anti-TCF7L2 (TCF7L2) Antikörper

anti-Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) Antikörper (TCF7L2)
Auf finden Sie aktuell 103 Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Antikörper von 16 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen TCF7L2 Kits (6) und TCF7L2 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 120 TCF7L2 Produkte verfügbar.
mTcf-4B, mTcf-4E, TCF-4, TCF4, TCF4B, tcf4e, TCFL2, XTCF-4
Alle Antikörper anzeigen Gen GeneID UniProt
TCF7L2 21416 Q924A0
TCF7L2 6934 Q9NQB0
TCF7L2 679869  

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Meistgesuchte Reaktivitäten zu anti-TCF7L2 (TCF7L2) Antikörper

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anti-Mouse (Murine) TCF7L2 Antikörper:

anti-Human TCF7L2 Antikörper:

anti-Rat (Rattus) TCF7L2 Antikörper:

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Am meisten referenzierte anti-TCF7L2 Antikörper

  1. Human Monoclonal TCF7L2 Primary Antibody für IF, WB - ABIN394207 : Heni, Ketterer, Thamer, Herzberg-Schäfer, Guthoff, Stefan, Machicao, Staiger, Fritsche, Häring: Glycemia determines the effect of type 2 diabetes risk genes on insulin secretion. in Diabetes 2010 (PubMed)
    Zeige alle 5 Referenzen für 394207

  2. Human Polyclonal TCF7L2 Primary Antibody für EIA, WB - ABIN955128 : Hansson, Zhou, Renström, Osmark: Molecular function of TCF7L2: Consequences of TCF7L2 splicing for molecular function and risk for type 2 diabetes. in Current diabetes reports 2010 (PubMed)
    Zeige alle 2 Referenzen für 955128

  3. Human Monoclonal TCF7L2 Primary Antibody für IHC (p), ELISA - ABIN520776 : da Silva Xavier, Loder, McDonald, Tarasov, Carzaniga, Kronenberger, Barg, Rutter: TCF7L2 regulates late events in insulin secretion from pancreatic islet beta-cells. in Diabetes 2009 (PubMed)
    Zeige alle 2 Referenzen für 520776

  4. Cow (Bovine) Polyclonal TCF7L2 Primary Antibody für WB - ABIN2777926 : Ren, Han, Wang, Zhang, Han, Luo, Zhou, Ji: Exon sequencing and association analysis of polymorphisms in TCF7L2 with type 2 diabetes in a Chinese population. in Diabetologia 2008 (PubMed)

Weitere Antikörper gegen TCF7L2 Interaktionspartner

Mouse (Murine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Interaktionspartner

  1. TCF7L2 mediates canonic Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling and c-Myc (zeige MYC Antikörper) upregulation during abnormal cardiac remodeling in heart failure and suppression of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) to c-Myc (zeige MYC Antikörper) axis can be explored for preventing and treating heart failure.

  2. These findings suggest a unique role for Tcf7l2 in generating distinct neuronal phenotypes from homogeneous progenitor population.

  3. Tcf7l2 may be involved in maintenance of stem/progenitor cells properties.

  4. results indicate that miR (zeige MLXIP Antikörper)-181a-5p promotes 3T3-L1 preadipocyte differentiation and adipogenesis through regulating TGFbeta (zeige TGFB1 Antikörper)/Smad (zeige SMAD1 Antikörper) and Wnt (zeige WNT2 Antikörper) signaling pathway by directly targeting Smad7 (zeige SMAD7 Antikörper) and Tcf7l2

  5. Tcf7l2 protein levels decline upon initiation of endocrine differentiation in vivo, disclosing the downregulation of this factor in the developing endocrine compartment.

  6. Kaiso (zeige ZBTB33 Antikörper) and Sox10 (zeige SOX10 Antikörper) sequentially interact with Tcf7l2 to coordinate the maturation of oligodendrocyte.

  7. Tcf7l2 plays a cell autonomous role in the control of beta cell function and mass, serving as an important regulator of gene expression and islet cell coordination

  8. Tcf7l2 is regulating proinsulin (zeige INS Antikörper) expression directly via Isl1 (zeige ISL1 Antikörper), Ins1 and indirectly via MafA (zeige MAFA Antikörper), NeuroD1 (zeige NEUROD1 Antikörper) and Pdx1 (zeige PDX1 Antikörper).

  9. Transcription factor 7-like 2 positively regulates neonatal and postnatal mouse oligodendrocyte differentiation during developmental myelination and remyelination in a manner independent of the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway.

  10. TCF7L2 expressed in the pancreatic beta cells plays a crucial role in glucose metabolism through regulation of the beta cell mass.

Zebrafish Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Interaktionspartner

  1. Tcf7l2 is essential for lateralized fate selection by habenular neurons that can differentiate along two alternative pathways, thereby leading to major neural circuit asymmetries.

  2. Dorsal and ventral habenulae develop in different regions of prosomere 2. In the process of ventral habenula formation, functional tcf7l2 gene activity is required and in its absence, ventral habenular neurons do not develop.

  3. In embryos, the tcf4 gene is highly regulated at the level of RNA splicing such that the variant proteins that are produced contain or lack domains proposed to be essential in repression or activation of transcription.

  4. Study underscores the involvement of Tcf4 in maintaining proliferative self-renewal in the intestine throughout life.

  5. This study reveals that Tcf4 (tcf7l2) is the major effector of Wnt (zeige WNT2 Antikörper) signaling in the intestine during zebrafish organogenesis.

