Cbl-Interacting Protein Sts-1 Proteine (STS1)

STS1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. Zusätzlich bieten wir Ihnen Cbl-Interacting Protein Sts-1 Antikörper (32) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
STS1 84959 Q8TF42
Maus STS1 STS1 72828 Q8BGG7
Ratte STS1 STS1 315579  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,626.73
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 14 bis 16 Tage
$505.35
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$888.80
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STS1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,

Weitere Proteine zu Cbl-Interacting Protein Sts-1 (STS1) Interaktionspartnern

Human Cbl-Interacting Protein Sts-1 (STS1) Interaktionspartner

  1. Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70.

  2. The results show that the interaction between STS-1 and ShcA is regulated in response to EGF receptor activation.

  3. The study reveals a role of CBL in restricting myeloid proliferation of human AML1-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.

  4. targeting Aurora B to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells

  5. These results show that TULA-2 is a target of miR-148a-3p

  6. This recovery involves the phosphorylation of p70 independent of mTOR.

  7. results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells

  8. UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity.

  9. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses.

  10. Sts-1 and Sts-2 bind to Cbl and inhibit endocytosis of receptor tyrosine kinases

  11. hsp70 inhibits apoptosis upstream and downstream of the mitochondria and is a promising therapeutic target for reversing drug-resistance in chronic myeloid leukemia-blast crisis and acute myeloid leukemia cells.

  12. TULA proteins TULA and TULA-2 regulate activity of the protein tyrosine kinase Syk

Mouse (Murine) Cbl-Interacting Protein Sts-1 (STS1) Interaktionspartner

  1. Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of Zap70.

  2. Sts-1 and Sts-2 are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.

  3. The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo.

  4. dephosphorylation of Tyr(P)(346) may be considered an important "checkpoint" in the regulation of Syk activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr(P)(346) may include deactivation of receptor-activated Syk or suppression of Syk activation by suboptimal stimulation.

  5. Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.

  6. results demonstrate the importance of STS-1 in regulating IFN-alpha-induced autophagy in B cells.

  7. The lack of TULA-2 facilitates T-cell responses to TCR/CD3 stimulation, thus exacerbating T-cell-dependent inflammation.

  8. TULA-2 negatively regulates osteoclast differentiation and function.

  9. Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase Syk interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.

  10. Ablation of TULA-2 resulted in hyperphosphorylation of Syk and its downstream effector phospholipase C-gamma2 as well as enhanced GPVI-mediated platelet functional responses.

  11. Syk is a bona fide TULA-2 substrate in platelets.

  12. Taken together, our data clearly demonstrate the ability of reversine to stimulate adipocyte differentiation, which is independent of the Akt and p70(s6k) signaling pathways.

Cbl-Interacting Protein Sts-1 (STS1) Protein Überblick

Protein Überblick

This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.

Genbezeichner und Symbole assoziert mit STS1

  • ubiquitin associated and SH3 domain containing B (UBASH3B)
  • ubiquitin associated and SH3 domain containing, B (Ubash3b)
  • 2810457I06Rik Protein
  • BB125008 Protein
  • p70 Protein
  • RGD1310357 Protein
  • Sts-1 Protein
  • STS1 Protein
  • TULA-2 Protein

Bezeichner auf Proteinebene für STS1

Cbl-interacting protein Sts-1 , SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate , T-cell ubiquitin ligand 2 , cbl-interacting protein p70 , nm23-phosphorylated unknown substrate , suppressor of T-cell receptor signaling 1 , tyrosine-protein phosphatase STS1/TULA2 , ubiquitin-associated and SH3 domain-containing protein B , STS-1

GENE ID SPEZIES
84959 Homo sapiens
72828 Mus musculus
315579 Rattus norvegicus
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