anti-SMAD2 (SMAD2) Antikörper

Bezeichnung:
anti-SMAD, Mothers Against DPP Homolog 2 Antikörper (SMAD2)
Auf www.antikoerper-online.de finden Sie aktuell 424 SMAD, Mothers Against DPP Homolog 2 (SMAD2) Antikörper von 30 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SMAD2 Kits (43) und SMAD2 Proteine (29) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 516 SMAD2 Produkte verfügbar.
Synonyme:
7120426M23Rik, fj43c06, hMAD-2, hSMAD2, JV18, JV18-1, Madh2, Madr2, mMad2, Smad-2, wu:fj43c06, Xmad2, XSmad2

Meistgesuchte Reaktivitäten zu anti-SMAD2 (SMAD2) Antikörper

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anti-Human SMAD2 Antikörper:

anti-Mouse (Murine) SMAD2 Antikörper:

anti-Rat (Rattus) SMAD2 Antikörper:

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Am meisten referenzierte anti-SMAD2 Antikörper

  1. Human Polyclonal SMAD2 Primary Antibody für IF, IHC - ABIN1532651 : Zhang, Feng, We, Derynck: Receptor-associated Mad homologues synergize as effectors of the TGF-beta response. in Nature 1996 (PubMed)
    Zeige alle 2 Referenzen für 1532651

  2. Human Polyclonal SMAD2 Primary Antibody für ELISA, WB - ABIN1532650 : Eppert, Scherer, Ozcelik, Pirone, Hoodless, Kim, Tsui, Bapat, Gallinger, Andrulis, Thomsen, Wrana, Attisano: MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma. in Cell 1996 (PubMed)
    Zeige alle 2 Referenzen für 1532650

  3. Human Polyclonal SMAD2 Primary Antibody für IHC (p), IHC - ABIN316295 : Lee, Lee, Bae, Jung: Abnormal liver differentiation and excessive angiogenesis in mice lacking Runx3. in Histochemistry and cell biology 2013 (PubMed)

  4. Cow (Bovine) Polyclonal SMAD2 Primary Antibody für WB - ABIN2780721 : Zheng, Zugates, Lu, Shi, Bai, Lee: Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. in The EMBO journal 2006 (PubMed)

  5. Human Polyclonal SMAD2 Primary Antibody für IF, WB - ABIN391546 : Funaba, Zimmerman, Mathews: Modulation of Smad2-mediated signaling by extracellular signal-regulated kinase. in The Journal of biological chemistry 2002 (PubMed)

  6. Cow (Bovine) Polyclonal SMAD2 Primary Antibody für IHC, WB - ABIN2779412 : Antonson, Jakobsson, Almlöf, Guldevall, Steffensen, Gustafsson: RAP250 is a coactivator in the transforming growth factor beta signaling pathway that interacts with Smad2 and Smad3. in The Journal of biological chemistry 2008 (PubMed)

Weitere Antikörper gegen SMAD2 Interaktionspartner

Zebrafish SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. The results of this study found that Bptf (zeige BPTF Antikörper) and TGF-beta (zeige TGFB1 Antikörper)/Smad2 mediate nucleosome remodeling to regulate wnt8a (zeige WNT8A Antikörper) expression and hence neural posteriorization.

  2. Smad2 and Eomesodermin (zeige EOMES Antikörper) a (Eomesa (zeige EOMES Antikörper)) bind common genomic regions proximal to genes involved in mesoderm and endoderm formation, suggesting Eomesa (zeige EOMES Antikörper) forms a general component of the Smad2 signalling complex in zebrafish.

  3. These results reveal that kinesin-mediated transport of Smad2 along microtubules to the receptors is an essential step in ligand-induced Smad2 activation.

  4. study systemically uncovers a large number of Smad2 targets in early gastrulas and suggests cooperative roles of Smad2 and other transcription factors in controlling target gene transcription

  5. Nodal signaling and mesendoderm induction depend on Smad2/3 and suggest that transforming growth factor-beta signals other than Nodal also contribute to Smad2/3 signaling and embryonic patterning.

  6. Smad2/3 activities play important roles not only in mesendodermal development but also in neural development during early vertebrate embryogenesis

Human SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. selective inhibition of SMAD3 (zeige SMAD3 Antikörper) or CCT6A (zeige CCT6A Antikörper) efficiently suppresses TGF-beta (zeige TGFB1 Antikörper)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 Antikörper) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 Antikörper) for non-small-cell lung carcinoma.

