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anti-SMAD, Mothers Against DPP Homolog 2 Antikörper (SMAD2)
Auf finden Sie aktuell 414 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD2 Kits (31) und SMAD2 Proteine (27) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 493 SMAD2 Produkte verfügbar.
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2

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Am meisten referenzierte anti-SMAD2 Antikörper

  1. Human Polyclonal SMAD2 Primary Antibody für EIA, WB - ABIN401419 : Yang, Huang, Chen, Lin, Chen: Leptin augments myofibroblastic conversion and fibrogenic activity of human peritoneal mesothelial cells: a functional implication for peritoneal fibrosis. in Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2007 (PubMed)
    Zeige alle 6 Referenzen für ABIN401419

  2. Human Polyclonal SMAD2 Primary Antibody für IF, ELISA - ABIN1531629 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Zeige alle 2 Referenzen für ABIN1531629

  3. Human Polyclonal SMAD2 Primary Antibody für ELISA, WB - ABIN1532649 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996 (PubMed)
    Zeige alle 2 Referenzen für ABIN1532649

  4. Human Polyclonal SMAD2 Primary Antibody für IF, WB - ABIN391546 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. in The Journal of biological chemistry 2002 (PubMed)

  5. Chicken Polyclonal SMAD2 Primary Antibody für WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. in The EMBO journal 2006 (PubMed)

  6. Chicken Polyclonal SMAD2 Primary Antibody für IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. in The Journal of biological chemistry 2008 (PubMed)

Weitere Antikörper gegen SMAD2 Interaktionspartner

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. The results of this study found that Bptf (zeige BPTF Antikörper) and TGF-beta (zeige TGFB1 Antikörper)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Antikörper) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (zeige EOMES Antikörper) a (Eomesa (zeige EOMES Antikörper)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Antikörper) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. The data showed that the effect of Activin A (zeige INHBA Antikörper) on ESCs (zeige NR2E3 Antikörper) was partially abrogated by pretreatment with an inhibitor of ALK4 (zeige ACVR1B Antikörper) (the type I receptor, ActRIB (zeige ACVR1B Antikörper)) and Smad4 (zeige SMAD4 Antikörper)-siRNA. Cumulatively, these data suggest that Activin A (zeige INHBA Antikörper) promotes the secretion of estradiol from ESCs (zeige NR2E3 Antikörper) by increasing the expression of P450arom (zeige CYP19A1 Antikörper) via the ALK4 (zeige ACVR1B Antikörper)-Smad (zeige SMAD1 Antikörper) pathway. These findings indicate the ALK4 (zeige ACVR1B Antikörper)-Smad (zeige SMAD1 Antikörper) pathway may promote ectopic lesion survival and developmen

  2. miR (zeige MLXIP Antikörper)-128 regulates the differentiation of human hair follicle mesenchymal stem cells into smooth muscle cells via targeting SMAD2, a main transcription regulator in TGF-beta (zeige TGFB1 Antikörper) signaling pathway involving smooth muscle cell differentiation.

  3. Smad2 and Smad3 (zeige SMAD3 Antikörper) possess differential sensitivities in relaying TGFbeta (zeige TGFB1 Antikörper) signaling and have distinct roles in regulating early developmental events.

  4. Results provide evidence that miR (zeige MLXIP Antikörper)-148a decreases the expression of TGFbeta2 and SMAD2 in gastric cancer cells through binding to their 3'UTRs.

  5. This study describes several miRNA families with a prognostic role in the NACT setting. It also confirms that concomitant analysis of P-Smad2 and miR-181a-5p in surgical samples may be capable of identifying those ovarian cancer patients with poor outcome and little chance of response to Pt-based NACT

  6. These findings pinpoint that TGF-beta (zeige TGFB1 Antikörper) represses miR (zeige MLXIP Antikörper)-30d through a Smad2/3-HDAC3 (zeige HDAC3 Antikörper)-NCoR (zeige NCOR1 Antikörper) repression complex and provide novel insights into a potential target for the treatment of podocyte injury-associated glomerulopathies.

  7. Smad2 enhances TRAIL-induced apoptosis in activated hepatic stellate cells, which facilitates the resolution of hepatic fibrosis

  8. Suggest that greater tumor associated macrophage density, strong Hexim1 (zeige HEXIM1 Antikörper) expression, strong SMAD2 expression, and mild SMAD7 (zeige SMAD7 Antikörper) expression play important roles in the progression of prostate adenocarcinoma.

  9. MiR (zeige MLXIP Antikörper)-425 functions as an oncogene (zeige RAB1A Antikörper) by targeting the 3'-UTR (zeige UTS2R Antikörper) of SMAD2 in esophageal squamous cell carcinoma.

  10. The present study thus proposed SEB (zeige SETBP1 Antikörper) as an agent able to significantly reduce Smad2/3 expression in colon cancer cells, provoking moderate TGFb (zeige TGFB1 Antikörper) growth signaling and the reduction of tumor cell proliferation.

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. E2a (zeige TCF3 Antikörper) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  2. GDF11 (zeige GDF11 Antikörper) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  3. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (zeige TGFB1 Antikörper).

  2. Data show that muscle-specific (zeige EIF3K Antikörper) Smad (zeige SMAD1 Antikörper) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  3. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (zeige WNT2 Antikörper) pathway, and inhibition of Smad2/3 signaling and Shh (zeige SHH Antikörper) pathways.

  4. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

  5. Smad2 and Smad3 (zeige SMAD3 Antikörper) oppositely modify STAT3 (zeige STAT3 Antikörper)-induced transcription of IL-17A (zeige IL17A Antikörper) and retinoic acid receptor (zeige RARA Antikörper)-related orphan nuclear receptor (zeige NR1D1 Antikörper), RORgammat encoded by Rorc (zeige RORC Antikörper), by acting as a co-activator and co-repressor of STAT3 (zeige STAT3 Antikörper), respectively.

  6. Endoplasmic reticulum stress in hepatic stellar cells promotes liver fibrosis by inducing over expression of SMAD2.

  7. pSmad3L-Ser (zeige SIGLEC1 Antikörper) signalling correlates with carcinogenesis of colon tumors and this work supports the hypothesis that pSmad2/3L-Thr (zeige TRH Antikörper) immunostaining-positive cells are cancer stem cells.

  8. These results suggest that TGF-beta regulates RANKL-induced osteoclastogenesis through reciprocal cooperation between Smad2/3 and c-Fos.

  9. Treatment with geniposide almost completely blocked the phosphorylation of Smad2/3, extracellular signal-regulated kinase (ERK (zeige EPHB2 Antikörper)) and Akt (zeige AKT1 Antikörper) in AML12 cells.

  10. Deficiency of MKP5 (zeige DUSP10 Antikörper) resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 (zeige DUSP10 Antikörper) critically controls inflammation in white adipose tissue and the development of metabolic disorders

SMAD2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) Antikörper
  • SMAD family member 2 (smad2) Antikörper
  • MAD homolog 2 (Drosophila) (smad2) Antikörper
  • SMAD family member 2 (Smad2) Antikörper
  • 7120426M23Rik Antikörper
  • fj43c06 Antikörper
  • hMAD-2 Antikörper
  • hSMAD2 Antikörper
  • JV18 Antikörper
  • JV18-1 Antikörper
  • Madh2 Antikörper
  • Madr2 Antikörper
  • mMad2 Antikörper
  • Smad-2 Antikörper
  • wu:fj43c06 Antikörper
  • Xmad2 Antikörper
  • XSmad2 Antikörper

Bezeichner auf Proteinebene für SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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