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The protein encoded by CDC34 is a member of the ubiquitin-conjugating enzyme family. Zusätzlich bieten wir Ihnen CDC34 Antikörper (60) und und viele weitere Produktgruppen zu diesem Protein an.
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Study shows that Ube2R1/2 forms a salt bridge interaction between a conserved Asp (zeige ASIP Proteine) residue on Ube2R1/2 and acceptor ubiquitin residue Arg 54 and that perturbation of this interaction leads to the severe loss of UbeR2 activity. Results also provide new insight into how the Ube2R1/2 acidic loop may participate in catalysis.
ubiquitin binding by the acidic loops of Ube2g1 (zeige Ube2g1 Proteine) and Ube2r1 enzymes distinguishes their Lys (zeige LYZ Proteine)-48-ubiquitylation activities
We discuss how these results can explain the rapid association of Cdc34 and SCF (zeige KITLG Proteine).
Here we have investigated how the acidic loop in human Cdc34 promotes ubiquitination, identifying two key molecular events during which the acidic loop exerts its influence
These data suggest that FBXO15 and Ube2r1 regulate P-gp expression through the ubiquitin-proteasome pathway.
Tristetraprolin (zeige ZFP36 Proteine) promotes an increase in expression of mature let-7, which leads to the inhibition of let-7 target gene CDC34 expression and suppresses cell growth.
Data show that anaphase-promoting complex or cyclosome (APC (zeige APC Proteine)/C)-mediated multiple monoubiquitylation targeting cyclin B1 (zeige CCNB1 Proteine) for degradation.
work provides the first structural details that show how the C-terminus of CDC34 might direct a thiolester-bound Ub to control polyubiquitin (zeige UBB Proteine) chain formation
the human Cdc34 carboxyl terminus contains a non-covalent ubiquitin binding activity that contributes to SCF (zeige KITLG Proteine)-dependent ubiquitination
COP9 (zeige COPS8 Proteine) signalosome protects ubiquitin-conjugating enzyme 3 (UBC3/Cdc34) from beta-transducin repeat-containing protein (betaTrCP (zeige BTRC Proteine))-mediated degradation
The protein encoded by this gene is a member of the ubiquitin-conjugating enzyme family. Ubiquitin-conjugating enzyme catalyzes the covalent attachment of ubiquitin to other proteins. This protein is a part of the large multiprotein complex, which is required for ubiquitin-mediated degradation of cell cycle G1 regulators, and for the initiation of DNA replication.
cell division cycle 34 homolog
, ubiquitin carrier protein
, ubiquitin-conjugating enzyme E2 R1
, ubiquitin-conjugating enzyme E2-32 KDA complementing
, ubiquitin-conjugating enzyme E2-CDC34
, ubiquitin-protein ligase R1
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2-32 kDa complementing
, serine protease
, cell division cycle 34 homolog (S. cerevisiae)
, hypothetical protein
, ubiquitin-conjugating enzyme