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CMTM3 belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules.
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this study demonstrates that knockdown of CMTM3 promotes the metastasis of gastric cancer through the STAT3 (zeige STAT3 Antikörper)/Twist1 (zeige TWIST1 Antikörper)/EMT (zeige ITK Antikörper) pathway
CMTM3 was significantly hypermethylated in colorectal cancer tissues when compared with adjacent normal colorectal tissues.
CMTM3 decreases EGFR (zeige EGFR Antikörper) expression, facilitates EGFR (zeige EGFR Antikörper) degradation, and inhibits the EGF (zeige EGF Antikörper)-mediated tumorigenicity of gastric cancer cells by enhancing Rab5 (zeige RAB5A Antikörper) activity.
CMTM3 mediates cell-cell adhesion at adherens junctions and contributes to the control of vascular sprouting by regulation VE-cadherin (zeige CDH5 Antikörper) turnover.
Overexpression of CMTM3 attenuated the tumor growth of hepatocellular carcinoma.
identified CMTM3 as a novel secretory protein released via exosomes in the prostate
study indicates that elevated CMTM3 methylation is a risk factor in male LSCC patients, especially in the patients with age over 55years and with smoking behavior
Reduced expression of CMTM3 is associated with prostate cancer.
CMTM1 (zeige CMTM1 Antikörper) and 3 are priority targets in glioblastomas. First insights into signalling of these two genes that might be conveyed by growth factor receptor (zeige RYK Antikörper), Src (zeige SRC Antikörper) family kinase and WNT (zeige WNT2 Antikörper) activation was presented.
Low expression of CMTM3 was associated with metastasis and recurrence of oral squamous cell carcinoma.
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified.
CKLF-like MARVEL transmembrane domain-containing protein 3
, chemokine-like factor super family 3
, CKLF-like MARVEL transmembrane domain containing 3
, chemokine-like factor superfamily member 3