CD2 Molecule (CD2) ELISA Kits

Mouse (Murine) CD2 Molecule (CD2) Interaktionspartner

1. Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes

2. CD2 stimuli were mandatory for Treg cell survival with reduced Bim expression, but CD2 may not function as a direct receptor for molecules on stromal cells.

3. CD2 is important for the efficient development of CD4 single-positive thymocytes and TCR-dependent activation of mature CD4 lymph node T cells, but does not direct a particular helper T cell subset polarity.

4. This antigen is a dominant target for heart allograft responses.

5. molecular mechanism of heterophilic adhesion between the murine T-cell adhesion glycoprotein CD2 and its ligand CD48

6. Despite normal T cell numbers, mice deficient in the costimulatory molecules CD2 and CD28 spontaneously develop Pneumocystis carinii pneumonia.

7. autoimmunity may be mediated by a combination of genes in the SLAM/CD2 family cluster

8. Analysis of the ligand-receptor pairs involved in induction of germline transcripts (Igamma2a) necessary for switch recombination revealed that expression of CD48 on B cells and ligands CD2 and CD244 on NK cells are able to stimulate Igamma2a

9. CD2 deficient mice are more resistant to T. gondii infection than wild type mice

10. nanoscale increases in CD2-CD48-mediated intermembrane spacing decrease adhesion and reorganize the immunological synapse

11. CD244 inhibition and activation depends on CD2 and phospholipase C-gamma1

Human CD2 Molecule (CD2) Interaktionspartner

1. A new prognostic model for HR-/HER2+ breast cancer based on the expression of MMP11 and CD2 was developed and the distant metastasis-free survival for patients in the high-risk group according to our model was significantly lower than that for those in the low-risk group.

2. These results reveal an unexpected redundancy in the human NK cell response to human cytomegalovirus and suggest that CD2 provides "signal 2" in antibody-driven adaptive NK cell responses.

3. Establish CD2 as a new susceptibility factor for systemic sclerosis in a European Caucasian population.

4. the fundamental mechanism of glycosylation of human CD2 is to promote CD2-CD58 binding by conformational adjustment of CD2

5. CD58/CD2 is the primary costimulatory pathway in human CD28-CD8+ T cells.

6. Both the mRNA expression levels and protein expression levels of HSP27 were increased in astrocytes from POAG patients compared with those from normal control, suggesting that mutation in CD2 might pose a risk for POAG in Chinese population.

7. Although sMCs displayed immunoreactivity for one of the neoplastic antigens in the majority of SM patients, the aberrant CD2 and/or CD25 expression on sMCs is not as indicative of SM as the BMMC immunophenotype.

8. ERGdel may be a pure surrogate of CD2-positivity--which has been suggested to be a good prognositc marker in childhood ALL

9. Altogether, these results show that a high CD2 expression level is a hallmark of latently infected resting memory CD4(+) T cells in vivo.

10. Aberrant CD2 expression appears to further determine a shorter progression free survival

11. CD2-CD58/48 receptor-ligand interaction promotes and is required for nanotube formation in human natural killer cells.

12. CD2 expression does not contribute to improve the diagnosis of systemic mastocytosis when compared with aberrant CD25 expression alone.

13. CD2-mediated priming of resting natural killer (NK) cells is unaffected by their degree of functional maturation.

14. CD2 signals more strongly to S6-ribosomal protein, whereas CD28 costimulation specifically induces signaling necessary for proper NF-kappaB activation.

15. When isolated from multiple sclerosis patients, both nonmature and effector subsets of memory CD127(low) regulatory T cells exhibit kinetically distinct defects in suppression that are evident with CD2 pathway costimulation.

16. analysis of the importance of homotypic NK-to-NK cell cross-talk through 2B4/CD48 and CD2/CD58 pairs and further present their differential and overlapping roles in human NK cells

17. PTEN expression was up-regulated on RNA and protein level in freshly isolated human CD4(+) T cells following stimulation with CD28 or CD2.

18. molecules redistribute to the uropod during T cell scanning

19. Structural and functional studies of the extracellular domains of CD2 and CD58 and their complex. Review.

20. CD2BP2 is the ligand of the membrane-proximal proline-rich tandem repeat of CD2 in detergent-soluble membrane compartments, but is replaced by Fyn SH3 after CD2 is translocated into lipid rafts upon CD2 ectodomain clustering.

Pig (Porcine) CD2 Molecule (CD2) Interaktionspartner

1. CD2- gammadelta T cells showed CD2 de novo expression after ConA/IL-2/IL-12/IL-18 stimulation.

2. Porcine gamma-delta T lymphocytes can be categorized into two functionally and developmentally distinct subsets according to expression of CD2 and level of TCR.