anti-CD209 Molecule (CD209) Antikörper

CD209 encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. Zusätzlich bieten wir Ihnen CD209 Molecule Proteine (19) und CD209 Molecule Kits (10) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CD209 30835 Q9NNX6
CD209 170786 Q91ZX1
CD209 688951  
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Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert WB WB Suggested Anti-CD209 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  MCF7 cell lysate 100 μL 2 bis 3 Tage
Human Kaninchen Unkonjugiert WB Host:  Rabbit  Target Name:  CD209  Sample Type:  large intestine Tumor lysates  Antibody Dilution:  1.0ug/ml 100 μL 2 bis 3 Tage
Human Ratte Unkonjugiert FACS, IHC, IHC (p), IP Colon, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Heart, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) 100 μg 11 bis 14 Tage
Human Ziege Unkonjugiert ELISA, WB   100 μg 6 bis 7 Tage
Human Kaninchen Unkonjugiert FACS, ICC, IHC, IHC (fro), WB Western blot analysis of DC-SIGN using anti-DC-SIGN antibody .  Electrophoresis was performed on a 5-20% SDS-PAGE gel at 70V (Stacking gel) / 90V (Resolving gel) for 2-3 hours. The sample well of each  Lane was loaded with 50ug of sample under reducing conditions.   Lane 1: human Hela whole cell lysates, Lane 2: human MCF-7 whole cell lysates, Lane 3: human HepG2 whole cell lysates, Lane 4: human A549 whole cell lysates, Lane 5: rat spleen tissue lysates, Lane 6: mouse thymus tissue lysates.  After Electrophoresis, proteins were transferred to a Nitrocellulose membrane at 150mA for 50-90 minutes. Blocked the membrane with 5% Non-fat Milk/ TBS for 1.5 hour at RT. The membrane was incubated with rabbit anti-DC-SIGN antigen affinity purified polyclonal antibody (Catalog # ) at 0.5 µg/mL overnight at 4°C, then washed with TBS-0.1%Tween 3 times with 5 minutes each and probed with a goat anti-rabbit IgG-HRP secondary antibody at a dilution of 1:10000 for 1.5 hour at RT. The signal is developed using an Enhanced Chemiluminescent detection (ECL) kit (Catalog # EK1002) with Tanon 5200 system. A specific band was detected for DC-SIGN at approximately 46KD. The expected band size for DC-SIGN is at 46KD. IHC analysis of DC-SIGN using anti-DC-SIGN antibody . DC-SIGN was detected in paraffin-embedded section of human intestinal cancer tissue. Heat mediated antigen retrieval was performed in citrate buffer (pH6, epitope retrieval solution) for 20 mins. The tissue section was blocked with 10% goat serum. The tissue section was then incubated with 1µg/ml rabbit anti-DC-SIGN Antibody  overnight at 4°C. Biotinylated goat anti-rabbit IgG was used as secondary antibody and incubated for 30 minutes at 37°C. The tissue section was developed using Strepavidin-Biotin-Complex (SABC)(Catalog # SA1022) with DAB as the chromogen. 100 μg 4 bis 6 Tage
Human Kaninchen Unkonjugiert WB 100 μL 11 bis 14 Tage
Human Kaninchen Unkonjugiert IP, WB CD209 MaxPab rabbit polyclonal antibody. Western Blot analysis of CD209 expression in human liver. CD209 MaxPab rabbit polyclonal antibody. Western Blot analysis of CD209 expression in mouse liver. 100 μL 11 bis 12 Tage
Human Kaninchen Unkonjugiert ELISA, WB 100 μL Verfügbar
Human Kaninchen Unkonjugiert IHC, IHC (p), WB Human Tonsil (formalin-fixed, paraffin-embedded) stained with CD209 antibody ABIN214436 at 5 ug/ml followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Anti-CD209 / DC-SIGN antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml. 0.05 mg 11 bis 14 Tage
Human Maus FITC FACS Staining of CD209 transfected K562 cells with MOUSE ANTI HUMAN CD209: FITC (ABIN181973) 0.1 mg 6 bis 8 Tage

Am meisten referenzierte anti-CD209 Molecule Antikörper

  1. Human Monoclonal CD209 Primary Antibody für FACS - ABIN4898514 : Li, Xia, Liu, Wang, Dai, Wang, Zheng, Chen, Li, Abudumijiti, Zhou, Wang, Lu, Zhu, Yang, Zhang, Yin, Wang, Zhou, Lu, Zhou, Guo: Protective effects of astaxanthin on ConA-induced autoimmune hepatitis by the JNK/p-JNK pathway-mediated inhibition of autophagy and apoptosis. in PLoS ONE 2015 (PubMed)
    Show all 7 Pubmed References

