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Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2.
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In lesional epidermis of patients with lichen planus, CARD18 expression was either greatly diminished or entirely absent whereas in non-lesional areas expression was comparable to normal skin.
CARD18 expression differs in healthy and psoriatic skin; moreover, CARD18 demonstrated altered response under inflammatory conditions in healthy and psoriatic skin
CARD18 may be both a promising marker for prognosis and a target protein for treatment of gastric cancer.
Inhibits generation of IL-1-beta by interacting with caspase-1 and preventing its association with RIP2. Down-regulates the release of IL1B.
ICEBERG caspase-1 inhibitor
, caspase recruitment domain-containing protein 18
, caspase-1 inhibitor Iceberg