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SMAD2 Proteine (SMAD2)

SMAD, Mothers Against DPP Homolog 2 Proteine (SMAD2)
Auf finden Sie aktuell 28 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD2 Antikörper (408) und SMAD2 Kits (40) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 496 SMAD2 Produkte verfügbar.
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
alle Proteine anzeigen Gen GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

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Am meisten referenzierte SMAD2 Proteine

  1. Human SMAD2 Protein expressed in Escherichia coli (E. coli) - ABIN667736 : Bonni, Wang, Causing, Kavsak, Stroschein, Luo, Wrana: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. in Nature cell biology 2001 (PubMed)
    Zeige alle 2 Referenzen für ABIN667736

  2. Human SMAD2 Protein expressed in HEK-293 Cells - ABIN2732219 : Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016 (PubMed)

Weitere Proteine zu SMAD2 Interaktionspartnern

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. The results of this study found that Bptf and TGF-beta (zeige TGFB1 Proteine)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Proteine) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (zeige EOMES Proteine) a (Eomesa (zeige EOMES Proteine)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Proteine) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. The nuclear importin (zeige KPNA4 Proteine) IPO5 (zeige IPO5 Proteine) was identified as a novel interacting protein of SMAD1 (zeige GARS Proteine). Overexpression of IPO5 (zeige IPO5 Proteine) in various cell lines specifically increases nuclear localization of BMP receptor (zeige BMPR1A Proteine)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (zeige IPO5 Proteine) and BMP but not TGF-beta (zeige TGFB1 Proteine) R-SMADs.

  2. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (zeige TGFB1 Proteine)/Smad2 signaling pathway, but not Smad1 (zeige GARS Proteine)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  3. the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 (zeige SMAD7 Proteine) promoter-mediated activation of TGF-beta (zeige TGFB1 Proteine)/Smad2 signaling

  4. A significant association was found between the low expression of inhibitory protein SMAD-7 (zeige SMAD7 Proteine) and both zeta-chain-associated protein kinase (zeige CDK7 Proteine) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (zeige GARS Proteine)/8 and lower SMAD-4 (zeige SMAD4 Proteine) expression in chronic lymphocytic leukemia cells

  5. High expression of SMAD2 is associated with colorectal carcinoma.

  6. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

  7. overexpression of miR29b markedly reduced the expression levels of COL1A1 (zeige COL1A1 Proteine) and alphaSMA (zeige ACTA2 Proteine), and decreased the expression and nuclear accumulation of pSmad2/3.

  8. p-SMAD2/3 proteins were remarkably increased in bladder carcinoma. High p-SMAD2/3 was not statistically associated with clinicopathological characteristics of the patients. Overexpression of hepaCAM (zeige HEPACAM Proteine) prevented the p-SMAD2/3 translocation from the cytoplasm to the nucleus in bladder cancer cells. The p-SMAD2/3 pathway is critical for hepaCAM (zeige HEPACAM Proteine)-induced cancer cell apoptosis.

  9. silencing NLRC5 reduced extracellular matrix expression in keloid fibroblasts through inhibiting the TGF-beta1 (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling pathway.

  10. Data indicate the TGF-beta (zeige TGFB1 Proteine) pathway regulates the epithelial-to-mesenchymal transition (EMT (zeige ITK Proteine)) of gastric cancer cells by increasing the levels of microRNA miRNA-181b to target Timp3 (zeige TIMP3 Proteine) via the Smad2/3/4-dependent pathway.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. E2a (zeige TCF3 Proteine) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  2. GDF11 (zeige GDF11 Proteine) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  3. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. In conclusion, TGF-beta (zeige TGFB1 Proteine) signaling pathway may influence liver fibrosis by incorporating with YB-1 (zeige YBX1 Proteine), indicating that YB-1 (zeige YBX1 Proteine) could be a potential target for therapies against liver fibrosis.

  2. miR (zeige MLXIP Proteine)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (zeige TGFB1 Proteine) receptor 1 and SMAD2.

  3. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (zeige IHH Proteine) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  4. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (zeige TGFB1 Proteine).

  5. Data show that muscle-specific (zeige EIF3K Proteine) Smad (zeige SMAD1 Proteine) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  6. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (zeige WNT2 Proteine) pathway, and inhibition of Smad2/3 signaling and Shh (zeige SHH Proteine) pathways.

  7. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  8. Smad2 and Smad3 (zeige SMAD3 Proteine) oppositely modify STAT3 (zeige STAT3 Proteine)-induced transcription of IL-17A (zeige IL17A Proteine) and retinoic acid receptor (zeige RARA Proteine)-related orphan nuclear receptor (zeige NR1D1 Proteine), RORgammat encoded by Rorc (zeige RORC Proteine), by acting as a co-activator and co-repressor of STAT3 (zeige STAT3 Proteine), respectively.

  9. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

  10. pSmad3L-Ser (zeige SIGLEC1 Proteine) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (zeige TRH Proteine) immunostaining-positive cells are cancer stem cells.

SMAD2 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2)
  • SMAD family member 2 (smad2)
  • MAD homolog 2 (Drosophila) (smad2)
  • SMAD family member 2 (Smad2)
  • 7120426M23Rik Protein
  • fj43c06 Protein
  • hMAD-2 Protein
  • hSMAD2 Protein
  • JV18 Protein
  • JV18-1 Protein
  • Madh2 Protein
  • Madr2 Protein
  • mMad2 Protein
  • Smad-2 Protein
  • wu:fj43c06 Protein
  • Xmad2 Protein
  • XSmad2 Protein

Bezeichner auf Proteinebene für SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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