Annexin A2 Proteine (ANXA2)

ANXA2 encodes a member of the annexin family. Zusätzlich bieten wir Ihnen Annexin A2 Antikörper (240) und Annexin A2 Kits (58) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ANXA2 302 P07355
ANXA2 12306 P07356
ANXA2 56611 Q07936
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Top Annexin A2 Proteine auf

Showing 10 out of 37 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 10% SDS-PAGE stained with Coomassie Blue (CB), immunobloting with anti-6xHis (WB) serum and peptide fingerprinting by MALDI-TOF-TOF mass spectrometry 50 μg Anmelden zum Anzeigen 6 bis 9 Tage
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) Human Unkonjugiert   50 μg Anmelden zum Anzeigen 4 Days
Escherichia coli (E. coli) Human GST tag Annexin A2 (ANXA2) (AA 1-339), (full length) protein (GST tag) 1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Escherichia coli (E. coli) Human GST tag 50 μg Anmelden zum Anzeigen 11 Days
Escherichia coli (E. coli) Human Unkonjugiert SDS-PAGE analysis of Human Annexin A2 Protein. 100 μg Anmelden zum Anzeigen 11 bis 18 Tage
Hefe Schaf His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage

ANXA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, , ,
Mouse (Murine) ,

Rat (Rattus)

Am meisten referenzierte Annexin A2 Proteine

  1. Human Annexin A2 Protein expressed in Wheat germ - ABIN1345180 : Bhattacharjee, Ahamed, Pawlinski, Liu, Mackman, Ruf, Edgington: Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. in Circulation research 2008 (PubMed)
    Show all 2 Pubmed References

  2. Human Annexin A2 Protein expressed in Wheat germ - ABIN1345182 : Sun, Gao, Cai, Wang, Qu, He, Liu, Zhang, Lin, Ma, Yang, Qian, Zhao: Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma. in Carcinogenesis 2013 (PubMed)

  3. Human Annexin A2 Protein expressed in HEK-293 Cells - ABIN2714737 : Deng, Lei, Zhang, Zhang, Zheng, Zhang, Pan, Wang, Tian, Shen, Zhao, Lundberg, Liu, Papasian, Deng: Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans. in Molecular & cellular proteomics : MCP 2011 (PubMed)

Weitere Proteine zu Annexin A2 (ANXA2) Interaktionspartnern

Human Annexin A2 (ANXA2) Interaktionspartner

  1. High ANXA2 expression is associated with Liver Tumorigenesis.

  2. this work uncovers a new peptide motif that binds to and inhibits intracellular annexin A2 as a candidate therapeutic lead for potential translation into clinical applications

  3. Mechanistic studies revealed that FOXD2AS1 upregulated the expression of the miR206 target gene ANXA2 in hepatocellular carcinoma by acting as a miR206 sponge.

  4. study has localised AnxA2/S100A10 complexes to key anatomical locations in the placenta and suggests a role for this complex in amniotic epithelium, trophoblasts and syncytium, in addition to its well-known roles in endothelial cells

  5. Inhibition of ANXA2 will affect the expression of downstream targets and downstream signaling pathways, leading to the suppression of the malignant progression of tumors.

  6. our data suggest that overexpression of peroxiredoxin-2, annexin A2, and heat shock protein beta-1 was correlated with tumor invasion, metastasis, and poor prognosis, and therefore, these proteins may serve as potential diagnostic and therapeutic biomarkers.

  7. aptamer wh6 can block MM cell adhesion to ANXA2 and block the proliferation of MM cells induced by ANXA2

  8. The results demonstrated that ANX2 and stromal tenascin C regulated invasion in addition to stemness and anoikis resistance, which are crucial for metastasis in the progression of pancreatic ductal adenocarcinoma.

  9. Annexin A1 has a similar immunogenic expression and correlation with its analog Annexin A2 and their association may be a novel immune target of BD in Han Chinese population

  10. highly expressed in gastric cancer, related to tumor size, histological differentiation, lymph node metastasis

  11. models for annexin A2-mediated vesicle aggregation mechanisms.

  12. Our profiling data provided a rich source for further study of the molecular mechanisms of acquired drug resistance inneuroblastoma ( NB). Further study may determine the role of ANXA2 as a prognostic biomarker and a potential therapeutic target for patients with multidrug-resistant NB.

