anti-FZD4 (FZD4) Antikörper

Bezeichnung:
anti-Frizzled Family Receptor 4 Antikörper (FZD4)
Auf www.antikoerper-online.de finden Sie aktuell 136 Frizzled Family Receptor 4 (FZD4) Antikörper von 23 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen FZD4 Proteine (15) und FZD4 Kits (9) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 173 FZD4 Produkte verfügbar.
Synonyme:
anon-WO0170980.10, anon-WO0170980.11, CD344, CG4626, Dfz4, Dmel\\CG4626, Dm Fz4, EVR1, FEVR, frizzled4, FZ-4, fz1, fz4, FZD4S, FzE4, GPCR, hFz4, zg01

Meistgesuchte Reaktivitäten zu anti-FZD4 (FZD4) Antikörper

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anti-Human FZD4 Antikörper:

anti-Rat (Rattus) FZD4 Antikörper:

anti-Mouse (Murine) FZD4 Antikörper:

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Am meisten referenzierte anti-FZD4 Antikörper

  1. Human Polyclonal FZD4 Primary Antibody für EIA, WB - ABIN951305 : Ells, Guernsey, Wallace, Zheng, Vincer, Allen, Ingram, DaSilva, Siebert, Sheidow, Beis, Robitaille: Severe retinopathy of prematurity associated with FZD4 mutations. in Ophthalmic genetics 2010 (PubMed)
    Zeige alle 5 Referenzen für 951305

  2. Cow (Bovine) Polyclonal FZD4 Primary Antibody für IHC, WB - ABIN2776715 : Dufourcq, Leroux, Ezan, Descamps, Lamazière, Costet, Basoni, Moreau, Deutsch, Couffinhal, Duplàa: Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation. in The American journal of pathology 2008 (PubMed)
    Zeige alle 4 Referenzen für 2776715

  3. Human Monoclonal FZD4 Primary Antibody für FACS, ICC - ABIN4900303 : Baksh, Boland, Tuan: Cross-talk between Wnt signaling pathways in human mesenchymal stem cells leads to functional antagonism during osteogenic differentiation. in Journal of cellular biochemistry 2007 (PubMed)
    Zeige alle 2 Referenzen für 4900303

  4. Human Polyclonal FZD4 Primary Antibody für ELISA, WB - ABIN408660 : You, Nguyen, Albers, Lin, Holcombe: Wnt pathway-related gene expression in inflammatory bowel disease. in Digestive diseases and sciences 2008 (PubMed)

  5. Human Monoclonal FZD4 Primary Antibody für FACS, ICC - ABIN4898976 : Despeaux, Chicanne, Rouer, De Toni-Costes, Bertrand, Mansat-De Mas, Vergnolle, Eaves, Payrastre, Girault, Racaud-Sultan: Focal adhesion kinase splice variants maintain primitive acute myeloid leukemia cells through altered Wnt signaling. in Stem cells (Dayton, Ohio) 2012 (PubMed)

Weitere Antikörper gegen FZD4 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Frizzled Family Receptor 4 (FZD4) Interaktionspartner

  1. Knockdown of Tc-fz1 alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 (zeige FZD2 Antikörper) or Tc-fz4 RNAi knockdowns.

Human Frizzled Family Receptor 4 (FZD4) Interaktionspartner

  1. Study shows that WNT5A (zeige WNT5A Antikörper) stimulates dimerization of membrane-anchored FZD4 CRDs and oligomerization of full-length FZD4, which requires the integrity of CRD (zeige CRX Antikörper) palmitoleoyl-binding residues. These results suggest that FZD receptors may form signalosomes in response to Wnt (zeige WNT2 Antikörper) binding through the CRDs and that the Wnt (zeige WNT2 Antikörper) palmitoleoyl group is important in promoting these interactions.

  2. FZD4 down-regulation leads to loss of WNT (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signal activity and subsequently to reduced alveolar epithelial cell wound repair capacity and impaired expression of elastogenic components.

  3. his study showed that Let7b modulates the proliferation, invasiveness, and migration of liver cancer cell and reduces the proportion of cancer stem cells in liver cancer cell by inhibiting Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway via downregulated Frizzled4.

  4. Among the detected mutations, LRP5 (zeige LRP5 Antikörper) accounted for the largest proportion with a mean mutation rate of 16.1% (5/31, 16.1%), followed by NDP (zeige NDP Antikörper) (3/31, 9.7%), FZD4 (2/31, 6.5%), TSPAN12 (zeige TSPAN12 Antikörper) (1/31, 3.2%), and KIF11 (zeige KIF11 Antikörper) (1/31, 3.2%). All the novel changes were predicted to be pathogenic by a series of bioinformatics analyses.

  5. human FZD4 assembles-in a DVL-independent manner-with Galpha12/13 but not representatives of other heterotrimeric G protein subfamilies.

  6. Several novel mutations (missense, non-stop (zeige USP22 Antikörper) and insertion) were detected in the coding regions of FZD4, TSPAN12 (zeige TSPAN12 Antikörper) and ZNF408 (zeige ZNF408 Antikörper) genes among the unrelated familial exudative vitreoretinopathy probands. The mutations in FZD4 and TSPAN12 (zeige TSPAN12 Antikörper) were involved in autosomal dominant and autosomal recessive families and further validates the involvement of these gene in exudative vitreoretinopathy development.

