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CCL17 is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16.
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Human CCL17 ELISA Kit für Sandwich ELISA - ABIN625091
García, Cidoncha, Bote, Hinchado, Ortega: Altered profile of chemokines in fibromyalgia patients. in Annals of clinical biochemistry 2014
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This review presents key clinical studies of Multiple sclerosis together with experimental studies in animals that have demonstrated functional roles of CCR4 (zeige CCR4 ELISA Kits), CCL17, and CCL22 (zeige CCL22 ELISA Kits) in experimental autoimmune encephalomyelitis pathogenesis. [review]
Taken together, our data showed a likely positive feedback mechanism of enhanced IL-6 (zeige IL6 ELISA Kits) production in ectopic milieu. The high levels of IL-6 (zeige IL6 ELISA Kits) in the peritoneal cavity stimulate the expression of CCL17 in endometrial stromal cells by activating JNK (zeige MAPK8 ELISA Kits) signal pathway, and then, CCL17 further induces CCR4 (zeige CCR4 ELISA Kits) expression on macrophages, which eventually leads to an increase in IL-6 (zeige IL6 ELISA Kits) production via NF-kappaB (zeige NFKB1 ELISA Kits) activation.
Data suggest that high levels of CCL17 and CCL22 (zeige CCL22 ELISA Kits) in endometrium in women with endometriosis promote (1) recruitment of Tregs, (2) immunosuppression of Tregs, and (3) angiogenesis in endometrium. (Tregs = regulatory T cells)
Serum TARC levels correlate well with indicators of systemic inflammation and of disease severity among patients with a drug eruption except SJS (zeige HSPG2 ELISA Kits)/TEN. Serum TARC may be a prognostic biomarker of severity of inflammation in drug eruptions.
TARC production in HaCaT keratinocytes through the interaction between IL-22 (zeige IL22 ELISA Kits) and IL-22Ralpha facilitates T-cell migration in atopic dermatitis caused by house dust mites.
TARC is a candidate biomarker for PTSD only in males.
High CCL17 expression is associated with colon cancer cell migration.
GM-CSF (zeige CSF2 ELISA Kits) can mediate inflammation and pain by regulating IRF4 (zeige IRF4 ELISA Kits)-induced CCL17 production
Based on the ADEPT study data set, we report that airway mucosal expression of CCL26 (zeige CCL26 ELISA Kits) was a robust discriminator of type 2 inflammation from healthy nonatopic subjects. Furthermore, airway mucosal CCL26 (zeige CCL26 ELISA Kits) expression was best identified by using a panel of clinical biomarkers, including Feno values, bEOS counts, and expression of 2 novel markers, sCCL17 and sCCL26
Low CCL17 expression is a potential independent adverse prognostic biomarker for recurrence and survival of patients with clear cell renal cell carcinoma after nephrectomy.
Study identifies CC chemokine (zeige CCL1 ELISA Kits) ligand 17 as a unique modulator of experimental autoimmune encephalomyelitis (EAE) pathogenesis regulating dendritic cell trafficking as well as peripheral Treg cell expansion in EAE.
the M2 macrophage chemokine CCL17 was identified as an essential factor for enhanced survival in the absence of CB2, because CCL17 x Cnr2 double-deficient mice were fully susceptible to experimental cerebral malaria.
Aged mice had similar levels of IL-1beta (zeige IL1B ELISA Kits), TNF (zeige TNF ELISA Kits), IFN-gamma (zeige IFNG ELISA Kits), IL-17 (zeige IL17A ELISA Kits), and granulocyte colony-stimulating factor (zeige CSF3 ELISA Kits) following S. pneumoniae infection, compared with young mice, but increased levels of the chemokines CXCL9 (zeige CXCL9 ELISA Kits), CXCL12 (zeige CXCL12 ELISA Kits), CCL3 (zeige CCL3 ELISA Kits), CCL4 (zeige CCL4 ELISA Kits), CCL5 (zeige CCL5 ELISA Kits), CCL11, and CCL17.
that effective engagement of CCR4 (zeige CCR4 ELISA Kits) by CCL17 involves two distinct binding domains and interaction with both is required for signaling
murine tumor-associated neutrophils secrete significant amounts of CCL17. Migration assays showed recruitment of T-regs by tumor-associated neutrophils, which was inhibited with anti-CCL17 monoclonal antibodies.
TSLP (zeige TSLP ELISA Kits) activated a subset of CD11b (zeige ITGAM ELISA Kits)(+) DCs in the skin to produce CCL17, upregulate CCR7 (zeige CCR7 ELISA Kits), and migrate to the draining lymph node to initiate Th2 differentiation.
CCL17 is required for induction of intestinal inflammation in mice and has an autocrine effect on dendritic cells that promotes production of inflammatory cytokines and activation of Th1 (zeige HAND1 ELISA Kits) and Th17 cells and reduces expansion of Treg cells.
Kinetics of CCL17 mRNA expression in an allergic contact dermatitis model.
Thymus and activation-regulated chemokine (TARC)/CC chemokine (zeige CCL1 ELISA Kits) ligand (CCL) 17 accelerates wound healing by enhancing fibroblast migration.
This gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells.
C-C motif chemokine 17
, CC chemokine TARC
, T cell-directed CC chemokine
, small inducible cytokine subfamily A (Cys-Cys), member 17
, small-inducible cytokine A17
, thymus and activation-regulated chemokine
, chemokine (C-C motif) ligand 17
, chemokine CCL17/TARC
, small inducible cytokine A17
, small inducible cytokine subfamily A17
, chemokine ligand 17-like protein
, ATP-binding cassette sub-family D member 2
, ATP-binding cassette, sub-family D (ALD), member 2