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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ABCB1B Primary Antibody für FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
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MDR1 (zeige TBC1D9 Antikörper) is not expressed on erythrocyte membrane.
The genetic polymorphisms of the multi-drug resistance-1 (MDR-1 (zeige TBC1D9 Antikörper)) and human cytochrome P450 (zeige CYP Antikörper) 3A (CYP3A4 (zeige CYP3A4 Antikörper) and CYP3A5 (zeige CYP3A5 Antikörper)) genes were analyzed and compared between steroid sensitive, steroid resistant and control groups.
This meta-analysis suggests that the MDR1 (zeige TBC1D9 Antikörper) C > T polymorphism was not associated with the risk of MM. To confirm these findings, further comprehensive and well-designed studies are needed.
High MDR1 (zeige TBC1D9 Antikörper) expression is associated with chemoresistance in ovarian cancer.
13-cis (zeige CISH Antikörper)-retinoic acid, retinol and retinyl-acetate inhibited the Pgp (zeige PGPEP1 Antikörper) and ABCG2 mediated substrate transport as well as the substrate stimulated ATPase (zeige DNAH8 Antikörper) activity of these transporters.
Haplotype analysis of ABCB1 (zeige ABCB1 Antikörper) conducted in patients with bullous pemphigoid (zeige DST Antikörper) demonstrated that the 1236T-2677G-3435T haplotype may protect against development of disease.
High ABCB1 (zeige ABCB1 Antikörper) expression is associated with Bendamustine-resistance in Mantle Cell Lymphoma.
Data show that multidrug resistance gene 1 (MDR1 (zeige TBC1D9 Antikörper)) expression was associated with worsen survival of esophageal squamous cell carcinoma (ESCC) patients with cisplatin-based chemotherapy.
ABCB1 (zeige ABCB1 Antikörper) variation affected myelosuppression, progression-free survival and overall survival in ovarian cancer patients who were treated with paclitaxel and carboplatin
Our data showed that the expression of the MDR1 (zeige TBC1D9 Antikörper) gene was significantly higher in malignant tissue than in the normal tissues of patients with STS (zeige STS Antikörper). In addition, high MDR1 (zeige TBC1D9 Antikörper) expression was significantly associated with local advances, as well as poor response to treatment.
this study shows that MDR1 (zeige ABCB4 Antikörper) deficiency impairs mitochondrial homeostasis and promotes intestinal inflammation
A panel of 18 P-gp (zeige ABCB4 Antikörper) substrates were administered into the airways of an isolated perfused mouse lung (IPML) model derived from Mdr1a (zeige ABCB4 Antikörper)/Mdr1b knockout mice. Parallel intestinal absorption studies were performed. Lung P-gp (zeige ABCB4 Antikörper) can affect the pulmonary kinetics of a subset of P-gp (zeige ABCB4 Antikörper) substrates.
Data suggest that the overexpression of P-gp (zeige ABCB4 Antikörper) in neoplastic cells may be associated with alterations in O-glycosylated cell surface proteins, including mucins, and this alteration may be responsible for the reduced cell sensitivity to the O-glycosylation inhibitor GalNAc-alpha-O-benzyl.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Antikörper), multi-drug resistance protein, MDR1 (zeige ABCB4 Antikörper)).Drugs with ER < 1 (zeige MIER1 Antikörper) almost do not bind the main binding cavity (MBC (zeige CACNA1C Antikörper)) of P-gp (zeige ABCB4 Antikörper).
conclusion, MDR1 (zeige ABCB4 Antikörper) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Antikörper)-II layer.
Mdr1 (zeige ABCB4 Antikörper) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (zeige ABCB1 Antikörper) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (zeige ABCB4 Antikörper) ATPase (zeige DNAH8 Antikörper) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1