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This locus represents naturally occurring read-through transcription between the neighboring GPR75 (G protein-coupled receptor 75) and ASB3 (ankyrin repeat and SOCS box containing 3) on chromosome 2. Zusätzlich bieten wir Ihnen ASB3 Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.
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ASB3 dysfunction resulted from gene mutations or down-regulated expression frequently exists in colorectal cancer and likely plays a key role in the pathogenesis and progression of colorectal cancer.
GWAS findings for bronchodilator response in asthmatic subjects suggest that ASB3 gene, associated with smooth muscle relaxation, may play a role in the genetics of asthma.
ASB3 is a negative regulator of TNF-R2 (zeige TNFRSF1B Proteine)-mediated cellular responses to TNF-alpha (zeige TNF Proteine) by direct targeting of TNF-R2 (zeige TNFRSF1B Proteine) for ubiquitination and proteasome-mediated degradation.
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Alternatively spliced transcript variants have been described for this gene.
ankyrin repeat and SOCS box protein 3
, ankyrin repeat and SOCS box-containing protein 3
, ankyrin repeat-containing SOCS box protein 3
, ankyrin repeat and SOCS box-containing 3-like
, ankyrin repeat and SOCS box-containing 3