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ARMCX3 encodes a member of the ALEX family of proteins which may play a role in tumor suppression.
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reduction of Alex3 correlates with the development of non-small cell lung cancer and predicts adverse clinical outcome of non-small cell lung cancer patients. The effect of Alex3 on inhibiting invasion and migration may attribute to upregulation of E-cadherin expression through AKT-Slug pathway inactivation.
The Wnt (zeige WNT2 ELISA Kits) pathway regulates mitochondrial distribution and dynamics through Alex3 protein degradation.
Sox10 (zeige SOX10 ELISA Kits) is a membrane-associated factor whose transcriptional function is increased by direct interactions with ARMCX3
This gene encodes a member of the ALEX family of proteins which may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and a single Armadillo (arm) repeat. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members on the X chromosome. Three transcript variants encoding the same protein have been identified for this gene.
, ARM protein lost in epithelial cancers on chromosome X 3
, arm protein lost in epithelial cancers, X chromosome, 3
, armadillo repeat-containing X-linked protein 3
, armadillo repeat containing, X-linked 3
, Armadillo repeat-containing X-linked protein 3
, armadillo repeat-containing X-linked protein 3-like
, armadillo repeat-containing X-linked protein 3-like protein