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The protein encoded by ANG is an exceedingly potent mediator of new blood vessel formation. Zusätzlich bieten wir Ihnen Angiogenin Kits (99) und Angiogenin Proteine (38) und viele weitere Produktgruppen zu diesem Protein an.
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Data show that phospholipase D2 (PLD2 (zeige PLD2 Antikörper))-produced phosphatidic acid (PA) promoted cell invasion through the the expression of angiogenin (ANG) in clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC) cells.
The results revealed that PCNA (zeige PCNA Antikörper) is predominantly localized in the cytoplasm, while hAng is distributed both in the nucleus and in the cytoplasm. hAng and PCNA (zeige PCNA Antikörper) colocalize in the cytoplasm, suggesting that they may interact in this compartment.
RNase 5 suppressed p27 (zeige PAK2 Antikörper) and up-regulated cyclin D1 (zeige CCND1 Antikörper), D3, and E by activating PI3-kinase (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) in CECs to initiate cell cycle progression
When yeast genetic interaction partners held in common between human OPTN (zeige OPTN Antikörper) and ANG were validated in mammalian cells and zebrafish, MAP2K5 (zeige MAP2K5 Antikörper) kinase emerged as a potential drug target for amyotrophic lateral sclerosis therapy
There was a significant association between RNase 5 and histological differentiation in colon adenocarcinomas, but no association between RNase 5 and Necl 4 (zeige CADM4 Antikörper) in gastric or colon adenocarcinomas
Results continue to establish ANG as an oncoprotein and further reveal that ANG contributes to oncogenesis by the activation of MMP2 (zeige MMP2 Antikörper) through modulation of DNMT3b (zeige DNMT3B Antikörper) functions.
(31) RRR (zeige RRS1 Antikörper)(33) and (50) KRSIK(54) motifs of angiogenin might play a critical role in the regulation of p53 (zeige TP53 Antikörper)-mediated apoptosis and angiogenesis in cancer cells.
Study shows that plexin-B2 (PLXNB2 (zeige PLXNB2 Antikörper)) is the functional receptor for ANG in endothelial, cancer, neuronal, and normal hematopoietic and leukemic stem and progenitor cells.
Delivery of the therapeutic human genes VEGF (zeige VEGFA Antikörper) and ANG using an adenoviral vector improved functional recovery after traumatic spinal cord injury in a rat model. Immunofluorescent analysis of the post-treatment spinal cord suggested that the positive effect of Ad5 (zeige PSEN2 Antikörper)-VEGF (zeige VEGFA Antikörper)+Ad5 (zeige PSEN2 Antikörper)-ANG transduction on recovery of locomotor function may be due to the action of glial cells on motor neurons.
Ang down-regulate the expression of Col (zeige HDAC1 Antikörper)-I, alpha-SMA (zeige SMN1 Antikörper) and TGF-beta1 (zeige TGFB1 Antikörper)/Smad2 (zeige SMAD2 Antikörper)/3 and subsequently inhibits fibroblast-myofibroblast transition.
Association analyses revealed the significant associations (P < 0.05) between the porcine ANG g. 149G>T polymorphism and mean corpuscular volume (MCV), mean corpuscular hemoglobin (zeige HBB Antikörper) (MCH (zeige PMCH Antikörper)), mean platelet volume (MPV) and platelet-large cell ratio (P-LCR).
ANG plays a non-cell-autonomous role in regulation of hematopoiesis by simultaneously preserving hematopoietic stem/progenitor cells stemness and promoting myeloid-restricted progenitor cell proliferation.
angiogenin and ILK (zeige ILK Antikörper) signaling pathway plays a pivotal role in mediating the inhibitory effects of RI on melanoma cells growth
Our data provide new insights into the paracrine activities of angiogenin in the nervous system, and further highlight the critical role of non-neuronal cells in the pathogenesis of Amyotrophic lateral sclerosis
RNase 4 (zeige RNASE4 Antikörper) and RNase 5/ang 1 (zeige ANGPT1 Antikörper) are unique among the RNase A (zeige RNASE1 Antikörper) ribonuclease genes in that they maintain a complex gene locus that is conserved across species with transcription initiated from tissue-specific dual promoters followed by differential exon splicing.
ANG plays an important role in neurite pathfinding and this has implications for amyotrophic lateral sclerosis.
Angiogenin mRNA was expressed in murine skin in a hair-cycle dependent manner, with maximum levels observed at the late anagen.
All three types of the ANG inhibitor suppress rRNA transcription of the prostate luminal epithelial cells and inhibit AKT (zeige AKT1 Antikörper)-induced PIN (zeige DYNLL1 Antikörper), indicating an essential role of ANG in AKT (zeige AKT1 Antikörper)-mediated cell proliferation and survival.
Murine angiogenin mRNA and protein are upregulated in motoneurons in response to hypoxia, and that Hypoxia-Inducible Factor 1 (zeige HIF1A Antikörper) is sufficient and required to upregulate angiogenin expression during hypoxia.
This study is the first to demonstrate that hypoxia upregulates Ang1 (zeige ANGPT1 Antikörper) expression via HIF2alpha (zeige EPAS1 Antikörper)-mediated transcriptional activation in pericytes, which plays a key role in angiogenesis.
rAAV-mediated angiogenin gene transfer induces angiogenesis and modifies left ventricular remodeling in rats with myocardial infafrction.
bovine angiogenin is the substance mainly responsible for the inhibitory effect of bovine milk on osteoclast-mediated bone resorption
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region.
, epididymis luminal protein 168
, ribonuclease 5
, angiogenin, ribonuclease A family, member 1
, angiogenin ribonuclease 1