anti-Topoisomerase II alpha (TOP2A) Antikörper

Bezeichnung:
anti-Topoisomerase (DNA) II alpha 170kDa Antikörper (TOP2A)
Auf www.antikoerper-online.de finden Sie aktuell 267 Topoisomerase (DNA) II alpha 170kDa (TOP2A) Antikörper von 22 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Topoisomerase II alpha Kits (23) und Topoisomerase II alpha Proteine (3) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 295 Topoisomerase II alpha Produkte verfügbar.
Synonyme:
D230016L12Rik, TOP-2, TOP2, TOP2A, TP2A

Meistgesuchte Reaktivitäten zu anti-Topoisomerase II alpha (TOP2A) Antikörper

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anti-Mouse (Murine) Topoisomerase II alpha Antikörper:

anti-Rat (Rattus) Topoisomerase II alpha Antikörper:

anti-Human Topoisomerase II alpha Antikörper:

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Am meisten referenzierte anti-Topoisomerase II alpha Antikörper

  1. Human Monoclonal Topoisomerase II alpha Primary Antibody für WB - ABIN1109282 : Yoshida, Yamaguchi, Shinagawa, Taira, Nakayama, Miki: Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage. in Molecular and cellular biology 2006 (PubMed)
    Zeige alle 8 Referenzen für 1109282

  2. Human Monoclonal Topoisomerase II alpha Primary Antibody für IHC (p), IP - ABIN1109281 : Kaplan, Greenlund, Tanner, Shaw, Schreiber: Identification of an interferon-gamma receptor alpha chain sequence required for JAK-1 binding. in The Journal of biological chemistry 1996 (PubMed)
    Zeige alle 7 Referenzen für 1109281

  3. Human Polyclonal Topoisomerase II alpha Primary Antibody für EIA, WB - ABIN955291 : Vranic, Frkovic-Grazio, Lamovec, Serdarevic, Gurjeva, Palazzo, Bilalovic, Lee, Gatalica: Adenoid cystic carcinomas of the breast have low Topo IIα expression but frequently overexpress EGFR protein without EGFR gene amplification. in Human pathology 2010 (PubMed)
    Zeige alle 5 Referenzen für 955291

  4. Human Polyclonal Topoisomerase II alpha Primary Antibody für ELISA, WB - ABIN1533131 : Lang, Mirski, Cummings, Yu, Gerlach, Cole: Structural organization of the human TOP2A and TOP2B genes. in Gene 1998 (PubMed)

  5. Human Polyclonal Topoisomerase II alpha Primary Antibody für EIA, IF - ABIN955290 : Kawamura, Pope, Christensen, Sun, Terekhova, Boege, Mielke, Andersen, Marko: Mitotic chromosomes are constrained by topoisomerase II-sensitive DNA entanglements. in The Journal of cell biology 2010 (PubMed)

Weitere Antikörper gegen Topoisomerase II alpha Interaktionspartner

Mouse (Murine) Topoisomerase (DNA) II alpha 170kDa (TOP2A) Interaktionspartner

  1. Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (zeige TOP2 Antikörper)-targeting agents.

  2. We demonstrated that Nup98 (zeige NUP98 Antikörper)-TopIIbeta and Nup98 (zeige NUP98 Antikörper)-SETBP1 (zeige SETBP1 Antikörper) negatively regulate the XPO1 (zeige XPO1 Antikörper)-mediated protein export. Our results will contribute to the understanding of the molecular mechanism by which the Nup98 (zeige NUP98 Antikörper)-fusion proteins induce tumorigenesis.

  3. TOP2 (zeige TOP2 Antikörper) and BAF (zeige BANF1 Antikörper) cooperate to recruit pluripotency factors, which explains some of the instructive roles of BAF (zeige BANF1 Antikörper) complexes.

  4. Deletion or deficiency of PTEN (zeige PTEN Antikörper) leads to down regulation of TOP2A, dysfunction of the decatenation checkpoint and incomplete DNA decatenation in G2 and M phases.

  5. Inhibition of DNA topoisomerase II (zeige TOP2 Antikörper) selectively reduces the threat of tumorigenicity

  6. Cohesin removal is a prerequisite for the posterior topoisomerase IIalpha-mediated resolution of persisting catenations between segregating chromatids during anaphase II.

  7. Data show that unfolded protein response (UPR)-induced changes in topoisomerase IIalpha (Topo IIalpha) protein levels are not responsible for resistance to etoposide, and that the PERK plays a Topo IIalpha-independent role in altered sensitivity to the drug.

  8. TOP2beta (zeige TOP2B Antikörper) as a factor involved in regulating granulosa cell genomic integrity and follicle atresia.

