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Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane.
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Piccolo (zeige PCLO ELISA Kits) puncta sandwiched Bassoon puncta and aligned in a Piccolo (zeige PCLO ELISA Kits)-Bassoon-Piccolo (zeige PCLO ELISA Kits) structure in adult neuromuscular junctions (NMJs). P/Q-type voltage-gated calcium channel (VGCC) puncta colocalized with Bassoon puncta. The P/Q-type VGCC and Bassoon protein levels decreased significantly in NMJs from aged mouse. In contrast, the Piccolo (zeige PCLO ELISA Kits) levels in NMJs from aged mice were comparable to levels in adult mice.
These data establish Bassoon as a major regulator of the molecular composition of the presynaptic neurotransmitter release sites.
Authors conclude that bassoon promotes vesicular replenishment and, consequently, a large standing pool of readily releasable synaptic vesicles at the endbulb synapse.
phosphorylation-induced 14-3-3 (zeige YWHAQ ELISA Kits) binding to Bassoon modulates its anchoring to the presynaptic cytomatrix
proper assembly of ribbon synapses depend on Bassoon
a novel role for Bassoon and Piccolo (zeige PCLO ELISA Kits) as critical regulators of presynaptic ubiquitination and proteostasis.
This studyy demonistrated that reduced bassoon expression or complete lack of full-length bassoon impaired sound encoding to a similar extent, which is consistent with the comparable reduction of the readily releasable vesicle pool
hippocampal overgrowth in Bassoon-mutant mice arises from a dysregulation of neurogenesis and apoptosis that might be associated with unbalanced BDNF (zeige BDNF ELISA Kits) levels.
Results support the notion that Bassoon is important for organizing the presynaptic active zone during the postnatal maturation of glutamatergic synapses.
Our findings reveal a novel function of Bassoon in the early formation and delivery of precursor spheres to nascent ribbon synaptic sites
D-amino acid oxidase (zeige DAO ELISA Kits) activity is inhibited by an interaction with bassoon protein at the presynaptic active zone.
Short-term synaptic depression is enhanced in Bassoon knockout mice, but synaptic transmission is unaffected.
Bassoon protein and the synaptic ribbon create a large number of release sites by organizing calcium channels and synaptic vesicles.
Loss of Bassoon in Bsn mutant mice causes a reduction in normal synaptic transmission, which can be attributed to the inactivation of a significant fraction of glutamatergic synapses.
The effect of BSN-MST1 (zeige MST1 ELISA Kits) locus on Crohn's disease predisposition was replicated, but no influence on ulcerative colitis or multiple sclerosis predisposition could be detected
This paper describes the structure of the mouse and rat Bsn genes, and characterizes the subcellular distribution of the Bassoon protein.
Neurotransmitters are released from a specific site in the axon terminal called the active zone, which is composed of synaptic vesicles and a meshwork of cytoskeleton underlying the plasma membrane. The protein encoded by this gene is thought to be a scaffolding protein involved in organizing the presynaptic cytoskeleton. The gene is expressed primarily in neurons in the brain. A similar gene product in rodents is concentrated in the active zone of axon terminals and tightly associated with cytoskeletal structures, and is essential for regulating neurotransmitter release from a subset of synapses.
presynaptic cytomatrix protein
, protein bassoon
, neuronal double zinc finger protein
, zinc finger protein 231
, bassoon (presynaptic cytomatrix protein)