anti-CDK4 (CDK4) Antikörper

Bezeichnung:
anti-Cyclin-Dependent Kinase 4 Antikörper (CDK4)
Auf www.antikoerper-online.de finden Sie aktuell 320 Cyclin-Dependent Kinase 4 (CDK4) Antikörper von 33 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen CDK4 Proteine (41) und CDK4 Kits (35) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 409 CDK4 Produkte verfügbar.
Synonyme:
8-6, cdk, cdk4, cdk4/6, CG5072, CMM3, Crk3, dCdk4, DmCdk4, Dmel\\CG5072, l(2)05428, l(2)0671, l(2)k06503, l(2)s4639, l(2)sh0671, Pk53C, Pk?7, PSK-J3, xcdk4, zgc:153726

Meistgesuchte Reaktivitäten zu anti-CDK4 (CDK4) Antikörper

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anti-Human CDK4 Antikörper:

anti-Mouse (Murine) CDK4 Antikörper:

anti-Rat (Rattus) CDK4 Antikörper:

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Am meisten referenzierte anti-CDK4 Antikörper

  1. Human Monoclonal CDK4 Primary Antibody für IHC (f), IF - ABIN967778 : Angus, Wheeler, Ranmal, Zhang, Markey, Mathews, Knudsen: Retinoblastoma tumor suppressor targets dNTP metabolism to regulate DNA replication. in The Journal of biological chemistry 2002 (PubMed)
    Zeige alle 5 Referenzen für 967778

  2. Human Monoclonal CDK4 Primary Antibody für IP, WB - ABIN967404 : Graña, Reddy: Cell cycle control in mammalian cells: role of cyclins, cyclin dependent kinases (CDKs), growth suppressor genes and cyclin-dependent kinase inhibitors (CKIs). in Oncogene 1995 (PubMed)
    Zeige alle 3 Referenzen für 967404

  3. Dog (Canine) Monoclonal CDK4 Primary Antibody für BI, IHC (fro) - ABIN967650 : Depoortere, Van Keymeulen, Lukas, Costagliola, Bartkova, Dumont, Bartek, Roger, Dremier: A requirement for cyclin D3-cyclin-dependent kinase (cdk)-4 assembly in the cyclic adenosine monophosphate-dependent proliferation of thyrocytes. in The Journal of cell biology 1998 (PubMed)
    Zeige alle 3 Referenzen für 967650

  4. Human Polyclonal CDK4 Primary Antibody für FACS, IF - ABIN391751 : Mori, Yang, Kawamata, Miller, Mizoguchi, Koeffler: Absence of R24C mutation of the CDK4 gene in leukemias and solid tumors. in International journal of hematology 2003 (PubMed)
    Zeige alle 3 Referenzen für 391751

  5. Human Polyclonal CDK4 Primary Antibody für IF (p), IHC (p) - ABIN671166 : Zhou, Liu, Cai, Liu, Jiang, Wang: Protective effects of ginsenoside Rg1 on aging Sca?1+ hematopoietic cells. in Molecular medicine reports 2015 (PubMed)
    Zeige alle 2 Referenzen für 671166

  6. Human Monoclonal CDK4 Primary Antibody für IF, WB - ABIN1106647 : Demetrick, Zhang, Beach: Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes. in Cytogenetics and cell genetics 1994 (PubMed)
    Zeige alle 2 Referenzen für 1106647

  7. Human Monoclonal CDK4 Primary Antibody für IHC (f), IP - ABIN967647 : Johnson, Walker: Cyclins and cell cycle checkpoints. in Annual review of pharmacology and toxicology 1999 (PubMed)
    Zeige alle 2 Referenzen für 967647

  8. Human Monoclonal CDK4 Primary Antibody für ICC, IF - ABIN267545 : Brookes, Gagrica, Sanij, Rowe, Gregory, Hara, Peters: Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence. in Cell cycle (Georgetown, Tex.) 2015 (PubMed)

  9. Cow (Bovine) Polyclonal CDK4 Primary Antibody für WB - ABIN2792086 : Elkahloun, Krizman, Wang, Hofmann, Roe, Meltzer: Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers. in Genomics 1997 (PubMed)

  10. Cow (Bovine) Polyclonal CDK4 Primary Antibody für ICC, IF - ABIN441316 : Huang, Kao, Toh, Lin, Chou, Hu, Lu, Liou, Chao, Hour, Pu: UBE2M-mediated p27(Kip1) degradation in gemcitabine cytotoxicity. in Biochemical pharmacology 2011 (PubMed)

Weitere Antikörper gegen CDK4 Interaktionspartner

Zebrafish Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. Expression of cells a mutant CDK4 (CDK4(R24C)) in beta-cells enhanced beta-cell replication. CDK4(R24C) also dampened compensatory beta-cell neogenesis in larvae and improved glucose tolerance in adult zebrafish.

