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ANXA2 encodes a member of the annexin family. Zusätzlich bieten wir Ihnen Annexin A2 Antikörper (234) und Annexin A2 Kits (59) und viele weitere Produktgruppen zu diesem Protein an.
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Human Annexin A2 Protein expressed in Wheat germ - ABIN1345180
Bhattacharjee, Ahamed, Pawlinski, Liu, Mackman, Ruf, Edgington: Factor Xa binding to annexin 2 mediates signal transduction via protease-activated receptor 1. in Circulation research 2008
Show all 2 Pubmed References
Human Annexin A2 Protein expressed in Wheat germ - ABIN1345182
Sun, Gao, Cai, Wang, Qu, He, Liu, Zhang, Lin, Ma, Yang, Qian, Zhao: Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma. in Carcinogenesis 2013
Human Annexin A2 Protein expressed in HEK-293 Cells - ABIN2714737
Deng, Lei, Zhang, Zhang, Zheng, Zhang, Pan, Wang, Tian, Shen, Zhao, Lundberg, Liu, Papasian, Deng: Peripheral blood monocyte-expressed ANXA2 gene is involved in pathogenesis of osteoporosis in humans. in Molecular & cellular proteomics : MCP 2011
ANXA2 and MMP1 (zeige MMP1 Proteine) might participate in remodeling during wound healing in the horse.
AnxA2 functions as a critical regulator for amino acid or hormone-induced milk synthesis and mammary gland epithelial cell proliferation via the PI3K-mTOR (zeige FRAP1 Proteine)-SREBP-1c (zeige SREBF1 Proteine)/Cyclin D1 (zeige CCND1 Proteine) signaling pathway.
annexin A2-induced actin bundling is apparently essential for generating active exocytotic sites.
Calves that later developed pneumonia had significantly lower levels of annexin A1 (zeige ANXA1 Proteine) and annexin A2, which are potential biomarkers of increased susceptibility to pneumonia in recently weaned and transported feedlot cattle.
Because annexins I and II are abundant and have functions important to the maintenance of placentation, the down-regulation of the annexin genes in the cultured NT (nuclear transfer) trophectoderm may be related to the frequent failures of NT pregnancies.
annexin II binds to CEACAM1 (zeige CEACAM1 Proteine) in a breast neoplasm model
show for the first time that annexin A2 (AIIt) can undergo functional reactivation by glutaredoxin (zeige GRX1 Proteine), therefore establishing that AIIt is regulated by reversible glutathionylation
AII (zeige NLRP3 Proteine) does not bind 1,25-D(3) in a physiologically relevant manner
Data show that the mRNA-binding site of Annexin A2 resides in its domain IV.
The results showed that alkaline phosphatase (ALP) activity was significantly increased in matrix vesicles from calcified bovine vascular smooth muscle cells (BVSMCs) compared with noncalcified BVSMCs, as was annexin II and VI content and (45)Ca uptake.
models for annexin A2-mediated vesicle aggregation mechanisms.
Our profiling data provided a rich source for further study of the molecular mechanisms of acquired drug resistance inneuroblastoma ( NB). Further study may determine the role of ANXA2 as a prognostic biomarker and a potential therapeutic target for patients with multidrug-resistant NB.
These results suggested that increased ANXA2 and less expressed beta-catenin (zeige CTNNB1 Proteine) were correlated to adenomyosis-associated dysmenorrhea
These data suggested that Annexin A2 induces cisplatin resistance of non-small cell lung cancer (NSCLC)via regulation of JNK/c-Jun/p53 (zeige TP53 Proteine) signaling, and provided an evidence that blockade of Annexin A2 could serve as a novel therapeutic approach for overcoming drug resistance in NSCLCs
Results show that Anxa2-Tyr23 phosphorylation is necessary for proliferation, invasion, and metastasis of breast cancer cells in vitro and in vivo. Tyr23-phosphorylated Anxa2 binds to STAT3 (zeige STAT3 Proteine) and serves as a key regulator of STAT3 (zeige STAT3 Proteine) signaling.
annexin A2 can potentially predict the development of pre-eclampsia. The low annexin A2 levels (<0.89 ng/ml) together with higher blood pressure and proteinuria constitute a higher risk to develop preeclampsia.