  2. Human Monoclonal CD209 Primary Antibody für CyTOF, FACS - ABIN4900749 : Wu, Bashirova, Martin, Villamide, Mehlhop, Chertov, Unutmaz, Pope, Carrington, KewalRamani: Rhesus macaque dendritic cells efficiently transmit primate lentiviruses independently of DC-SIGN. in Proceedings of the National Academy of Sciences of the United States of America 2002 (PubMed)
    Show all 6 Pubmed References

  3. Human Monoclonal CD209 Primary Antibody für FACS - ABIN4898518 : Gautam, Carter, Katz, Butler, Barnes, Hasegawa, Ratterree, Silvestri, Marx, Hirsch, Pandrea, Apetrei: In vitro characterization of primary SIVsmm isolates belonging to different lineages. In vitro growth on rhesus macaque cells is not predictive for in vivo replication in rhesus macaques. in Virology 2007 (PubMed)
    Show all 5 Pubmed References

  4. Human Monoclonal CD209 Primary Antibody für ICC, FACS - ABIN786646 : Dakappagari, Maruyama, Renshaw, Tacken, Figdor, Torensma, Wild, Wu, Bowdish, Kretz-Rommel: Internalizing antibodies to the C-type lectins, L-SIGN and DC-SIGN, inhibit viral glycoprotein binding and deliver antigen to human dendritic cells for the induction of T cell responses. in Journal of immunology (Baltimore, Md. : 1950) 2005 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal CD209 Primary Antibody für FACS, IHC (p) - ABIN786650 : Berbic, Ng, Black, Markham, Russell, Basten, Fraser, Hey-Cunningham: A novel pilot study of endometrial stromal cells and immune cell populations in sentinel uterine-draining lymph nodes during the menstrual cycle and in endometriosis. in Reproductive sciences (Thousand Oaks, Calif.) 2013 (PubMed)
    Show all 5 Pubmed References

  6. Human Monoclonal CD209 Primary Antibody für FACS - ABIN786648 : Debeer, Le Luduec, Kaiserlian, Laurent, Nicolas, Dubois, Kanitakis: Comparative histology and immunohistochemistry of porcine versus human skin. in European journal of dermatology : EJD 2013 (PubMed)
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  7. Human Monoclonal CD209 Primary Antibody für ICC, IF - ABIN786647 : Rochereau, Verrier, Pin, Genin, Paul: Phenotypic localization of distinct DC subsets in mouse Peyer Patch. in Vaccine 2011 (PubMed)
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  8. Human Monoclonal CD209 Primary Antibody für - ABIN786649 : Soilleux: DC-SIGN (dendritic cell-specific ICAM-grabbing non-integrin) and DC-SIGN-related (DC-SIGNR): friend or foe? in Clinical science (London, England : 1979) 2003 (PubMed)
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  9. Human Polyclonal CD209 Primary Antibody für IHC (p), WB - ABIN541407 : Pöhlmann, Baribaud, Lee, Leslie, Sanchez, Hiebenthal-Millow, Münch, Kirchhoff, Doms: DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. in Journal of virology 2001 (PubMed)
    Show all 3 Pubmed References

  10. Human Polyclonal CD209 Primary Antibody für IHC (p), WB - ABIN541408 : Geijtenbeek, Torensma, van Vliet, van Duijnhoven, Adema, van Kooyk, Figdor: Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. in Cell 2000 (PubMed)
    Show all 3 Pubmed References

Weitere Antikörper gegen CD209 Molecule Interaktionspartner

Human CD209 Molecule (CD209) Interaktionspartner

  1. immature DCs and toll-like receptor 4 (TLR4) stimulated DCs had similar internalization capacity and were both able to cross-present antigen targeted via DC-SIGN. Interestingly, simultaneous triggering of TLR4 and DC-SIGN on DCs resulted in the translocation of cargo to the cytosol, leading to proteasome-dependent processing and increased CD8(+) T cell activation.

  2. In this study, we demonstrate that Yersinia pseudotuberculosis utilizes its lipopolysaccharide (LPS) core to interact with CD209 receptors, leading to invasion of human dendritic cells (DCs) and murine macrophages.

  3. DC-SIGN promoter single nucleotide polymorphisms correlated with risk of hepatitis C virus acquisition via sexual but not intravenous drug exposure, likely through modulation of mRNA expression levels.