Human Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. Specific E2Fs also have prognostic value in breast cancer, independent of clinical parameters. We discuss here recent advances in understanding of the RB-E2F (zeige E2F1 Antikörper) pathway in breast cancer. We also discuss the application of genome-wide genetic screening efforts to gain insight into synthetic lethal interactions of CDK4/6 inhibitors in breast cancer for the development of more effective combination therapies.

  2. p16 (zeige CDKN2A Antikörper) in combination with MDM2 (zeige MDM2 Antikörper) and CDK4 immunohistochemistry may help in the differential diagnosis of atypical lipomatous tumor/well-differentiated liposarcoma and dedifferentiated liposarcoma.

  3. conclude that p16 (zeige CDKN2A Antikörper) is highly sensitive for retroperitoneal DDL. However, the lack of specificity limits the diagnostic utility compared with the more established markers MDM2 (zeige MDM2 Antikörper) and CDK4

  4. CDK4 overexpression is associated with cancer.

  5. High CDK4 expression is associated with Melanoma.

  6. Staining for MDM2 (zeige MDM2 Antikörper) and CDK4 was noted in 25/56 and 23/56 atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL), respectively, giving a sensitivity of 45% and 41% and a specificity of 98% and 92%. Staining was noted exclusively in the nuclei of atypical cells and not in the nuclei of adipocytes. Staining for MDM2 (zeige MDM2 Antikörper) and CDK4 occurred in 2/125 and 10/117 benign lipomatous lesions, respectively.

  7. Data suggest that CDK4 (cyclin-dependent kinase 4) is degraded by anaphase-promoting complex/cyclosome (APC (zeige APC Antikörper)/C) during metaphase-anaphase transition while its main regulator, cyclin D1 (zeige CCND1 Antikörper), remains intact but is sequestered in cytoplasm; CDK4 protein reaccumulates in the following G1 phase and shuttles between nucleus and cytoplasm to facilitate nuclear import of cyclin D1 (zeige CCND1 Antikörper); without CDK4, cyclin D1 (zeige CCND1 Antikörper) cannot enter nucleus.

  8. Cdk4 inhibition leads to directing human mesenchymal stem cells to a multipotent neurogenic fate by inactivating Smads-STAT3 (zeige STAT3 Antikörper) signaling.

  9. Reduced SIRT2 (zeige SIRT2 Antikörper) expression during tumorigenesis failed to repress cyclindependent kinase 4 expression, which eventually led to accelerated cell proliferation.

  10. older patients with head and neck squamous cell carcinoma and lung cancer have raised serums CDK4 levels, which has the potential to emerge as a biomarker in clinical practice

Pig (Porcine) Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. The in vitro cultivation of cumulus cells was associated with cell proliferation and that Cx43 (zeige GJA1 Antikörper) and Cdk4 gene expression was upregulated after in vitro cultivation, resulting in significantly higher protein levels.

Mouse (Murine) Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. PD 0332991 (PD), an FDA-approved selective inhibitor of cyclin-dependent kinase 4/6 (CDK4/6), prevents radiation-induced lethal intestinal injury in mice. Treating mice with PD or a structurally distinct CDK4/6 inhibitor prior to radiation blocked proliferation and crypt apoptosis and improved crypt regeneration.

  2. Cdk4 protein

  3. The results demonstrate a unique CDK4-mediated mitochondrial communication that allows cells to sense environmental genotoxic stress and boost mitochondrial homeostasis by enhancing phosphorylation and activation of MnSOD (zeige SOD2 Antikörper).

  4. a crucial role of RXRa (zeige RXRA Antikörper) in suppression of UVB-induced melanomas in the context of driver mutations such as activated CDK4(R24C/R24C) or oncogenic NRAS (zeige NRAS Antikörper)(Q61K) and altered expression of p53 (zeige TP53 Antikörper) and PTEN (zeige PTEN Antikörper)

  5. Our data indicate that Cdk2 (zeige CDK2 Antikörper) and Cdk4 play important overlapping roles in homeostatic and stress hematopoiesis, which need to be considered when using broad-spectrum cyclin-dependent kinase (zeige CDK1 Antikörper) inhibitors for cancer therapy.