Variants in the Annexin A2 (ANXA2) gene directly influence plasma LDL-C levels.
this study showed that Annexin A2 inhibition suppresses proliferation and invasion in ovarian cancer via beta-catenin (zeige CTNNB1 Proteine)/EMT (zeige ITK Proteine), proposing the potential role of Annexin A2 in the prevention and treatment of ovarian cancer
FNDC3B and ANXA2 expression correlate negatively with patient survival in hepatocellular carcinoma
UBAP2 formed a complex with Annexin A2 and promoted the degradation of Annexin A2 protein by ubiquitination, and then inhibited HCC (zeige FAM126A Proteine) progression.
In conclusion, Annexin 2 is the novel host protein identified to interact with classical swine fever virus E2 and promote virus multiplication.
Amino acids R338, N359, G378 of NS5A were revealed to be pivotal for the ANXA2-NS5A interaction.
Taken together, these results indicate that Nsp9 binding partner ANXA2 is beneficial for porcine reproductive and respiratory syndrome virus replication.
Annexin A2 acts in exocytic apical membrane trafficking in small intestinal enterocytes and is proteolytically cleaved in situ by pancreatic proteinases once it has become externalized to the lumenal side of the brush border membrane. [annexin A2]
An octameric model is proposed for the annexin A2/p11(S100A10 (zeige S100A10 Proteine)) complex, which exerts annexin A2 function. The proposed structure of the annexin A2/p11 (zeige S100A10 Proteine) octamer sheds new light into annexin A2/p11 (zeige S100A10 Proteine) interaction.
PTGS2 (zeige PTGS2 Proteine) deletion changes the natural distribution of ANXA2 in monocytes/macrophages, increasing TF expression and activity predisposing to venous thrombosis.
Our data indicate that hepatic overexpression of ANX1 (zeige ANXA1 Proteine) and ANX2 inhibits APAP-induced expansion of liver injury
This study indicated that AnxA2 played complex roles in traversal of C. neoformans across host brain microvascular endothelial cells.
contributes to pulmonary microvascular integrity by enabling vascular endothelial cadherin (zeige CDH5 Proteine)-related phosphatase activity, thereby preventing vascular leak during alveolar hypoxia
our studies show that this G-motif represents a novel and essential determinant for axonal localization of the Anxa2 mRNA mediated by the SMN (zeige STMN1 Proteine) complex.
Despite comparable fungal burden, Anxa2(-/-) mice died more rapidly than wild-type mice when infected with Cryptococcus neoformans, and Anxa2(-/-) mice exhibited enhanced inflammatory responses
annexin A2 contributes to lung injury and fibrotic disease by mediating the fibrogenic actions of FXa (zeige F10 Proteine).
Our findings reveal a previously undemonstrated function for AnxA2 in inflammatory response in polymicrobial sepsis models
Podxl (zeige PODXL Proteine)-overexpression in neural stem/progenitor cells leads to an up-regulation of Annexin A2.
The tick protein sialostatin L2 binds to annexin A2 and inhibits NLRC4 (zeige NLRC4 Proteine)-mediated inflammasome activation.
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions as an autocrine factor which heightens osteoclast formation and bone resorption. This gene has three pseudogenes located on chromosomes 4, 9 and 10, respectively. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
, annexin II
, Lipocortin II
, annexin A2-like
, calpactin I heavy chain
, calpactin-1 heavy chain
, lipocortin II
, placental anticoagulant protein IV
, protein I
, calpactin I heavy polypeptide
, chromobindin 8
, annexin 2
, 33-kDa calcimedin
, 33-kDa lymphocyte Ca<2+>- binding protein
, 33kDa lymphocyte Ca<2+>- binding protein
, 36-kDa calelectrin