  7. Two were novel mutations: p.E134* and p.T503fs of FZD4 lead to the loss of FZD4 activity.

  8. Letter: FZD4+ and FZD4- melanocytes were significantly lower in hair follicles of patients with rhododenol-induced leukoderma.

  9. These structural, biophysical and cellular data, map Fz4 and putative Lrp5 (zeige LRP5 Antikörper)/6 binding sites to distinct patches on Norrin (zeige NDP Antikörper), and reveal a GAG binding site spanning Norrin (zeige NDP Antikörper) and Fz4 cysteine-rich domain.

  10. The relatively high prevalence of the p.[P33S(;)P168S] variant in ROP (zeige STXBP1 Antikörper) (retinopathy of prematurity) and intrauterine growth restriction suggests that it also may be a marker for increased risk of developing ROP (zeige STXBP1 Antikörper) and preterm birth.

Xenopus laevis Frizzled Family Receptor 4 (FZD4) Interaktionspartner

  1. A splice variant of the Frizzled-4 receptor modulates Wnt (zeige WNT2 Antikörper) signalling in a dose-dependent, biphasic manner.

Mouse (Murine) Frizzled Family Receptor 4 (FZD4) Interaktionspartner

  1. Fzd4 and Fzd6 (zeige FZD6 Antikörper) genes have a deep patterning effect on arterial vessel morphogenesis that may determine its functional efficiency

  2. Study identified a novel Wnt5a (zeige WNT5A Antikörper)/Fzd4 signaling pathway that contributes to the regulation of dendrite morphogenesis

  3. These results question the conclusion that a dominant-negative mechanism would explain the dominance of the mutant L501fsX533 Fz4 allele in the transmission of a form of Familial exudative vitreoretinopathy.

  4. The data reveal both cell-autonomous and cell-nonautonomous effects, and they imply a central role for Norrin (zeige NDP Antikörper)/Fz4 signaling in central nervous system vascular development and in the maintenance of the blood brain barrier/blood retina barrier state.

  5. Frizzled 4 regulates arterial network organization through noncanonical Wnt (zeige WNT2 Antikörper)/planar cell polarity signaling.

  6. Frizzled4 wnt (zeige WNT2 Antikörper) receptors are significantly increased in pathological neovascularization in a mouse model of oxygen-induced proliferative retinopathy.

  7. targeted inactivation of the TSK (zeige FBN1 Antikörper) gene in mice causes expansion of the ciliary body and up-regulation of Wnt2b (zeige WNT2B Antikörper) and Fzd4 expression in the developing peripheral eye

  8. These results demonstrate that FZD4 is required for physiological and pathologic angiogenesis in the retina and for regulation of retinal endothelial cell differentiation.

  9. A major role for frizzled 4 and frizzled 8 (zeige FZD8 Antikörper) in controlling ureteric growth in the developing kidney.

  10. a Norrin (zeige NDP Antikörper)-Fz4 signaling system plays a central role in vascular development in the eye and ear, and ligands unrelated to Wnts can act through Fz receptors

FZD4 Antigen-Profil

Beschreibung des Gens

This gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This protein may play a role as a positive regulator of the Wingless type MMTV integration site signaling pathway. A transcript variant retaining intronic sequence and encoding a shorter isoform has been described, however, its expression is not supported by other experimental evidence.

Alternative names and synonyms associated with FZD4

  • frizzled 4 (fz4) Antikörper
  • frizzled homolog 4 (fzd4) Antikörper
  • frizzled-4 (Tsp_10376) Antikörper
  • frizzled family receptor 4 (FZD4) Antikörper
  • frizzled family receptor 4 (Fzd4) Antikörper
  • frizzled family receptor 4 (fzd4) Antikörper
  • frizzled homolog 4 (Drosophila) (Fzd4) Antikörper
  • anon-WO0170980.10 Antikörper
  • anon-WO0170980.11 Antikörper
  • CD344 Antikörper
  • CG4626 Antikörper
  • Dfz4 Antikörper
  • Dmel\\CG4626 Antikörper
  • Dm Fz4 Antikörper
  • EVR1 Antikörper
  • FEVR Antikörper
  • frizzled4 Antikörper
  • FZ-4 Antikörper
  • fz1 Antikörper
  • fz4 Antikörper
  • FZD4S Antikörper
  • FzE4 Antikörper
  • GPCR Antikörper
  • hFz4 Antikörper
  • zg01 Antikörper

Bezeichner auf Proteinebene für FZD4

CG4626-PA , CG4626-PB , fz4-PA , fz4-PB , frizzled homolog 1 , frizzled-4 , frizzled homolog 4 , WNT receptor frizzled-4 , frizzled 4, seven transmembrane spanning receptor , frizzled receptor 4 , fz-4 , rFz4 , frizzled 4 protein , xfz4 , cFz-4 , mFz4

GENE ID SPEZIES
31659 Drosophila melanogaster
30363 Danio rerio
10902349 Trichinella spiralis
100231781 Taeniopygia guttata
8322 Homo sapiens
64558 Rattus norvegicus
399192 Xenopus laevis
373887 Gallus gallus
485149 Canis lupus familiaris
14366 Mus musculus
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