SMAD2 Proteine (SMAD2)

Bezeichnung:
SMAD, Mothers Against DPP Homolog 2 Proteine (SMAD2)
Auf www.antikoerper-online.de finden Sie aktuell 29 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Proteine von 13 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD2 Antikörper (424) und SMAD2 Kits (43) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 516 SMAD2 Produkte verfügbar.
Synonyme:
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2
alle Proteine anzeigen Gen GeneID UniProt
SMAD2 4087 Q15796
SMAD2 17126 Q62432
SMAD2 29357 O70436

Weitere Synonyme anzeigen

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Am meisten referenzierte SMAD2 Proteine

  1. Human SMAD2 Protein expressed in Escherichia coli (E. coli) - ABIN667736 : Bonni, Wang, Causing, Kavsak, Stroschein, Luo, Wrana: TGF-beta induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. in Nature cell biology 2001 (PubMed)
    Zeige alle 2 Referenzen für 667736

  2. Human SMAD2 Protein expressed in HEK-293 Cells - ABIN2732219 : Atanelishvili, Shirai, Akter, Buckner, Noguchi, Silver, Bogatkevich: M10, a caspase cleavage product of the hepatocyte growth factor receptor, interacts with Smad2 and demonstrates antifibrotic properties in vitro and in vivo. in Translational research : the journal of laboratory and clinical medicine 2016 (PubMed)

Weitere Proteine zu SMAD2 Interaktionspartnern

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. The results of this study found that Bptf and TGF-beta (zeige TGFB1 Proteine)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Proteine) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (zeige EOMES Proteine) a (Eomesa (zeige EOMES Proteine)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Proteine) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. miR (zeige MLXIP Proteine)-27a contributed to cell proliferation and invasion by inhibiting TGF-beta (zeige TGFB1 Proteine)-induced cell cycle arrest. These results suggest that miR (zeige MLXIP Proteine)-27a may function as an oncogene (zeige RAB1A Proteine) by regulating SMAD2 and SMAD4 (zeige SMAD4 Proteine) in lung cancer.

  2. cPLA2alpha (zeige PLA2G4A Proteine) activates PI3K (zeige PIK3CA Proteine)/AKT (zeige AKT1 Proteine) and inhibits Smad2/3 during epithelial-mesenchymal transition of hepatocellular carcinoma cells.

  3. selective inhibition of SMAD3 (zeige SMAD3 Proteine) or CCT6A (zeige CCT6A Proteine) efficiently suppresses TGF-beta (zeige TGFB1 Proteine)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 Proteine) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 Proteine) for non-small-cell lung carcinoma.

  4. In response to TGF-beta (zeige TGFB1 Proteine), RASSF1A (zeige RASSF1 Proteine) is recruited to TGF-beta (zeige TGFB1 Proteine) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (zeige MUL1 Proteine) ITCH. RASSF1A (zeige RASSF1 Proteine) degradation is necessary to permit Hippo pathway effector YAP1 (zeige YAP1 Proteine) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.

  5. Smad2 is a key scaffold, allowing RIN1 (zeige RIN1 Proteine) to act as a GTP (zeige AK3 Proteine) exchange factor for MFN2 (zeige MFN2 Proteine)-GTPase (zeige RACGAP1 Proteine) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  6. Ang (zeige ANG Proteine) down-regulate the expression of Col (zeige HDAC1 Proteine)-I, alpha-SMA (zeige SMN1 Proteine) and TGF-beta1 (zeige TGFB1 Proteine)/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

  7. The nuclear importin (zeige KPNA4 Proteine) IPO5 (zeige IPO5 Proteine) was identified as a novel interacting protein of SMAD1 (zeige GARS Proteine). Overexpression of IPO5 (zeige IPO5 Proteine) in various cell lines specifically increases nuclear localization of BMP receptor (zeige BMPR1A Proteine)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (zeige IPO5 Proteine) and BMP but not TGF-beta (zeige TGFB1 Proteine) R-SMADs.

  8. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (zeige TGFB1 Proteine)/Smad2 signaling pathway, but not Smad1 (zeige GARS Proteine)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  9. the findings show that TIEG1 is highly expressed in human keloids and that it directly binds and represses Smad7 (zeige SMAD7 Proteine) promoter-mediated activation of TGF-beta (zeige TGFB1 Proteine)/Smad2 signaling

  10. A significant association was found between the low expression of inhibitory protein SMAD-7 (zeige SMAD7 Proteine) and both zeta-chain-associated protein kinase (zeige CDK7 Proteine) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (zeige GARS Proteine)/8 and lower SMAD-4 (zeige SMAD4 Proteine) expression in chronic lymphocytic leukemia cells

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. Grg4 occupancy at the Xnr1 (zeige NODAL Proteine) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 from FoxH1 (zeige FOXH1 Proteine) at the Xnr1 (zeige NODAL Proteine) enhancer, an essential feature of the transcriptional switch mechanism.

  2. E2a (zeige TCF3 Proteine) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  3. GDF11 (zeige GDF11 Proteine) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  4. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. Activin A (zeige INHBA Proteine) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (zeige NANOG Proteine) and OCT4 (zeige POU5F1 Proteine),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Proteine)/OCT4 (zeige POU5F1 Proteine) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. selective inhibition of SMAD3 (zeige SMAD3 Proteine) or CCT6A (zeige CCT6A Proteine) efficiently suppresses TGF-beta (zeige TGFB1 Proteine)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 Proteine) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 Proteine) for non-small-cell lung carcinoma.

  2. results demonstrate that TGF-beta1 (zeige TGFB1 Proteine)-induced autophagy links beta-catenin (zeige CTNNB1 Proteine) and Smad (zeige SMAD1 Proteine) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (zeige CTNNB1 Proteine)/p-Smad2/ILK (zeige ILK Proteine) pathway.

  3. These results suggest that Nedd9 (zeige NEDD9 Proteine) is a Smad2/3 target gene implicated in RANKL (zeige TNFSF11 Proteine)-induced osteoclastogenesis.

  4. In conclusion, TGF-beta (zeige TGFB1 Proteine) signaling pathway may influence liver fibrosis by incorporating with YB-1 (zeige YBX1 Proteine), indicating that YB-1 (zeige YBX1 Proteine) could be a potential target for therapies against liver fibrosis.

  5. miR (zeige MLXIP Proteine)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (zeige TGFB1 Proteine) receptor 1 and SMAD2.

  6. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (zeige IHH Proteine) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  7. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (zeige TGFB1 Proteine).

  8. Data show that muscle-specific (zeige EIF3K Proteine) Smad (zeige SMAD1 Proteine) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  9. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (zeige WNT2 Proteine) pathway, and inhibition of Smad2/3 signaling and Shh (zeige SHH Proteine) pathways.

  10. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

SMAD2 Protein Überblick

Protein Überblick

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2)
  • SMAD family member 2 (smad2)
  • MAD homolog 2 (Drosophila) (smad2)
  • SMAD family member 2 (Smad2)
  • 7120426M23Rik Protein
  • fj43c06 Protein
  • hMAD-2 Protein
  • hSMAD2 Protein
  • JV18 Protein
  • JV18-1 Protein
  • Madh2 Protein
  • Madr2 Protein
  • mMad2 Protein
  • Smad-2 Protein
  • wu:fj43c06 Protein
  • Xmad2 Protein
  • XSmad2 Protein

Bezeichner auf Proteinebene für SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

GENE ID SPEZIES
100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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