  13. These results suggested that increased ANXA2 and less expressed beta-catenin were correlated to adenomyosis-associated dysmenorrhea

  14. These data suggested that Annexin A2 induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 signaling, and provided an evidence that blockade of Annexin A2 could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs

  15. Results show that Anxa2-Tyr23 phosphorylation is necessary for proliferation, invasion, and metastasis of breast cancer cells in vitro and in vivo. Tyr23-phosphorylated Anxa2 binds to STAT3 and serves as a key regulator of STAT3 signaling.

  16. annexin A2 can potentially predict the development of pre-eclampsia. The low annexin A2 levels (<0.89 ng/ml) together with higher blood pressure and proteinuria constitute a higher risk to develop preeclampsia.

  17. Variants in the Annexin A2 (ANXA2) gene directly influence plasma LDL-C levels.

  18. this study showed that Annexin A2 inhibition suppresses proliferation and invasion in ovarian cancer via beta-catenin/EMT, proposing the potential role of Annexin A2 in the prevention and treatment of ovarian cancer

  19. FNDC3B and ANXA2 expression correlate negatively with patient survival in hepatocellular carcinoma

  20. UBAP2 formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, and then inhibited HCC progression.

Mouse (Murine) Annexin A2 (ANXA2) Interaktionspartner

  1. High ANXA2 expression is associated with Liver Tumorigenesis.

  2. PTGS2 deletion changes the natural distribution of ANXA2 in monocytes/macrophages, increasing TF expression and activity predisposing to venous thrombosis.

  3. Our data indicate that hepatic overexpression of ANX1 and ANX2 inhibits APAP-induced expansion of liver injury

  4. This study indicated that AnxA2 played complex roles in traversal of C. neoformans across host brain microvascular endothelial cells.

  5. contributes to pulmonary microvascular integrity by enabling vascular endothelial cadherin-related phosphatase activity, thereby preventing vascular leak during alveolar hypoxia

  6. our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 mRNA mediated by the SMN complex.

  7. Despite comparable fungal burden, Anxa2(-/-) mice died more rapidly than wild-type mice when infected with Cryptococcus neoformans, and Anxa2(-/-) mice exhibited enhanced inflammatory responses

  8. annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa.

  9. Our findings reveal a previously undemonstrated function for AnxA2 in inflammatory response in polymicrobial sepsis models

  10. Podxl-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2.

  11. The tick protein sialostatin L2 binds to annexin A2 and inhibits NLRC4-mediated inflammasome activation.

  12. Data show that annexin A2 (AnxA2) directly exerted negative regulation of inflammatory responses through Toll-like receptor 4 (TLR4)-initiated TRAM protein-TRIF protein pathway occurring on endosomes.

  13. the role of Axna2 is instructive for understanding the development of RA, suppress the effect of Axna2 might provide a new potential measure for treatment of RA.

  14. The role of ARF-6 and Annexin A2 in the invasion of mammalian cells by T. cruzi amastigotes.

  15. Taken together, these findings indicate for the first time that AnxA2 phosphorylation and actin remodeling evoked by oxidative stress depend on the sphingolipid pathway, via MMP2 and p38MAPK.

  16. Data indicate that annexin A2 (AnxA2) regulates the secretion of semaphorin 3D (Sema3D) from pancreatic ductal adenocarcinoma (PDA) cells.

  17. results suggest that legumain expression and activation and cleavage of annexin A2 are regulated by DJ-1 through p53

  18. AnxA2 regulates autophagy, thereby contributing to host immunity against bacteria through the Akt1-mTOR-ULK1/2 signaling pathway

  19. These data suggest that AnxA2 and AnxA5 can influence bone formation via regulation of osteoprogenitor proliferation, differentiation, and responsiveness to cytokines in addition to their well-studied function in matrix vesicles

  20. The tumor microenvironment interaction between ANXA2-CXCL12 is critical for metastatic phenotypes and may impact chemotherapeutic potential.

Cow (Bovine) Annexin A2 (ANXA2) Interaktionspartner

  1. ClfA binds with AnnexinA2 and this interaction could mediate S. aureus invasion into bovine mammary epithelial cells.

  2. AnxA2 functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR-SREBP-1c/Cyclin D1 signaling pathway.

  3. annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites.

