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The membrane-associated protein encoded by ABCB1B is a member of the superfamily of ATP-binding cassette (ABC) transporters. Zusätzlich bieten wir Ihnen ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ABCB1B Primary Antibody für FACS, IF (p) - ABIN670161
Hu, Peng, Li: The expression and significance of P-glycoprotein, lung resistance protein and multidrug resistance-associated protein in gastric cancer. in Journal of experimental & clinical cancer research : CR 2009
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Promoter methylation was found to be an important mechanism in gene regulation of ABCB1 (zeige ABCB1 Antikörper) in parental cancer cell lines and their drug-resistant sublines.
This study provides evidence for three alcohol-induced ONFH susceptibility genes (NOS3 (zeige NANOS3 Antikörper), ABCB1 (zeige ABCB1 Antikörper) and IL23R (zeige IL23R Antikörper)) in Chinese males and polymorphisms of them may be associated with alcohol-induced ONFH risk.
Contribution of tumor endothelial cells to drug resistance: anti-angiogenic tyrosine kinase (zeige TXK Antikörper) inhibitors act as p-glycoprotein antagonists.
Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin by inhibiting energy metabolism which may suppress P-gp (zeige ABCB4 Antikörper) function.
Results imply that LHBs, in association with HIF-1alpha (zeige HIF1A Antikörper), induces MDR1 (zeige TBC1D9 Antikörper) overexpression, which may contribute to the pathogenic changes in chronic hepatitis B infection.
endothelin-A receptor (zeige EDNRA Antikörper)-activated ABCB1 (zeige ABCB1 Antikörper) expression has a role in nintedanib resistance in FGFR1 (zeige FGFR1 Antikörper)-driven small cell lung cancer
Review/Meta-analysis: CRISPR-Cas9 system is a useful tool for the modification of ABCB1 (zeige ABCB1 Antikörper) gene and reversing multi-drug resistance in osteosarcoma cells.
ABCB1 (zeige ABCB1 Antikörper) expression represents the primary (sometimes exclusive) resistance mechanism in neuroblastoma (zeige ARHGEF16 Antikörper) cells with acquired resistance to SNS (zeige SCN10A Antikörper)-032.
Histone deacetylase (zeige HDAC1 Antikörper) inhibitors induce P-gp (zeige ABCB4 Antikörper) expression in colorectal cancer in two distinct ways: transcriptional activation and mRNA stabilization
Ectopic expression of ABCB1 (zeige ABCB1 Antikörper) promoted the miR (zeige MLXIP Antikörper)-595-overexpressing HO8910PM and SKOV-3 cell proliferation, colony formation and invasion.
We conclude that mdr1b and bcrp are essential to ovarian protection from chemotoxicity and may have an important physiological role in the ovary.
Molecular Dynamics simulations and docking of drugs performed for P-gp (P-gp (zeige ABCB4 Antikörper), multi-drug resistance protein, MDR1 (zeige ABCB4 Antikörper)).Drugs with ER < 1 (zeige MIER1 Antikörper) almost do not bind the main binding cavity (MBC (zeige CACNA1C Antikörper)) of P-gp (zeige ABCB4 Antikörper).
conclusion, MDR1 (zeige ABCB4 Antikörper) and BCRP are expressed on apical membranes of the rodent placental SynT (zeige STX1A Antikörper)-II layer.
Mdr1 (zeige ABCB4 Antikörper) enforces T Cell homeostasis in the presence of intestinal bile acids.
Loss of ABCB1 (zeige ABCB1 Antikörper) expression is associated with neonatal hyperbilirubinemia.
the high-affinity site of P-glycoprotein is inaccessible because of either a conformational change or binding of detergent at the binding site in a detergent micelle environment; ligands bind to a low-affinity site, resulting in altered modulation of P-gp (zeige ABCB4 Antikörper) ATPase (zeige DNAH8 Antikörper) activity
Data suggest that ATP binding to Abcb1b/P-glycoprotein (Pgp) in liposomes exhibits cooperativity with verapamil (a cardiovascular/antiarrhythmia drug); cooperativity between verapamil and a nonhydrolyzable ATP analog (AMPPNP) leads to distinct global conformational changes in Abcb1b/Pgp.
Chrysosplenetin inhibited P-gp (zeige ABCB4 Antikörper) activity and reverse the up-regulated P-gp (zeige ABCB4 Antikörper) and MDR1 (zeige ABCB4 Antikörper) levels induced by artemisinin.
Tamsulosin and tolterodine with P-gp (zeige ABCB4 Antikörper) gene expression and activity in an enantiomer-specific way.
Pgp (zeige ABCB4 Antikörper)-coupled ATPase (zeige DNAH8 Antikörper) activity kinetics measured with a range of verapamil and digoxin concentrations fit well to a DDI model encompassing non-competitive and competitive inhibition of digoxin by verapamil.
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier.
, colchicin sensitivity
, doxorubicin resistance
, multidrug resistance protein 1
, ATP-binding cassette sub-family B member 1
, P glycoprotein 1
, multidrug resistance protein 1B
, ATP-binding cassette sub-family B (MDR/TAP) member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1 (P-glycoprotein/multidrug resistance 1)
, ATP-binding cassette, sub-family B (MDR/TAP), member 1B
, ATP-binding cassette, subfamily B, member 1B
, P-glycoprotein/multidrug resistance 1