  4. modulation of DC-SIGN and FcUpsilonR2A receptors expression on platelets in dengue

  5. These data indicate that VDR and DC-SIGN genetic variations are related to the susceptibility of oral paracoccidioidomycosis in the group of patients analysed.

  6. The findings demonstrate for the first time the direct involvement of the cell membrane DC-SIGN glycans in strengthening cell-pathogen interactions.

  7. DC-SIGN mediates TLR4-regulated NFkappaB activation but not activation of p38 and JNK.

  8. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions

  9. These findings indicate that DC-SIGN plays an important role in Japanese encephalitis virus transmission from dendritic cells to T cells and provide insight into how Japanese encephalitis virus exploits the migratory and antigen-presenting capabilities of dendritic cells to gain access to lymph nodes for dissemination and persistence in the host.

  10. this study shows that DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia

  11. The DC-SIGN -336G/A polymorphism significantly affects dengue hemorrhagic fever and dengue fever incidence with the effect more pronounced in certain analyzed patient subgroups (Meta-Analysis).

  12. The results suggest that DC-SIGN SNPs rs7252229, rs4804803, and rs735240 may influence nasopharyngeal carcinoma risk in the Chinese population.

  13. Polymorphism of CD209 and TLR3 genes in populations of North Eurasia

  14. searched for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Delta 32) with the human predisposition to development of various clinical presentations of tick-borne encephalitis

  15. These results show that DC-SIGN and TLR-4 interactions regulate inflammatory responses in renal tubular epithelial cells and participate in AKI pathogenesis.

  16. 1,25(OH)2D3 suppressed the DCSIGN expression in Mycobacterium tuberculosis infected onocytes/macrophages.

  17. Studied the association of CD209 promoter haplotypes with risk of HIV-1 infection in a cohort of Spanish male intravenous drug users (IDU) infected with hepatitis C virus (HCV).

  18. Upon gp120 binding to DC-SIGN, cellular NF-kappaB signaling was triggered, leading to the induction of matrix metalloproteinases, which subsequently degraded tight junction proteins and disrupted the blood-retinal barrier integrity.

  19. This study showed that N-glycans on the Gc and Gn surface glycoproteins redundantly support Rift Valley Fever Virus infection via DC-SIGN.

  20. Ligand-driven triggering of TLR-3, -4, NOD2, and DC-SIGN, despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells.

Cow (Bovine) CD209 Molecule (CD209) Interaktionspartner

  1. The development and use of CD209 to characterize the phenotype of CD209 expressing cells in bovine blood using flow cytometry is reported.

  2. a DC-SIGN-like molecule expressed specifically by bovine DC. This molecule may play an important role in the infection of bovine (DC) cells with M. bovis.

Rhesus Monkey CD209 Molecule (CD209) Interaktionspartner

  1. DC-SIGN+ cells showed a clear differential distribution in the decidua in the first 2 weeks of pregnancy, being found only adjacent to the implantation site

  2. DC-SIGN expression in mesenteric lymph nodes is significantly downregulated in simian immunodeficiency virus-infected pig-tailed macaques.

Pig (Porcine) CD209 Molecule (CD209) Interaktionspartner

  1. The cloning and characterization of the cDNA and gene encoding porcine DC-SIGN (pDC-SIGN)is reported. The results will help better understand the biological role(s) of DC-SIGN family in innate immunity during the evolutionary process.

Zebrafish CD209 Molecule (CD209) Interaktionspartner

  1. identification and functional characterization of DC-SIGN/CD209 molecule in zebrafish

Mouse (Murine) CD209 Molecule (CD209) Interaktionspartner

  1. mouse DC-SIGN shows partly overlapping similarities to human DC-SIGN; mDC-SIGN is expressed on GM-CSF cultured bone marrow-derived dendritic cells and macrophages

  2. CD209a drives severe Th17 cell-mediated immunopathology in a helminthic disease

  3. mDectin-1, mDectin-2, and SIGN-R1 are decorated by N-glycan structures that can be recognized by the carbohydrate recognition domain of Gal-3.

  4. M. scrofulaceum induces a semimature DC phenotype that is characterized by PD-L2 over-expression and elevated synthesis of IL-10, most likely through TLR4 and Raf-1 signaling pathway-dependent DC-SIGN stimulation.

