anti-Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Antikörper

The protein encoded by CDC37 is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. Zusätzlich bieten wir Ihnen CDC37 Proteine (19) und CDC37 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CDC37 11140 Q16543
CDC37 12539 Q61081
CDC37 114562 Q63692
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Top anti-CDC37 Antikörper auf antikoerper-online.de

Showing 10 out of 152 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IC, IF, IP, IHC, WB Immunofluorescent analysis of CDC37 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Immunohistochemical analysis of CDC37 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert WB Observed bind size: 44KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert IF, IHC, ELISA, WB Western blot analysis of extracts from MCF-7/COS7 cells, using CDC37 (Ab-13) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using CDC37 (Ab-13) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from NIH-3T3/HT-29/RAW264.7 cells, using p50 CDC37 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from HuvEc cells, using CDC37 (Phospho-Ser13) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human placenta, using CDC37 (Phospho-Ser13) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: CDC37 Antibody [NBP1-80960] - Staining of human duodenum shows moderate cytoplasmic positivity in glandular cells. Immunocytochemistry/Immunofluorescence: CDC37 Antibody [NBP1-80960] - Staining of human cell line A-431 shows positivity in cytoplasm. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen HRP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-CDC37 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:200 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-CDC37 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min. Western blot analysis of Human HeLa cell lysates showing detection of CDC37 protein using Rabbit Anti-CDC37 Polyclonal Antibody . Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:2000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$350.90
Details
Human Kaninchen FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-CDC37 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:200 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-CDC37 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min. Western blot analysis of Human HeLa cell lysates showing detection of CDC37 protein using Rabbit Anti-CDC37 Polyclonal Antibody . Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:2000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$355.30
Details
Human Kaninchen Alkaline Phosphatase (AP) ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-CDC37 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:200 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-CDC37 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min. Western blot analysis of Human HeLa cell lysates showing detection of CDC37 protein using Rabbit Anti-CDC37 Polyclonal Antibody . Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:2000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$357.50
Details
Human Kaninchen Biotin ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-CDC37 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:200 for 12 hours at 4°C. Secondary Antibody: R-PE Goat Anti-Rabbit (yellow) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Cytoplasm. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-CDC37 Antibody. (C) Composite. Heat Shocked at 42°C for 30 min. Western blot analysis of Human HeLa cell lysates showing detection of CDC37 protein using Rabbit Anti-CDC37 Polyclonal Antibody . Primary Antibody: Rabbit Anti-CDC37 Polyclonal Antibody at 1:2000. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$359.70
Details

CDC37 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-CDC37 Antikörper

  1. Dog (Canine) Monoclonal CDC37 Primary Antibody für IF, IP - ABIN968047 : Grammatikakis, Lin, Grammatikakis, Tsichlis, Cochran: p50(cdc37) acting in concert with Hsp90 is required for Raf-1 function. in Molecular and cellular biology 1999 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal CDC37 Primary Antibody für ICC, IF - ABIN4296941 : Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013 (PubMed)

  3. Yeast (Saccharomyces cerevisiae) Polyclonal CDC37 Primary Antibody für IF, IP - ABIN2451938 : Reed: The selection of S. cerevisiae mutants defective in the start event of cell division. in Genetics 1981 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen CDC37 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Interaktionspartner

Human Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Interaktionspartner

  1. Study showed that Cdc37 gene was up-regulated in human colorectal adenocarcinoma (CRC (zeige CALR Antikörper)). Furthermore, knockdown of Cdc37 effectively reduced cell proliferation activity, enhanced apoptosis, and inhibited G1-S transition in CRC (zeige CALR Antikörper) cells, and vice versa. For the mechanism, Cdc37 increased CDK4 (zeige CDK4 Antikörper) stability to promote the phosphorylation of RB1 (zeige RB1 Antikörper), which finally promoted the progression of CRC (zeige CALR Antikörper).

  2. During the kinase chaperone cycle, Cdc37 phosphorylated at Y298 acts as a platform for docking of non-receptor tyrosine kinases through their regulatory domains to drive the coupled Hsp90 (zeige HSP90 Antikörper) phosphorylation at Y197 and specifically regulate kinase chaperoning.

  3. findings suggested that this mechanism may be exploited by the Hsp90 (zeige HSP90 Antikörper)-Cdc37 chaperone to recruit and protect intrinsically dynamic kinase clients from degradation

  4. The results suggest a re-evaluation of the role of Cdc37 in the kinase lifecycle, and suggest that such interactions potentially allow kinases to more rapidly respond to key signals while simultaneously protecting unstable kinases from degradation and suppressing unwanted basal activity.

  5. Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 (zeige HSP90 Antikörper) in hepatocellular carcinoma, reducing tumor growth.

  6. Cdc37 performs a quality control of protein kinases, including b-raf (zeige SNRPE Antikörper), where induced conformational instability acts as a "flag" for Hsp90 (zeige HSP90 Antikörper) dependence and stable cochaperone association.