  6. CDK4 is a critical downstream target of MEN1 (zeige MEN1 Antikörper)-dependent tumor suppression and is required for tumorigenic proliferation in the pituitary and pancreatic islet, whereas CDK2 (zeige CDK2 Antikörper) is dispensable for tumorigenesis in these neuroendocrine cell types.

  7. Cdk4 and Cdk6 (zeige CDK6 Antikörper) cooperate in hematopoietic tumor development and suggest a role for Cdk6 (zeige CDK6 Antikörper) in sequestering INK4 (zeige CDKN2A Antikörper) proteins away from Cdk4.

  8. CDK4 seems to be expressed as multiple proteins that respond differently to different shRNAs, and have previously unrecognized functions at the S-G 2/M phases of the cell cycle via mechanisms independent of binding to CCND and RB.

  9. insulin (zeige INS Antikörper) activates cyclin D1 (zeige CCND1 Antikörper)-cyclin-dependent kinase 4 (Cdk4), which, in turn, increases GCN5 (zeige KAT2A Antikörper) acetyltransferase activity and suppresses hepatic glucose production independently of cell cycle progression

  10. CDK4 deficiency markedly accelerated lymphoma development in the Emu-Myc (zeige MYC Antikörper) transgenic model of B lymphoma

Fruit Fly (Drosophila melanogaster) Cyclin-Dependent Kinase 4 (CDK4) Interaktionspartner

  1. The results indicate that the precise regulation of neuronal Cdk4 activity is important to limit mitochondrial reactive oxygen species production and prevent neurodegeneration.

  2. CDK4 activity regulates mitobiogenesis by the activation of NRF-1 (zeige NRF1 Antikörper) and consequent induction of Tfam (zeige TFAM Antikörper) and mitochondrial ribossomal transcription.

  3. Delg and cyclin D/Cdk4 have roles in nutritional control of mitochondrial biogenesis in the Drosophila adipose tissue

  4. Cyclin D-cdk4 is not a master regulator of cell multiplication in Drosophila embryos

  5. mRpL12 (zeige MRPL12 Antikörper) is required for CycD/Cdk4-induced cell growth

  6. Our data suggest that the growth-specific function of CycD/Cdk4 is conserved from arthropods to mammals.

CDK4 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported.

Alternative names and synonyms associated with CDK4

  • cyclin-dependent kinase 4 (cdk4) Antikörper
  • cyclin-dependent kinase 4 (CDK4) Antikörper
  • cyclin-dependent kinase 4 (Cdk4) Antikörper
  • Cyclin-dependent kinase 4 (Cdk4) Antikörper
  • 8-6 Antikörper
  • cdk Antikörper
  • cdk4 Antikörper
  • cdk4/6 Antikörper
  • CG5072 Antikörper
  • CMM3 Antikörper
  • Crk3 Antikörper
  • dCdk4 Antikörper
  • DmCdk4 Antikörper
  • Dmel\\CG5072 Antikörper
  • l(2)05428 Antikörper
  • l(2)0671 Antikörper
  • l(2)k06503 Antikörper
  • l(2)s4639 Antikörper
  • l(2)sh0671 Antikörper
  • Pk53C Antikörper
  • Pk?7 Antikörper
  • PSK-J3 Antikörper
  • xcdk4 Antikörper
  • zgc:153726 Antikörper

Bezeichner auf Proteinebene für CDK4

cell division protein kinase 4 , PSK-J3 , cyclin dependent kinase 4 , p34/cdk4 , serine/threonine kinase , Cell division protein kinase 4 , CG5072-PA , CG5072-PB , CG5072-PC , Cdk4-PA , Cdk4-PB , Cdk4-PC , Cyclin-dependent kinase 4/6 , cyclin-dependent kinase 4 , protein kinase-like 53C

GENE ID SPEZIES
777730 Danio rerio
1019 Homo sapiens
100144492 Sus scrofa
12567 Mus musculus
94201 Rattus norvegicus
481131 Canis lupus familiaris
510618 Bos taurus
100009039 Oryctolagus cuniculus
100717960 Cavia porcellus
100144756 Ovis aries
36854 Drosophila melanogaster
379406 Xenopus laevis
Ausgewählte Anbieter für anti-CDK4 (CDK4) Antikörper
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