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Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).. Zusätzlich bieten wir Ihnen ALKBH5 Antikörper (34) und viele weitere Produktgruppen zu diesem Protein an.
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Overexpression of ALKBH5 in MIA-PaCa-2 and BxPC-3 cells, demonstrats that ALKBH5 could inhibit cell migration and invasion and ALKBH5 inhibits cell motility by demethylating and increasing expression of KCNK15- AS1.
N(6)-Methyladenosine itself serves as a 'conformational marker', which induces different conformational outcomes in RNAs depending on sequence context. This critically impacts its interactions with several m6A (zeige GPM6A Proteine)-recognising proteins, including FTO (zeige FTO Proteine) and ALKBH5.
ALKBH5 knockdown in breast cancer cells significantly decreased metastasis from breast to lungs in immunodeficient mice
ALKBH5-FOXM1 (zeige FOXM1 Proteine) pathway is critical for glioblastoma proliferation and tumorigenesis.ALKBH5 expression increases in glioblastoma stem-like cells and predicts poor survival in glioblastoma patients.
HIF-dependent ALKBH5 expression mediates enrichment of BCSCs in the hypoxic tumor microenvironment
The ALKBH5 gene may play a role in conferring risk of MDD in the Chinese population.
Structures of human ALKBH5 demethylase (zeige MBD2 Proteine) reveal a unique binding mode for specific single-stranded N6-methyladenosine RNA demethylation.
Modelling substrate into the active site of ALKBH5 reveals conserved residues important for recognition and demethylation mechanisms.
findings provide a structural basis for understanding the substrate recognition specificity of Alkbh5 and offer a foundation for selective drug design against AlkB (zeige ALKBH Proteine) members
ALKBH5 is a RNA demethylase (zeige MBD2 Proteine) and its action strongly suggests that the reversible methyladenosine modification has fundamental and broad functions in mammalian cells.
This study identified reversible m6A (zeige GPM6A Proteine) modification as a critical mechanism of posttranscriptional control of mRNA fate in late meiotic and haploid spermatogenic cells.
Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron (By similarity).
RNA demethylase ALKBH5
, alkylated DNA repair protein alkB homolog 5
, alpha-ketoglutarate-dependent dioxygenase alkB homolog 5
, probable alpha-ketoglutarate-dependent dioxygenase ABH5
, oxoglutarate and iron-dependent oxygenase domain containing