  2. In response to TGF-beta (zeige TGFB1 Antikörper), RASSF1A (zeige RASSF1 Antikörper) is recruited to TGF-beta (zeige TGFB1 Antikörper) receptor I and targeted for degradation by the co-recruited E3 ubiquitin ligase (zeige MUL1 Antikörper) ITCH. RASSF1A (zeige RASSF1 Antikörper) degradation is necessary to permit Hippo pathway effector YAP1 (zeige YAP1 Antikörper) association with SMADs and subsequent nuclear translocation of receptor-activated SMAD2.

  3. Smad2 is a key scaffold, allowing RIN1 (zeige RIN1 Antikörper) to act as a GTP (zeige AK3 Antikörper) exchange factor for MFN2 (zeige MFN2 Antikörper)-GTPase (zeige RACGAP1 Antikörper) activation to promote mitochondrial ATP synthesis and suppress superoxide production during mitochondrial fusion.

  4. Ang (zeige ANG Antikörper) down-regulate the expression of Col (zeige HDAC1 Antikörper)-I, alpha-SMA (zeige SMN1 Antikörper) and TGF-beta1 (zeige TGFB1 Antikörper)/Smad2/3 and subsequently inhibits fibroblast-myofibroblast transition.

  5. The nuclear importin (zeige KPNA4 Antikörper) IPO5 (zeige IPO5 Antikörper) was identified as a novel interacting protein of SMAD1 (zeige GARS Antikörper). Overexpression of IPO5 (zeige IPO5 Antikörper) in various cell lines specifically increases nuclear localization of BMP receptor (zeige BMPR1A Antikörper)-activated SMADs (R-SMADs) confirming a functional relationship between IPO5 (zeige IPO5 Antikörper) and BMP but not TGF-beta (zeige TGFB1 Antikörper) R-SMADs.

  6. Our findings suggest a stronger chondrogenic potential of CD105(+) SMSCs in comparison to that of CD105(-) SMSCs and that CD105 enhances chondrogenesis of SMSCs by regulating TGF-beta (zeige TGFB1 Antikörper)/Smad2 signaling pathway, but not Smad1 (zeige GARS Antikörper)/5. Our study provides a better understanding of CD105 with respect to chondrogenic differentiation.

  7. the findings show that TIEG1 (zeige KLF10 Antikörper) is highly expressed in human keloids and that it directly binds and represses Smad7 (zeige SMAD7 Antikörper) promoter-mediated activation of TGF-beta (zeige TGFB1 Antikörper)/Smad2 signaling

  8. A significant association was found between the low expression of inhibitory protein SMAD-7 (zeige SMAD7 Antikörper) and both zeta-chain-associated protein kinase (zeige CDK7 Antikörper) 70-negative cells (p = 0.04) and lower apoptotic index (p = 0.004). No differences were observed in SMAD-2/3 expression. In conclusion, our results demonstrate a significant correlation between greater SMAD-1 (zeige GARS Antikörper)/8 and lower SMAD-4 (zeige SMAD4 Antikörper) expression in chronic lymphocytic leukemia cells

  9. High expression of SMAD2 is associated with colorectal carcinoma.

  10. this study shows that tolfenamic acid inhibits growth of colon cancer cells through downregulation of Smad2

Xenopus laevis SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. Grg4 (zeige TLE4 Antikörper) occupancy at the Xnr1 (zeige NODAL Antikörper) enhancer significantly decreases with Smad2 overexpression.Nodal-activated Smad2 physically displaces Grg4 (zeige TLE4 Antikörper) from FoxH1 (zeige FOXH1 Antikörper) at the Xnr1 (zeige NODAL Antikörper) enhancer, an essential feature of the transcriptional switch mechanism.

  2. E2a (zeige TCF3 Antikörper) is necessary to drive transcription of Smad2/3 target genes, including critical regulators of dorsal cell fate and morphogenesis

  3. GDF11 (zeige GDF11 Antikörper) has a central role in the activation of Smad2 phosphorylation in tailbud stage Xenopus embryos.

  4. XPIASy functions as an essential negative regulator of the XSmad2 pathway to ensure proper mesoderm induction at the appropriate time and in the appropriate region.

Pig (Porcine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. Activin A (zeige INHBA Antikörper) and overexpression of SMAD2/3 significantly promoted expressions of porcine NANOG (zeige NANOG Antikörper) and OCT4 (zeige POU5F1 Antikörper),maintaining induced pluripotent stem cell self-renewal through up-regulation of Nanog (zeige NANOG Antikörper)/OCT4 (zeige POU5F1 Antikörper) expression.

Cow (Bovine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. the present work provides evidence supporting a functional role of SMAD2/3 in bovine early embryogenesis

  2. Mechanical compression not only with physiological but also with excessive stress can activate Smad2/3P signaling, which is known to be protective for articular cartilage and to block chondrocyte terminal differentiation.

  3. a detailed computational model for TGF-beta (zeige TGFB1 Antikörper) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Antikörper)/5/8 and Smad2/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Antikörper).

