Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human SMAD2 Protein expressed in HEK-293 Cells - ABIN2732219
Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016
The non-Smad (zeige SMAD1 Proteine) JNK (zeige MAPK8 Proteine) signaling pathway, which is downstream of Nodal signaling, regulates nuclear movement independently of the Smad (zeige SMAD1 Proteine) pathway, and this nuclear movement is associated with Smad (zeige SMAD1 Proteine) signal transduction toward the nucleus.
The results of this study found that Bptf and TGF-beta (zeige TGFB1 Proteine)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Proteine) expression and hence neural posteriorization.
Smad2 and Eomesodermin (zeige EOMES Proteine) a (Eomesa (zeige EOMES Proteine)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Proteine) forms a general component of the Smad2 signalling complex in zebrafish.
These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.
study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription
Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.
Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis
CRT (zeige SLC6A8 Proteine) regulates TGF-beta1 (zeige TGFB1 Proteine)-induced-EMT (zeige ITK Proteine) through modulating Smad (zeige SMAD1 Proteine) signaling
P311 (zeige C5orf13 Proteine) is a novel TGFbeta1 (zeige TGFB1 Proteine)/Smad (zeige SMAD1 Proteine) signaling-mediated regulator of transdifferentiation in epidermal stem cells during cutaneous wound healing.
human epidermal growth factor receptor (zeige EGFR Proteine) 2 (HER-2 (zeige ERBB2 Proteine)) levels, were correlated well with TSP50 (zeige PRSS50 Proteine)/p-Samd2 (zeige SARM1 Proteine)/3 and TSP50 (zeige PRSS50 Proteine)/p27 (zeige PAK2 Proteine) expression status. Thus, our studies revealed a novel regulatory mechanism underlying TSP50 (zeige PRSS50 Proteine)-induced cell proliferation and provided a new favorable intervention target for the treatment of breast cancer
IL-17 can induce A549 alveolar epithelial cells to undergo epithelial-mesenchymal transition via the TGF-beta1 mediated Smad2/3 and ERK1/2 activation
a critical role for miR (zeige MLXIP Proteine)-503-3p in induction of breast cancer EMT (zeige ITK Proteine)
Nuclear localization of Smad2 was reduced in TGFbeta (zeige TGFB1 Proteine)-1-stimulated primary tubular epithelial cells. Changes in nuclear Smad2 correlated with a reduced expression of the pro-fibrotic factor CTGF (zeige CTGF Proteine). Transient downregulation of Smad2 interfered with TGFbeta (zeige TGFB1 Proteine)-1-induced CTGF (zeige CTGF Proteine) synthesis.
Low SMAD2 expression is associated with progression of hepatic fibrosis.
In order to study the translation between mouse model and patients, we evaluated the signature of phosphorylated Sma- and Mad-related protein 2 (pSmad2), as molecular marker of TGF-beta/activin activity, in the kidneys of streptozotocin (STZ)-treated mice compared to that of type 1 diabetes (T1D) patients.
SMAD2/SMAD3 (zeige SMAD3 Proteine) signaling by bone morphogenetic proteins causes disproportionate induction of HAS2 (zeige HAS2 Proteine) expression and hyaluronan production in immortalized human granulosa cells.
miR (zeige MLXIP Proteine)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (zeige TGFB1 Proteine)-induced cell cycle arrest. These results suggest that miR (zeige MLXIP Proteine)-27a may function as an oncogene (zeige RAB1A Proteine) by regulating SMAD2 and SMAD4 (zeige SMAD4 Proteine) in lung cancer.
Grg4 occupancy at the Xnr1 (zeige NODAL Proteine) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (zeige FOXH1 Proteine) at the Xnr1 (zeige NODAL Proteine) enhancer, an essential feature of the transcriptional switch mechanism.
E2a (zeige TCF3 Proteine) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis
GDF11 (zeige GDF11 Proteine) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.
XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.
Activin A (zeige INHBA Proteine) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (zeige NANOG Proteine) and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Proteine)/OCT4 (zeige POU5F1 Proteine) expression.
the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis
Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.
a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
Data (including data from studies using knockout mice) suggest Garp/Lrrc32 (zeige LRRC32 Proteine) is involved in up-regulation of Tgfb3 (zeige TGFB3 Proteine) and is essential for embryogenesis of palate; Garp (zeige LRRC32 Proteine) knockout causes postnatal lethality, cleft palate, and decreased apoptosis and Smad2 phosphorylation in medial edge epithelial cells of palatal shelf of embryos. (Garp (zeige LRRC32 Proteine) = glycoprotein A repetitions predominant (zeige LRRC32 Proteine) protein; Tgfb3 (zeige TGFB3 Proteine) = transforming growth factor beta 3 (zeige TGFB3 Proteine))
This study tested the hypothesis that inhibins act in an autocrine manner on Leydig cells using a pre-pubertal Leydig cell line, TM3 (zeige TPM1 Proteine), as a model of immature Leydig cells.
Lnc-LFAR1 binds directly to Smad2/3 and promotes transcription of TGFbeta (zeige TGFB1 Proteine), Smad2, Smad3 (zeige SMAD3 Proteine), Notch2 (zeige NOTCH2 Proteine) and Notch3 (zeige NOTCH3 Proteine) which, in turn, results in TGFbeta (zeige TGFB1 Proteine) and Notch (zeige NOTCH1 Proteine) pathway activation.
the levels of Smad2/3, P-Smad2/3 expressions were decreased, while the level of Smad7 (zeige SMAD7 Proteine) expression was increased after treatment with osthole.
These findings implicate TGF-beta (zeige TGFB1 Proteine)-Smad2/3 signaling in activated tissue-resident cardiac fibroblasts as principal mediators of the fibrotic response.
selective inhibition of SMAD3 (zeige SMAD3 Proteine) or CCT6A (zeige CCT6A Proteine) efficiently suppresses TGF-beta (zeige TGFB1 Proteine)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 Proteine) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 Proteine) for non-small-cell lung carcinoma.
results demonstrate that TGF-beta1 (zeige TGFB1 Proteine)-induced autophagy links beta-catenin (zeige CTNNB1 Proteine) and Smad (zeige SMAD1 Proteine) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (zeige CTNNB1 Proteine)/p-Smad2/ILK (zeige ILK Proteine) pathway.
These results suggest that Nedd9 (zeige NEDD9 Proteine) is a Smad2/3 target gene implicated in RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis.
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.
SMAD, mothers against DPP homolog 2
, MAD (mothers against decapentaplegic, Drosophila) homolog 2
, SMA- and MAD-related protein 2
, SMAD 2
, SMAD family member 2
, mothers against DPP homolog 2
, mothers against decapentaplegic homolog 2
, MAD homolog 2
, Sma- and Mad-related protein 2
, mother against DPP homolog 2
, mothers against decapentaplegic-like 2
, Smad 2
, mad-related protein 2