AlkB, Alkylation Repair Homolog 5 (E. Coli) Proteine (ALKBH5)

Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).. Zusätzlich bieten wir Ihnen ALKBH5 Antikörper (33) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte ALKBH5 ALKBH5 303193  
ALKBH5 54890 Q6P6C2
ALKBH5 268420 Q3TSG4
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Top ALKBH5 Proteine auf antikoerper-online.de

Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$338.33
Details
Hefe Xenopus laevis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,982.83
Details

ALKBH5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu AlkB, Alkylation Repair Homolog 5 (E. Coli) (ALKBH5) Interaktionspartnern

Human AlkB, Alkylation Repair Homolog 5 (E. Coli) (ALKBH5) Interaktionspartner

  1. N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A (zeige GPM6A Proteine)-recognising proteins, including FTO (zeige FTO Proteine) and ALKBH5.

  2. ALKBH5 knockdown in breast cancer cells significantly decreased metastasis from breast to lungs in immunodeficient mice

  3. ALKBH5-FOXM1 (zeige FOXM1 Proteine) pathway is critical for glioblastoma proliferation and tumorigenesis.ALKBH5 expression increases in glioblastoma stem-like cells and predicts poor survival in glioblastoma patients.

  4. HIF-dependent ALKBH5 expression mediates enrichment of BCSCs in the hypoxic tumor microenvironment

  5. The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population.

  6. Structures of human ALKBH5 demethylase (zeige MBD2 Proteine) reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.

  7. Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms.

  8. findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB (zeige ALKBH Proteine) members

  9. ALKBH5 is a RNA demethylase (zeige MBD2 Proteine) and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells.

  10. ALKBH5 may have a role in the regulation of cellular responses to hypoxia as a class of HIF-transcriptional target gene

Mouse (Murine) AlkB, Alkylation Repair Homolog 5 (E. Coli) (ALKBH5) Interaktionspartner

  1. This study identified reversible m6A (zeige GPM6A Proteine) modification as a critical mechanism of posttranscriptional control of mRNA fate in late meiotic and haploid spermatogenic cells.

ALKBH5 Protein Überblick

Protein Überblick

Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).

Genbezeichner und Symbole assoziert mit ALKBH5

  • alkB homolog 5, RNA demethylase (Alkbh5)
  • alkB homolog 5, RNA demethylase L homeolog (alkbh5.L)
  • alkB homolog 5, RNA demethylase (ALKBH5)
  • Abh5 Protein
  • AW050020 Protein
  • AW215868 Protein
  • E130207K11 Protein
  • Ofoxd Protein
  • OFOXD1 Protein
  • RGD1309496 Protein

Bezeichner auf Proteinebene für ALKBH5

RNA demethylase ALKBH5 , alkylated DNA repair protein alkB homolog 5 , alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 , probable alpha-ketoglutarate-dependent dioxygenase ABH5 , oxoglutarate and iron-dependent oxygenase domain containing

GENE ID SPEZIES
303193 Rattus norvegicus
444130 Xenopus laevis
54890 Homo sapiens
268420 Mus musculus
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