Mouse (Murine) SMAD, Mothers Against DPP Homolog 2 (SMAD2) Interaktionspartner

  1. selective inhibition of SMAD3 (zeige SMAD3 Antikörper) or CCT6A (zeige CCT6A Antikörper) efficiently suppresses TGF-beta (zeige TGFB1 Antikörper)-mediated metastasis. Findings provide a mechanism that directs TGF-beta (zeige TGFB1 Antikörper) signaling toward its prometastatic arm and may contribute to the development of therapeutic strategies targeting TGF-beta (zeige TGFB1 Antikörper) for non-small-cell lung carcinoma.

  2. results demonstrate that TGF-beta1 (zeige TGFB1 Antikörper)-induced autophagy links beta-catenin (zeige CTNNB1 Antikörper) and Smad (zeige SMAD1 Antikörper) signaling to promote epithelial-mesenchymal transition in C1.1 cells through a novel pY654-beta-catenin (zeige CTNNB1 Antikörper)/p-Smad2/ILK (zeige ILK Antikörper) pathway.

  3. These results suggest that Nedd9 (zeige NEDD9 Antikörper) is a Smad2/3 target gene implicated in RANKL (zeige TNFSF11 Antikörper)-induced osteoclastogenesis.

  4. In conclusion, TGF-beta (zeige TGFB1 Antikörper) signaling pathway may influence liver fibrosis by incorporating with YB-1 (zeige YBX1 Antikörper), indicating that YB-1 (zeige YBX1 Antikörper) could be a potential target for therapies against liver fibrosis.

  5. miR (zeige MLXIP Antikörper)-27b is an anti-fibrotic microRNA that inhibits fibroblast activation by targeting TGFbeta (zeige TGFB1 Antikörper) receptor 1 and SMAD2.

  6. hese studies revealed that Smad2 plays an essential role in the development of the growth plate, that both Smads 2 and 3 inhibit Ihh (zeige IHH Antikörper) expression in the neonatal growth plate, and suggested they accomplish this by binding to distinct SBEs, mediating assembly of distinct repressive complexes.

  7. This study found evidence of increased leukocyte phosphorylated-Smad2/3 staining in both single leukocytes and platelet-leukocyte aggregates in mice that developed aortic valve stenosis, suggesting the presence of increased circulating active TGF-beta1 (zeige TGFB1 Antikörper).

  8. Data show that muscle-specific (zeige EIF3K Antikörper) Smad (zeige SMAD1 Antikörper) proteins Smad2/3-deficient mice exhibited significant resistance to denervation-induced muscle atrophy.

  9. these data demonstrate that the SMI drives ES cells to skeletal muscle via concerted activation of the Wnt (zeige WNT2 Antikörper) pathway, and inhibition of Smad2/3 signaling and Shh (zeige SHH Antikörper) pathways.

  10. Arsenite disrupts zinc-dependent TGFbeta2-SMAD2/3 activity during murine cardiac progenitor cell differentiation.

SMAD2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants have been observed for this gene.

Alternative names and synonyms associated with SMAD2

  • SMAD family member 2 (SMAD2) Antikörper
  • SMAD family member 2 (smad2) Antikörper
  • MAD homolog 2 (Drosophila) (smad2) Antikörper
  • SMAD family member 2 (Smad2) Antikörper
  • 7120426M23Rik Antikörper
  • fj43c06 Antikörper
  • hMAD-2 Antikörper
  • hSMAD2 Antikörper
  • JV18 Antikörper
  • JV18-1 Antikörper
  • Madh2 Antikörper
  • Madr2 Antikörper
  • mMad2 Antikörper
  • Smad-2 Antikörper
  • wu:fj43c06 Antikörper
  • Xmad2 Antikörper
  • XSmad2 Antikörper

Bezeichner auf Proteinebene für SMAD2

SMAD, mothers against DPP homolog 2 , MAD (mothers against decapentaplegic, Drosophila) homolog 2 , SMA- and MAD-related protein 2 , SMAD 2 , SMAD family member 2 , mothers against DPP homolog 2 , mothers against decapentaplegic homolog 2 , MAD homolog 2 , Sma- and Mad-related protein 2 , mother against DPP homolog 2 , mothers against decapentaplegic-like 2 , Smad 2 , mad-related protein 2

GENE ID SPEZIES
100033843 Equus caballus
496586 Xenopus (Silurana) tropicalis
30639 Danio rerio
4087 Homo sapiens
432023 Xenopus laevis
395247 Gallus gallus
480144 Canis lupus familiaris
100155304 Sus scrofa
516010 Bos taurus
17126 Mus musculus
29357 Rattus norvegicus
455407 Pan troglodytes
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