Cell Division Cycle 34 Homolog (S. Cerevisiae) Proteine (CDC34)

The protein encoded by CDC34 is a member of the ubiquitin-conjugating enzyme family. Zusätzlich bieten wir Ihnen CDC34 Antikörper (58) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CDC34 997 P49427
Maus CDC34 CDC34 216150 Q8CFI2
Ratte CDC34 CDC34 299602  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag   3 nmol Anmelden zum Anzeigen 2 bis 3 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
Escherichia coli (E. coli) Human His tag   100 μg Anmelden zum Anzeigen 2 bis 3 Tage
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 10 bis 12 Tage
Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 9 bis 11 Tage
k.A. Unkonjugiert   1 mg Anmelden zum Anzeigen 6 bis 8 Tage
Human Unkonjugiert   1 mg Anmelden zum Anzeigen 6 Days

CDC34 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,

Weitere Proteine zu Cell Division Cycle 34 Homolog (S. Cerevisiae) (CDC34) Interaktionspartnern

Human Cell Division Cycle 34 Homolog (S. Cerevisiae) (CDC34) Interaktionspartner

  1. study finds that mutation of the catalytically active cysteine to serine (C93S) results in the reduced ubiquitination, increased stability, and attenuated degradation rate of CDC34; Through semi-quantitative proteomics, identified the CDC34-interacting proteins and discovered that the wild-type and mutant proteins have many differentially interacted proteins

  2. Study shows that Ube2R1/2 forms a salt bridge interaction between a conserved Asp residue on Ube2R1/2 and acceptor ubiquitin residue Arg 54 and that perturbation of this interaction leads to the severe loss of UbeR2 activity. Results also provide new insight into how the Ube2R1/2 acidic loop may participate in catalysis.

  3. ubiquitin binding by the acidic loops of Ube2g1 and Ube2r1 enzymes distinguishes their Lys-48-ubiquitylation activities

  4. We discuss how these results can explain the rapid association of Cdc34 and SCF.

  5. Here we have investigated how the acidic loop in human Cdc34 promotes ubiquitination, identifying two key molecular events during which the acidic loop exerts its influence

  6. These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.

  7. Tristetraprolin promotes an increase in expression of mature let-7, which leads to the inhibition of let-7 target gene CDC34 expression and suppresses cell growth.

  8. Data show that anaphase-promoting complex or cyclosome (APC/C)-mediated multiple monoubiquitylation targeting cyclin B1 for degradation.

  9. work provides the first structural details that show how the C-terminus of CDC34 might direct a thiolester-bound Ub to control polyubiquitin chain formation

  10. the human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF-dependent ubiquitination

  11. COP9 signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP)-mediated degradation

  12. determined that a ubiquitin (Ub) fused at I kappaB alpha K21 acts as a receptor, directing Cdc34 for rapid and efficient K48-linked Ub chain synthesis that depends on SCF(beta TrCP2) and the substrate's N terminus.

  13. degraded by HSV-1 ICP0 while stabilizing cyclins D1 and D3

  14. antisense oligonucleotides targeting the human ubiquitin-conjugating enzyme Cdc34 downregulate its expression, inhibit the degradation of p27Kip1, and prevent cellular proliferation

  15. although a Cdc34 mutant bearing a deletion of the C-terminal 36 amino acids (Cdc34 1-200) was efficiently charged with ubiquitin by E1, it was severely reduced for the ability to ubiquitinate p27(Kip1) in vitro compared to wildtype Cdc34

  16. Data suggest that the Skp1.CUL1.F-box-mediated polyubiquitination reaction may require the conversion of Cdc34 from an inactive monomer to a highly active dimeric form.

  17. in vivo phosphorylation sites on budding yeast Cdc34 (yCdc34; Ser207 and Ser216) and human Cdc34 (hCdc34 Ser203, Ser222 and Ser231) to serine residues in the acidic tail domain, a region that is critical for Cdc34's cell cycle function

  18. In tissue culture cells, Uba6 is required for charging a previously uncharacterized Uba6-specific E2 (Use1), whereas Ube1 is required for charging the cell-cycle E2s Cdc34A and Cdc34B

  19. These findings support the hypothesis that human Cdc34 S95 and E108/E112 are required to position the donor ubiquitin optimally for catalysis, in a manner that might depend on E2 dimerization.

  20. cisplatin increased ATF5 protein expression via preventing its ubiquitin-dependent degradation, which might be associated with its promoting the nucleus-to-cytoplasm translocation of E2 ubiquitin-conjugating enzyme Cdc34

CDC34 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.

Genbezeichner und Symbole assoziert mit CDC34

  • cell division cycle 34 (CDC34)
  • cell division cycle 34 (Cdc34)
  • cell division cycle 34 L homeolog (cdc34.L)
  • cell division cycle 34 (cdc34)
  • SCF E2 ubiquitin-protein ligase catalytic subunit CDC34 (CDC34)
  • SCF E2 ubiquitin-protein ligase catalytic subunit (CDC34)
  • cell division cycle 34 homolog (S. cerevisiae) b (cdc34b)
  • AI327276 Protein
  • CDC34 Protein
  • DNA6 Protein
  • e2-cdc34 Protein
  • fb34h09 Protein
  • ubc3 Protein
  • UBCH3 Protein
  • ube2r1 Protein
  • wu:fb34h09 Protein
  • wu:fe17e09 Protein
  • zgc:91847 Protein

Bezeichner auf Proteinebene für CDC34

cell division cycle 34 homolog , ubiquitin carrier protein , ubiquitin-conjugating enzyme E2 R1 , ubiquitin-conjugating enzyme E2-32 KDA complementing , ubiquitin-conjugating enzyme E2-CDC34 , ubiquitin-protein ligase R1 , E2-CDC34 , ubiquitin-conjugating enzyme Cdc34 , ubiquitin-conjugating enzyme E2-32 kDa complementing , serine protease , cell division cycle 34 homolog (S. cerevisiae) , hypothetical protein , fe17e09 , ubiquitin-conjugating enzyme

997 Homo sapiens
216150 Mus musculus
299602 Rattus norvegicus
379298 Xenopus laevis
425483 Gallus gallus
448013 Xenopus (Silurana) tropicalis
476759 Canis lupus familiaris
616156 Bos taurus
851624 Saccharomyces cerevisiae S288c
3637028 Candida albicans SC5314
100723029 Cavia porcellus
436961 Danio rerio
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