  5. results suggested that podocytes in lupus nephritis can exert dendritic cell-like function through their expression of DC-SIGN, which may be involved in immune and inflammatory responses of renal tissues

  6. results indicate that SIGN-R1 and complement factors play an important role in the systemic clearance of radiation-induced apoptotic innate immune cells to maintain tissue homeostasis after gamma-irradiation

  7. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 to simultaneously bind both immune glycoproteins and microbial polysaccharide components.

  8. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics.

  9. Intestinal enterocytes regulate tissue-associated immune compartments under the control of DC-SIGN in inflammatory bowel disease.

  10. In vivo T cell activation induces the formation of CD209(+) PDL-2(+) dendritic cells.

  11. CD209a expression on dendritic cells is critical for the development of pathogenic Th17 cell responses in murine schistosomiasis.

  12. CD209a is activated in macrophages by LECT2.

  13. The neck region of the C-type lectin DC-SIGN regulates its surface spatiotemporal organization and virus-binding capacity on antigen-presenting cells

  14. interactions between the CRD of DC-SIGN and the extracellular matrix and/or cis interactions with transmembrane scaffolding protein(s) play an essential role in organizing these microdomains

  15. analysis of activated apoptotic cells induce dendritic cell maturation via engagement of Toll-like receptor 4 (TLR4), dendritic cell-specific intercellular adhesion molecule 3 (ICAM-3)-grabbing nonintegrin (DC-SIGN), and beta2 integrins

  16. Targeting DC-SIGN via its neck region leads to prolonged antigen residence in early endosomes, delayed lysosomal degradation, and cross-presentation.

  17. SIGN-R1 is critical in the regulation of immune responses.

  18. Data show that telmisartan reduced the mRNA expression of CD11c and TNF-alpha, M1 macrophage markers, and significantly increased the expressions of M2 markers, such as CD163, CD209.

  19. SIGN-R1 is expressed on a subset of macrophage receptor with a collagenous structure (MARCO-positive) macrophages. This subset is diminished when marginal zone (MZ) B cells are absent due to genetic developmental defects or B cell migration out of the MZ.

  20. Fully differentiated monocyte-derived DCs (Mo-DCs) develop in mice and DC-SIGN/CD209a marks the cells.

CD209 Molecule (CD209) Antigen-Profil

Protein Überblick

This gene encodes a transmembrane receptor and is often referred to as DC-SIGN because of its expression on the surface of dendritic cells and macrophages. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are rare but have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 10332\; often referred to as L-SIGN). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.

Genbezeichner und Symbole assoziert mit anti-CD209 Molecule (CD209) Antikörper

  • CD209 molecule (CD209) Antikörper
  • CD209 molecule (cd209) Antikörper
  • CD209a antigen (Cd209a) Antikörper
  • CD209 antigen-like protein D (LOC100529184) Antikörper
  • CD209c molecule (Cd209c) Antikörper
  • CD209 antigen (LOC100460708) Antikörper
  • CD209 antigen (LOC105484282) Antikörper
  • Cd209 Antikörper
  • CDSIGN Antikörper
  • CIRE Antikörper
  • CLEC4L Antikörper
  • CLEC4M Antikörper
  • DC-SIGN Antikörper
  • DC-SIGN1 Antikörper
  • Dcsign Antikörper
  • si:ch211-224h1.3 Antikörper
  • SIGN-R1 Antikörper
  • SIGNR5 Antikörper

Bezeichner auf Proteinebene für anti-CD209 Molecule (CD209) Antikörper

C-type lectin domain family 4 member L , C-type lectin domain family 4, member L , CD209 antigen , HIV gpl20-binding protein , dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin , CD209-like protein , DC-SIGN1 , dendritic cell-specific ICAM-3 grabbing non-integrin , C-type lectin domain family 4, member M , DC-SIGN protein , putative mannose-binding C-type lectin , CD209 antigen-like protein A , dendritic cell-specific ICAM-3-grabbing non-integrin , CD209 , CD209 antigen-like protein C , CD209c antigen , Dendritic cell-specific ICAM-3-grabbing non-integrin 1 , dendritic cell-specific ICAM-3 grabbing nonintegrin

30835 Homo sapiens
100136662 Oncorhynchus mykiss
450160 Pan troglodytes
485000 Canis lupus familiaris
513266 Bos taurus
574211 Macaca mulatta
100170134 Sus scrofa
100334918 Danio rerio
100462978 Felis catus
170786 Mus musculus
100529184 Oryzias latipes
688951 Rattus norvegicus
100460708 Pongo abelii
105484282 Macaca nemestrina
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