  4. Annexins A1 and A2 are proteins produced by airway epithelial cells that may prevent inflammation in the healthy lung and be relevant to development of pneumonia in stressed cattle.

  5. Calves that later developed pneumonia had significantly lower levels of annexin A1 and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.

  6. Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer) trophectoderm may be related to the frequent failures of NT pregnancies.

  7. annexin II binds to CEACAM1 in a breast neoplasm model

  8. show for the first time that annexin A2 (AIIt) can undergo functional reactivation by glutaredoxin, therefore establishing that AIIt is regulated by reversible glutathionylation

  9. AII does not bind 1,25-D(3) in a physiologically relevant manner

  10. Data show that the mRNA-binding site of Annexin A2 resides in its domain IV.

  11. The results showed that alkaline phosphatase (ALP) activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake.

Pig (Porcine) Annexin A2 (ANXA2) Interaktionspartner

  1. ANXA2 can interact with vimentin and enhance porcine reproductive and respiratory syndrome virus (PRRSV) growth. This contributes to the regulation of PRRSV replication in infected cells and may have implications for the future antiviral strategies.

  2. In conclusion, Annexin 2 is the novel host protein identified to interact with classical swine fever virus E2 and promote virus multiplication.

  3. Amino acids R338, N359, G378 of NS5A were revealed to be pivotal for the ANXA2-NS5A interaction.

  4. Taken together, these results indicate that Nsp9 binding partner ANXA2 is beneficial for porcine reproductive and respiratory syndrome virus replication.

  5. Annexin A2 acts in exocytic apical membrane trafficking in small intestinal enterocytes and is proteolytically cleaved in situ by pancreatic proteinases once it has become externalized to the lumenal side of the brush border membrane. [annexin A2]

  6. An octameric model is proposed for the annexin A2/p11(S100A10) complex, which exerts annexin A2 function. The proposed structure of the annexin A2/p11 octamer sheds new light into annexin A2/p11 interaction.

Horse (Equine) Annexin A2 (ANXA2) Interaktionspartner

  1. ANXA2 and MMP1 might participate in remodeling during wound healing in the horse.

Annexin A2 (ANXA2) Protein Überblick

Protein Überblick

This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit Annexin A2 Proteine (ANXA2)

  • annexin A2 (ANXA2)
  • annexin A2 (Anxa2)
  • annexin A2 (anxa2)
  • annexin A2 S homeolog (anxa2.S)
  • anx2 Protein
  • anx2l4 Protein
  • anxa2 Protein
  • anxa2-a Protein
  • anxa2-b Protein
  • AW215814 Protein
  • cal1h Protein
  • lip2 Protein
  • lpc2 Protein
  • lpc2d Protein
  • MGC76145 Protein
  • p36 Protein
  • pap-i Protein
  • PAP-IV Protein

Bezeichner auf Proteinebene für Annexin A2 Proteine (ANXA2)

annexin II , annexin-2 , calpactin I heavy chain , calpactin I heavy polypeptide , calpactin-1 heavy chain , chromobindin 8 , chromobindin-8 , lipocortin II , placental anticoagulant protein IV , protein I , 33-kDa calcimedin , 33-kDa lymphocyte Ca<2+>- binding protein , 33kDa lymphocyte Ca<2+>- binding protein , 36-kDa calelectrin , PAP-IV , p36 , annexin A2 , Lipocortin II , annexin 2 , annexin A2-like , Annexin II type I , Annexin-2-A , Calpactin I heavy chain , Calpactin-1 heavy chain , annexin A2-A , annexin II type I , annexin-2-A

302 Homo sapiens
12306 Mus musculus
56611 Rattus norvegicus
282689 Bos taurus
394517 Xenopus (Silurana) tropicalis
396297 Gallus gallus
403435 Canis lupus familiaris
406192 Sus scrofa
706240 Macaca mulatta
747018 Pan troglodytes
100048993 Ovis aries
100054320 Equus caballus
100173821 Pongo abelii
100397902 Callithrix jacchus
100716883 Cavia porcellus
100357671 Oryctolagus cuniculus
397754 Xenopus laevis
101691698 Mustela putorius furo
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