but is largely dispensable for allergic responses in the lung.
AMCase expression was significantly decreased in experimental autoimmune encephalitis mice compared to PBS (zeige TSPO ELISA Kits)-controls.
Protein A-mouse acidic mammalian chitinase-V5-His expressed in periplasmic space of Escherichia coli possesses chitinase functions comparable to CHO (zeige COL11A1 ELISA Kits)-expressed protein.
AMCase mRNA is a major transcript in mouse stomach acting as a digestive enzyme that breaks down polymeric chitin and as part of the host defense against chitin-containing pathogens in the gastric contents.
Although exposure to allergen stimulates the expression of AMCase and increased chitinolytic activity in murine airways, the overexpression or inhibition of AMCase exerts only a subtle impact on AAD.
findings show that acidic mammalian chitinase is induced via a T helper-2 (Th2)-specific, interleukin-13 (IL-13 (zeige IL13 ELISA Kits))-mediated pathway in epithelial cells and macrophages in an aeroallergen asthma model
AMCase provides the first positive molecular marker of distal Clara cell secretory protein (zeige SCGB1A1 ELISA Kits)-expressing cells under these conditions.
The protein encoded by this gene degrades chitin, which is found in the cell wall of most fungi as well as in arthropods and some nematodes. The encoded protein can also stimulate interleukin 13 expression, and variations in this gene can lead to asthma susceptibility. Several transcript variants encoding a few different isoforms have been found for this gene.
, acidic mammalian chitinase-like
, acidic mammalian chitinase
, lung-specific protein TSA1902
, chitin-binding protein b04
, acidic chitinase
, eosinophil chemotactic cytokine
, small acid mammalian chitinase