  9. Topoisomerase IIa not only contributes to stem-cell transcriptome regulation but also primes developmental genes for subsequent activation upon differentiation.

  10. studies indicate that the ability of TOP2A to prevent DNA entanglement at mitosis requires BAF (zeige BANF1 Antikörper) complexes and suggest that this activity contributes to the role of BAF (zeige BANF1 Antikörper) subunits as tumour suppressors

Human Topoisomerase (DNA) II alpha 170kDa (TOP2A) Interaktionspartner

  1. Tumors with higher topoisomerase IIalpha and/or mitosin (zeige CENPF Antikörper) expression have a higher risk of recurrence after initial treatment, and these patients may benefit from adjuvant treatment and closer radiological follow-up

  2. Both the genome instability and cell death of MRE11 (zeige MRE11A Antikörper)-null and MRE11 (zeige MRE11A Antikörper)-mutated H129N cells are significantly reversed by overexpression of Tdp2 (zeige TDP2 Antikörper), an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 (zeige MRE11A Antikörper) nuclease (zeige DCLRE1C Antikörper) activity is likely to remove the DNA lesions.

  3. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (zeige TCF4 Antikörper) and interacts with Wnt (zeige WNT2 Antikörper) response elements (WREs) and promoters of direct target genes of TCF (zeige HNF4A Antikörper) transcription, including: MYC (zeige MYC Antikörper), vimentin (zeige VIM Antikörper), AXIN2 (zeige AXIN2 Antikörper) and LEF1 (zeige LEF1 Antikörper)

  4. This study shows that both survivin (zeige BIRC5 Antikörper) and TIIalpha are independent prognostic predictors in human grade II/III astrocytomas stratified for IDH1 (zeige IDH1 Antikörper)-mutation status

  5. Polyamide functionalisation at the N1-position offers a design strategy to improve drug-like properties. Dicationic HxIP* 3 increased topo IIalpha expression and chemosensitivity to topo II (zeige TOP2 Antikörper)-targeting agents.

  6. BD ProExtrade mark C assay containing MCM2 (zeige MCM2 Antikörper) and TOP2A antibodies showed strong specific nuclear staining that correlated with increased cervical dysplasia and lesion severity.

  7. Fbxo28 (zeige FBXO28 Antikörper) regulates topoisomerase IIalpha decatenation activity and plays an important role in maintaining genomic stability.

  8. TOP2A rs471692 was not associated with chemoradiotherapy response, whereas tumor regression, weight loss, clinical stage, and cigarette smoking were independent prognostic predictors for these Chinese patients with non-small cell lung cancer.

  9. we propose that phosphorylation of TOP2A by CDC7 (zeige CDC7 Antikörper)/DBF4 (zeige DBF4 Antikörper) in early S-phase prevents its localization and/or activity at centromeres, and inhibition of TOP2A function could be relevant to prevent premature separation of centromeric DNA.

  10. Data indicate that cortex involvement, lower World Health Organization grade and DNA topoisomerase II (zeige TOP2 Antikörper) positivity were strong predictors for preoperative epileptic seizures.

Topoisomerase II alpha (TOP2A) Antigen-Profil

Beschreibung des Gens

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Alternative names and synonyms associated with Topoisomerase II alpha (TOP2A)

  • DNA topoisomerase II, alpha isozyme (TOP2A) Antikörper
  • DNA topoisomerase II, alpha isozyme (Bm1_08705) Antikörper
  • topoisomerase (DNA) II alpha (Top2a) Antikörper
  • topoisomerase (DNA) II alpha 170kDa (TOP2A) Antikörper
  • topoisomerase (DNA) II beta (Top2b) Antikörper
  • topoisomersae II (TOPOII) Antikörper
  • D230016L12Rik Antikörper
  • TOP-2 Antikörper
  • TOP2 Antikörper
  • TOP2A Antikörper
  • TP2A Antikörper

Bezeichner auf Proteinebene für TOP2A

DNA topoisomerase II, alpha isozyme , DNA Topoisomerase II alpha , DNA topoisomerase 2-alpha , topoisomerase (DNA) 2 alpha , DNA gyrase , DNA topoisomerase (ATP-hydrolyzing) , DNA topoisomerase II, 170 kD , DNA topoisomeraseII_alpha , DNA topoisomerase 2-beta , DNA topoisomerase II, beta isozyme

GENE ID SPEZIES
700707 Macaca mulatta
6096668 Brugia malayi
21973 Mus musculus
360243 Rattus norvegicus
100689304 Cricetulus griseus
7153 Homo sapiens
480525 Canis lupus familiaris
395570 Gallus gallus
787696 Bos taurus
21974 Mus musculus
396917 Sus scrofa
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