anti-Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) Antikörper

Human Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) Interaktionspartner

1. A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A (zeige PPP2R4 Antikörper)(B56), modulates APC (zeige APC Antikörper)/C(Cdc20) assembly.

2. c-Myc (zeige MYC Antikörper) is a driver when combined with kRas/Akt3 (zeige AKT3 Antikörper) oncogenic signals in gliomagenesis, whereas Cdc20 overexpression is a passenger

3. The ABBA (zeige MTSS1L Antikörper)-KEN (zeige PCNT Antikörper)-ABBA (zeige MTSS1L Antikörper) amino acid motif cassette holds the Mitotic Checkpoint (zeige BUB3 Antikörper) Complex (MCC (zeige MCC Antikörper)) onto the Anaphase-Promoting Complex-Cyclosome (APC (zeige APC Antikörper)/C) by binding the two Cdc20 molecules in the MCC (zeige MCC Antikörper)-APC (zeige APC Antikörper)/C complex.

4. It discuses the roles of Cdc20 in SAC (zeige ADCY10 Antikörper) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.

5. Prostate cancer-derived SPOP (zeige SPOP Antikörper) mutants failed to interact with Cdc20 to promote its degradation. As a result, SPOP (zeige SPOP Antikörper)-deficient prostate cancer cells with elevated Cdc20 expression became resistant to a pharmacological Cdc20 inhibitor.

6. High CDC20 expression is associated with metastatic castration-resistant prostate cancer growth and reduces chemosensitivity .

7. These results provide novel insight into the mechanisms underlying the aberrant capability of NUP98 (zeige NUP98 Antikörper) oncoproteins to interact with APC (zeige APC Antikörper)/C(Cdc20) and to interfere with its function.

8. In lung adenocarcinoma patients, overexpression of cell division cycle 20 was significantly associated with bigger primary tumor size, higher MKI67 (zeige MKI67 Antikörper) level, higher DNA ploidy level, and poor prognosis.

9. CDC20 may have a role in carcinoma of the breast, colon, endometrium, and prostate

10. Overexpression of Cdc20 may serve as an independent predictor for biochemical recurrence in patients of clinically localized prostate cancer undergoing laparoscopic radical prostatectomy without neoadjuvant therapy.

Xenopus laevis Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) Interaktionspartner

1. Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.

2. Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.

3. A role for the fizzy/cdc20 family of proteins in activation of the APC (zeige APC Antikörper)/C distinct from substrate recruitment is reported.

Mouse (Murine) Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) Interaktionspartner

1. Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.

2. The physiologically effective threshold level of Cdc20 is high for female meiosis I.

3. Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (zeige APC Antikörper)/C.

4. The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells

5. Data suggest that Mad2 (zeige MXI1 Antikörper) and BubR1 (zeige BUB1B Antikörper) must cooperate to inhibit Cdc20 activity.

6. Cdc20 is degraded through two independent degradation signals (degrons), the KEN (zeige PCNT Antikörper) box and a newly described CRY (zeige CRY2 Antikörper) box.

7. Cdc20 and securin (zeige PTTG1 Antikörper) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (zeige PTTG1 Antikörper) in preventing mitotic exit

8. Expression of the cdc20 gene is down-regulated by zif268 (zeige EGR1 Antikörper) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (zeige EGR1 Antikörper) induction may be a key component of long-lasting CNS plasticity.

9. Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes

10. findings suggest a novel function of HSF1 (zeige HSF1 Antikörper) frequently overexpressed in cancer cells, to inhibit APC (zeige APC Antikörper)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability

Pig (Porcine) Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) Interaktionspartner

1. porcine FZR1 (zeige FZR1 Antikörper) and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1