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C1GALT1C1 encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans.
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elevated Tn levels in cancer and inflammation may be commonly regulated by the cytokine (TNFa (zeige TNF Antikörper) and IL6 (zeige IL6 Antikörper))-Cosmc signaling axis
The data suggest that hypermethylation of the Cosmc promoter may induce the expression of Tn antigen in activated T cells.
results provide new structure-function insight to Cosmc, indicate that Cosmc behaves as a modular protein and suggests points of modulation or regulation of in vivo chaperone function
Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1GALT1 (zeige C1GALT1 Antikörper)) and C1GALT1-specific chaperone 1 protein (C1GALT1C1) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells.
The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1 (zeige TGFB1 Antikörper). TGFbeta1 (zeige TGFB1 Antikörper) stimulation significantly decreased the mRNA levels of C1GalT1 (zeige C1GALT1 Antikörper) and Cosmc. TGFbeta1 (zeige TGFB1 Antikörper) may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 (zeige C1GALT1 Antikörper) and Cosmc.
mutations c.393T>A and c.72A>G in the exon region of Cosmc gene in children with Henoch-Schonlein purpura (HSP) are not associated with the onset of Henoch-Schonlein purpura
Data suggest that patients with IgA (zeige IgA Antikörper) nephropathy exhibit higher microRNA-374b in B cells compared to controls; microRNA-374b appears to target PTEN (phosphatase and tensin homolog) and Cosmc (C1GALT1 specific chaperone 1) proteins.
These results indicate that Tn antigens expression and T-synthase (zeige C1GALT1 Antikörper) inactivity in HT-29-Tn+ cells can be related to the absence of the Cosmc gene coding sequence in Cosmc active alleles
the impact of COSMC mediated Tn antigen expression in two human pancreatic ductal adenocarcinoma cell lines on cellular oncogenic properties, were investigated.
hypermethylation of Cosmc promoter region could be a key mechanism for the reduction of Cosmc mRNA expression in IgAN lymphocytes with associated increase in aberrantly glycosylated IgA1
Cosmc is an inflammatory bowel disease risk factor and is implicated in regulating the spatial pattern of dysbiosis and sex bias in IBD.
These results demonstrated that core 1-derived O-glycan is required for Tim4 (zeige TIMD4 Antikörper)-dependent normal efferocytosis and may contribute to the stable expression of the Tim4 (zeige TIMD4 Antikörper) glycoprotein.
Cosmc is an essential chaperone for correct protein O-glycosylation.
a somatic mutation in the chaperone gene Cosmc abolished function of a glycosyltransferase (zeige GTDC2 Antikörper), disrupting O-glycan Core 1 synthesis & creating a tumor-specific glycopeptidic neo-epitope consisting of a monosaccharide and a specific wild-type protein sequence
This gene encodes a type II transmembrane protein that is similar to the core 1 beta1,3-galactosyltransferase 1, which catalyzes the synthesis of the core-1 structure, also known as Thomsen-Friedenreich antigen, on O-linked glycans. This gene product lacks the galactosyltransferase activity itself, but instead acts as a molecular chaperone required for the folding, stability and full activity of the core 1 beta1,3-galactosyltransferase 1. Mutations in this gene have been associated with Tn syndrome. Alternatively spliced transcript variants encoding the same protein have been identified.
, core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 2
, C1GALT1-specific chaperone 1
, Core 1 beta3-galactosyltransferase-specific molecular chaperone
, C1GALT1-specific chaperone 1-like
, c1GALT1-specific chaperone 1-like
, C38H2-like protein 1
, beta 1,3-galactosyltransferase 2
, core 1 beta1,3-galactosyltransferase 2
, core 1 beta3-Gal-T2
, core 1 beta3-galactosyltransferase-specific molecular chaperone
, beta1,3-galactosyltransferase 2