  7. Ulk1 (zeige ULK1 Antikörper) promoted the degradation of Hsp90 (zeige HSP90 Antikörper)-Cdc37 client kinases, resulting in increased cellular sensitivity to Hsp90 (zeige HSP90 Antikörper) inhibitors. Thus, our study provides evidence for an anti-proliferative role of Ulk1 (zeige ULK1 Antikörper) in response to Hsp90 (zeige HSP90 Antikörper) inhibition in cancer cells

  8. The authors find that the interaction between sB-Raf (zeige RAF1 Antikörper) and the Hsp90 chaperone (zeige HSP90 Antikörper) system is based on contacts with the M domain of Hsp90 (zeige HSP90 Antikörper), which contributes in forming the ternary complex with Cdc37 as long as the kinase is not stabilized by nucleotide.

  9. Apart from these distinct Cdc37/Hsp90 interfaces, binding of the B-Raf protein kinase to the cochaperone is conserved between mammals and nematodes.

  10. Suppressing expression of the cochaperone CDC37 in hepatocellular carcinoma cells inhibits cell cycle progression and cell growth.

Mouse (Murine) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Interaktionspartner

  1. Results showed that Cdc37 acts as a bridge to direct Hsp90 (zeige HSP90 Antikörper) to the transcription factor viral P proteins of all lyssaviruses. Although Cdc37 can load P proteins onto Hsp90 (zeige HSP90 Antikörper), with or without binding to Hsp90 (zeige HSP90 Antikörper), the interaction between Cdc37 and Hsp90 (zeige HSP90 Antikörper) appears to provide additional allosterical regulation of its chaperone activity. Notably, both phosphorylated and non-P Cdc37 could facilitate Hsp90 (zeige HSP90 Antikörper)-mediated protein maturation.

  2. Niclosamide ethanolamine disrupted the interaction between cell division cycle 37 and heat shock protein 90 (zeige HSP90 Antikörper) in hepatocellular carcinoma, reducing tumor growth.

  3. A series of tyrosine phosphorylation events, involving both p50(Cdc37) and Hsp90 (zeige HSP90 Antikörper), are minimally sufficient to provide directionality to the chaperone cycle.

  4. Hsp90 (zeige HSP90 Antikörper)-Cdc37 complex acta (zeige ACTC1 Antikörper) as an endogenous regulator of noncanonical p38alpha (zeige MAPK14 Antikörper) activity.

  5. CDC37 binds to Akt (zeige AKT1 Antikörper) and HSP90 (zeige HSP90 Antikörper) in the signal transduction pathway in human tumor cells

  6. The interaction between mouse Pem and Cdc37 homolog was then confirmed by glutathione S-transferase (zeige GSTa2 Antikörper) pull-down assay, and the possible interaction model was suggested.

  7. JAK1 (zeige JAK1 Antikörper)/2 are client proteins of Hsp90 alpha (zeige HSP90AA1 Antikörper) and beta; Hsp90 (zeige HSP90 Antikörper) and CDC37 play a critical role in types I and II interferon (zeige IFNA Antikörper) pathways

  8. This growth inhibition is partially rescued by expression of ectopic Gli1 (zeige GLI1 Antikörper), suggesting that Fu may contribute to enhance Hh signaling activity in cancer cells.

Cow (Bovine) Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) Interaktionspartner

  1. Cdc37 has a direct regulatory interaction with endothelial nitric oxide synthase (eNOS (zeige NOS3 Antikörper)) and may play an important role in mediating the eNOS (zeige NOS3 Antikörper) protein complex formation.

CDC37 Antigen-Profil

Protein Überblick

The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.

Genbezeichner und Symbole assoziert mit CDC37

  • CG12019 gene product from transcript CG12019-RA (Cdc37) Antikörper
  • cell division cycle 37 homolog (Cdc37) Antikörper
  • Hsp90 co-chaperone Cdc37 (cdc37) Antikörper
  • Hsp90 co-chaperone Cdc37 (AFUA_4G10010) Antikörper
  • Cdc37p (CDC37) Antikörper
  • cell division cycle 37 (CDC37) Antikörper
  • cell division cycle 37 (Cdc37) Antikörper
  • Afu4g10010 Antikörper
  • cdc37 Antikörper
  • CG12019 Antikörper
  • CPDR-1 Antikörper
  • CPDR-2 Antikörper
  • Dmel\\CG12019 Antikörper
  • DROCPDR Antikörper
  • E(sev)3B Antikörper
  • p50 Antikörper
  • p50Cdc37 Antikörper

Bezeichner auf Proteinebene für CDC37

CG12019-PA , Cdc37-PA , cdc37 protein , hsp90 co-chaperone Cdc37 , Hsp90 co-chaperone Cdc37 , hypothetical protein , CDC37 (cell division cycle 37, S. cerevisiae, homolog) , CDC37 cell division cycle 37 homolog , cell division cycle 37 homolog , hsp90 chaperone protein kinase-targeting subunit , CDC37 (cell division cycle 37 S. cerevisiae homolog) , p50Cdc37 , CDC37 cell division cycle 37 protein , CDC37 homolog , cell division cycle 37 protein , cell division cycle control protein 37

GENE ID SPEZIES
38232 Drosophila melanogaster
724675 Apis mellifera
2541293 Schizosaccharomyces pombe 972h-
3509722 Aspergillus fumigatus Af293
3639210 Candida albicans SC5314
11140 Homo sapiens
12539 Mus musculus
114562 Rattus norvegicus
484955 Canis lupus familiaris
100141402 Sus scrofa
520883 Bos taurus
395430 Gallus gallus
Ausgewählte Anbieter für anti-CDC37 (CDC37) Antikörper
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