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STS1 encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. Zusätzlich bieten wir Ihnen Cbl-Interacting Protein Sts-1 Antikörper (26) und viele weitere Produktgruppen zu diesem Protein an.
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Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of ZAP70 (zeige ZAP70 Proteine).
The results show that the interaction between STS-1 and ShcA (zeige SHC1 Proteine) is regulated in response to EGF receptor (zeige EGFR Proteine) activation.
The study reveals a role of CBL (zeige CBL Proteine) in restricting myeloid proliferation of human AML1 (zeige RUNX1 Proteine)-ETOinduced leukemia, and identifies UBASH3B as a potential target for pharmaceutical intervention.
targeting Aurora B (zeige AURKB Proteine) to microtubules by UBASH3B is necessary for the timing and fidelity of chromosome segregation in human cells
These results show that TULA-2 is a target of miR (zeige MLXIP Proteine)-148a-3p
This recovery involves the phosphorylation of p70 (zeige ANXA6 Proteine) independent of mTOR (zeige FRAP1 Proteine).
results demonstrate the importance of STS-1 in regulating IFN-alpha (zeige IFNA Proteine)-induced autophagy in B cells
UBASH3B is a functional target of anti-invasive microRNA200a that is down-regulated in triple negative breast cancer. Importantly, the oncogenic potential of UBASH3B is dependent on its tyrosine phosphatase activity.
Ablation of TULA-2 resulted in hyperphosphorylation of Syk (zeige SYK Proteine) and its downstream effector phospholipase C (zeige PLC Proteine)-gamma2 as well as enhanced GPVI (zeige GP6 Proteine)-mediated platelet functional responses.
Sts-1 and Sts-2 (zeige UBASH3A Proteine) bind to Cbl (zeige CBL Proteine) and inhibit endocytosis of receptor tyrosine kinases
Data suggest that Sts1 (suppressor of T-cell receptor signaling-1) negatively regulates TCR (T-cell receptor) signaling in activated T-lymphocytes via dephosphorylation of Zap70 (zeige ZAP70 Proteine).
Sts-1 and Sts-2 (zeige UBASH3A Proteine) are not required for the immune control of murine herpesvirus 68 in a normal course of gammaherpesvirus infection.
The absence of TULA-2 and also the relative level of TULA-2 expression modulates FcgammaRIIA-mediated platelet reactivity and heparin-induced thrombocytopenia in vivo.
dephosphorylation of Tyr (zeige TYR Proteine)(P)(346) may be considered an important "checkpoint" in the regulation of Syk (zeige SYK Proteine) activation process. Putative biological functions of TULA-2-mediated dephosphorylation of Tyr (zeige TYR Proteine)(P)(346) may include deactivation of receptor-activated Syk (zeige SYK Proteine) or suppression of Syk (zeige SYK Proteine) activation by suboptimal stimulation.
Biochemical analysis identified STS-1 and STS-2 as direct phosphatases of FLT3 and c-KIT.
results demonstrate the importance of STS-1 in regulating IFN-alpha (zeige IFNA Proteine)-induced autophagy in B cells.
The lack of TULA-2 facilitates T-cell responses to TCR/CD3 (zeige CD3E Proteine) stimulation, thus exacerbating T-cell-dependent inflammation.
TULA-2 negatively regulates osteoclast differentiation and function.
Once phosphorylated, tyrosines in carboxyl terminus of protein-tyrosine kinase (zeige YES1 Proteine) Syk (zeige SYK Proteine) interact with signaling proteins, including TULA-2, a negative regulator of mast cell degranulation.
This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.
Cbl-interacting protein Sts-1
, SH3 domain-containing 70 kDa protein, suppressor of T-cell receptor signaling 1, nm23-phosphorylated unknown substrate
, T-cell ubiquitin ligand 2
, cbl-interacting protein p70
, nm23-phosphorylated unknown substrate
, suppressor of T-cell receptor signaling 1
, tyrosine-protein phosphatase STS1/TULA2
, ubiquitin-associated and SH3 domain-containing protein B