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The protein encoded by ASB4 is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. Zusätzlich bieten wir Ihnen ASB4 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Based on its differential expression, neuroanatomical distribution and colocalisation, we hypothesise that rat Asb-4 is a gene involved in energy homeostasis.
Expression of imprinted gene Asb4 was unregulated in haploid androgenetic/gynogenetic blastocysts.
In functional endothelial co-culture assays, JAR (zeige MYO6 Antikörper) cells ectopically expressing ASB4 increased endothelial cell turnover and stabilized endothelial tube formation, both of which are hallmarks of vascular differentiation within the placenta.
The interaction of Asb-4 with IRS4 (zeige IRS4 Antikörper) in cell lines mediates the degradation of IRS4 (zeige IRS4 Antikörper) and decreases insulin (zeige INS Antikörper) signaling.
Tumor necrosis factor alpha (zeige TNF Antikörper) upregulates ankyrin repeat and suppressor of cytokine signalling (zeige SOCS1 Antikörper) box protein 4 expression.
Asb-4 is a key regulatory protein in the central nervous system, involved in the control of feeding behavior and metabolic rate.
Asb4 has been identified as an imprinted gene by high-throughput screening using RIKEN cDNA microarray.
The present study demonstrates that Asb-4 interacts with GPS1 (zeige GPS1 Antikörper) and inhibits JNK (zeige MAPK8 Antikörper) activity.
These results suggest that ASB-4 plays pivotal roles in mammalian testis development and spermatogenesis.
The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants have been described for this gene but some of the full length sequences are not known.
ankyrin repeat and SOCS box protein 4
, ankyrin repeat and SOCS box-containing protein 4
, ankyrin repeat and SOCS box-containing 4