anti-ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Antikörper

Human ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Interaktionspartner

1. These results suggest that Pgp and endogenous TNF-alpha positively regulate cancer cell malignancy and contribute to changes in normal cell behavior through membrane microparticles.

2. An independent effect was not evident for MDR1 C3435T polymorphism.

3. ATP binding cassette subfamily B member 1 (ABCB1) 2677G>T is suggested to be an important determinant of warfarin dosage.

4. Results found that MDR1 expression level is downregulated in FK866-resistant HCT116 colorectal cancer cell line and provide evidence that ABCB1 plays a key role in CRC drug resistance to NAMPT inhibitor FK866.

5. In both extravillous trophoblast and cytotrophoblast explant differentiation experiments, silencing of ABCB1 leads to induction of the fusion markers human hCG, ERVW-1 and GJA1 and terminal differentiation of both trophoblast subtypes.

6. Together with previous data, these findings lead to a general model of substrate and inhibitor coupling to P-glycoprotein.

7. We performed the first population PK-PD study assessing the influence of ABCB1 gene polymorphisms and the expression of this gene on the thromboprophylactic therapy with rivaroxaban in patients undergoing knee or hip replacement surgery. We observed a decrease in ABCB1 expression after the orthopedic surgery and demonstrated a positive correlation between the ABCB1 gene expression and the rivaroxaban CL/F.

8. The donor and recipient CYP3A5*3 polymorphism influences tacrolimus pharmacokinetics in the first month post-transplantation, whereas the association with recipient ABCB1 3435 C > T is inconclusive.

9. high expression of MDR1 can affect the efflux ability to Methotrexate (MTX) by up-regulating the expression of P-gp, thus enhancing the drug resistance to MTX in rheumatoid arthritis fibroblast-like synoviocytes

10. Genotypes of the rs1202184 locus of the MDR1 gene are associated with refractory epilepsy in children, for which the AA genotype plays a dominant role.

11. Results indicate that elevated ABCB1 expression induced by C-terminal truncation of HBx was responsible for doxorubicin resistance in HCC.

12. The results reveal the potential regulatory mechanism of FTH1P3 on breast cancer paclitaxel resistance through miR-206/ABCB1 axis.

13. Crown ethers reverse P-glycoprotein-mediated multidrug resistance in cancer cells.

14. High MDR1 expression is associated with acute lymphoblastic leukemia.

15. The study demonstrated that the simultaneous presence of TMDR1, A CYP2D6*4 and A NAT2*7 alleles robustly increased the risk of developing ulcerative colitis by 3.49-fold. The current study suggests that CYP2D6*4 and MDR1 3435 C/T gene polymorphisms may be risk factors for UC susceptibility.

16. HIF1A-induced MDR1 and MRP4 promote Th17 responses in Crohn's disease.

17. In conclusion, we provide evidence that P-gp may be involved in an AhR-dependent detoxification process induced in response to the uremic toxin IS.

18. sofosbuvir GS-331007 metabolite plasma levels were affected by variants in the ABCB1 and HNFalpha genes

19. The contribution of polymorphisms in ABCB1 to drug pharmacokinetics.

20. FENDRR attenuates NSCLC cell stemness through inhibiting the HuR/MDR1 axis

Mouse (Murine) ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Interaktionspartner

1. ABCB1 is involved in neo-absorbed vitamin D efflux by the enterocytes and that it also contributes to vitamin D transintestinal excretion and likely impacts vitamin D status.

2. esults suggest that P-gp plays important role in mediating rivastigmine non-cholinergic beneficial effects, including Abeta brain load reduction, neuroprotective and anti-inflammatory effects in the AD mouse models.

3. this study shows that MDR1 deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation

4. A panel of 18 P-gp substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp can affect the pulmonary kinetics of a subset of P-gp substrates.

5. Data suggest that the overexpression of P-gp in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.

6. We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.

7. Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp, multi-drug resistance protein, MDR1).Drugs with ER < 1 almost do not bind the main binding cavity (MBC) of P-gp.

8. conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.

9. Mdr1 enforces T Cell homeostasis in the presence of intestinal bile acids.

10. Loss of ABCB1 expression is associated with neonatal hyperbilirubinemia.

11. the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp ATPase activity

12. Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.

13. Chrysosplenetin inhibited P-gp activity and reverse the up-regulated P-gp and MDR1 levels induced by artemisinin.

14. Tamsulosin and tolterodine with P-gp gene expression and activity in an enantiomer-specific way.

15. Pgp-coupled ATPase activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.

16. Data show that human transgenic mutant huntingtin (mHtt) aggregation might be regulated by multidrug resistance protein 1 (MDR1) which suggests that MDR1 might be a potential therapeutic target for Huntington's disease.

17. In vitro and in vivo downregulation of the ATP binding cassette transporter B1 by the HMG-CoA reductase inhibitor simvastatin

18. Efficient chemoprotection of CDD and MDR1 transduced hematopoietic 32D as well as primary lin(-) cells was proven in the context of Ara-C and anthracycline application

19. Mdr1b participates in the elimination of paraquat from the kidneys and protects against subsequent toxicity.

20. These study data have facilitated understanding of the molecular mechanisms of neurotoxicosis in ABCB1-1Delta mutant mice following exposure to various P-gp substrates.