Xenopus laevis Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Interaktionspartner

  1. XTcf4 has no repressive role but is required to activate expression of Xnr3 and chordin (zeige CHRD Antikörper) in organizer cells at the gastrula stage

  2. regulation of XTcf-4 by canonical wnt (zeige WNT2 Antikörper)-signaling is directly controlled by binding to and activating a consensus Lef/Tcf (zeige HNF4A Antikörper) binding site within its own promoter

Human Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Interaktionspartner

  1. These findings suggest that the rs7903146 locus might exert its enhancer function by interacting with HMGB1 (zeige HMGB1 Antikörper) in an allele dependent manner.

  2. TCF7L2 polymorphism is associated with colorectal cancer.

  3. Data show that FERM domain-containing protein 5 (FRMD5) is regulated by both beta-catenin and transcription factor 7-Like 2 protein (TCF7L2) in colon cancer cells.

  4. the variation of the TCF7L2 gene in three Amerindian populations

  5. These data define the mechanism responsible for the repressive effects of nitric oxide (NO) on the transcriptional activity of beta-catenin (zeige CTNNB1 Antikörper) and link eNOS (zeige NOS3 Antikörper)-derived NO to the modulation by VEGF (zeige VEGFA Antikörper) of Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper)-induced endothelial cell proliferation.

  6. we show that TopoIIalpha forms protein-protein interactions with beta-catentin and TCF4 (zeige TCF4 Antikörper) and interacts with Wnt (zeige WNT2 Antikörper) response elements (WREs) and promoters of direct target genes of TCF (zeige HNF4A Antikörper) transcription, including: MYC (zeige MYC Antikörper), vimentin (zeige VIM Antikörper), AXIN2 (zeige AXIN2 Antikörper) and LEF1 (zeige LEF1 Antikörper)

  7. novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women

  8. GWAS identified two known loci (TCF7L2 and KCNQ1 (zeige KCNQ1 Antikörper)) reaching genome-wide significance levels in Hispanic type 2 diabetes patients.

  9. Nuclear TCF4/TCF7L2 (zeige TCF4 Antikörper) expression affected the survival of patients with esophageal squamous cell carcinoma (ESCC). Positive expression of TCF4/TCF7L2 (zeige TCF4 Antikörper) was correlated with a poor prognosis after a curative operation in patients with ESCC.

  10. The results provide a strong evidence for independent association between type 2 diabetes mellitus and SNPs for in TCF7L2 and SLC30A8 (zeige SLC30A8 Antikörper).

Cow (Bovine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Interaktionspartner

  1. findings report an independent confirmation of the association of the TCF7L2 (zeige TCF4 Antikörper) gene with milk yield and composition traits.

Pig (Porcine) Transcription Factor 7-Like 2 (T-Cell Specific, HMG-Box) (TCF7L2) Interaktionspartner

  1. Genes implied in human type 2 diabetes development, TCF7L2, WFS1 (zeige WFS1 Antikörper), FTO (zeige FTO Antikörper), SLC30A8 (zeige SLC30A8 Antikörper), and GCKR (zeige GCKR Antikörper), were mapped on Sus scrofa chromosomes 14, 8, 6, 4, and 3, respectively. Only TCF7L2 was significantly associated with five fat traits in pigs.

TCF7L2 Antigen-Profil

Beschreibung des Gens

This gene encodes a high mobility group (HMG) box-containing transcription factor that plays a key role in the Wnt signaling pathway. The protein has been implicated in blood glucose homeostasis. Genetic variants of this gene are associated with increased risk of type 2 diabetes. Several transcript variants encoding multiple different isoforms have been found for this gene.

Alternative names and synonyms associated with TCF7L2

  • transcription factor 7-like 2 (T-cell specific, HMG-box) (LOC100229459) Antikörper
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (TCF7L2) Antikörper
  • transcription factor 7 like 2, T cell specific, HMG box (Tcf7l2) Antikörper
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (tcf7l2) Antikörper
  • transcription factor 7-like 2 (T-cell specific, HMG-box) (Tcf7l2) Antikörper
  • mTcf-4B Antikörper
  • mTcf-4E Antikörper
  • TCF-4 Antikörper
  • TCF4 Antikörper
  • TCF4B Antikörper
  • tcf4e Antikörper
  • TCFL2 Antikörper
  • XTCF-4 Antikörper

Bezeichner auf Proteinebene für TCF7L2

transcription factor 7-like 2 (T-cell specific, HMG-box) , HMG box transcription factor 4 , T-cell factor 4 , T-cell-specific transcription factor 4 , mTCF-4 , transcription factor 7-like 2 , transcription factor 7-like 2, T-cell specific, HMG-box , transcription factor tcf4 , T-cell factor XTCF-4A , transcription factor Tcf4 , T-cell factor-4 variant A , T-cell factor-4 variant B , T-cell factor-4 variant C , T-cell factor-4 variant D , T-cell factor-4 variant E , T-cell factor-4 variant F , T-cell factor-4 variant G , T-cell factor-4 variant H , T-cell factor-4 variant I , T-cell factor-4 variant J , T-cell factor-4 variant K , T-cell factor-4 variant L , T-cell factor-4 variant M , T-cell factor-4 variant X2 , hTCF-4

100229459 Taeniopygia guttata
100545943 Meleagris gallopavo
21416 Mus musculus
30510 Danio rerio
399164 Xenopus laevis
395508 Gallus gallus
6934 Homo sapiens
540481 Bos taurus
679869 Rattus norvegicus
100153922 Sus scrofa
486894 Canis lupus familiaris
Ausgewählte Anbieter für anti-TCF7L2 (TCF7L2) Antikörper
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