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Human CTHRC1 Protein expressed in Human Cells - ABIN2004469
Pyagay, Heroult, Wang, Lehnert, Belden, Liaw, Friesel, Lindner: Collagen triple helix repeat containing 1, a novel secreted protein in injured and diseased arteries, inhibits collagen expression and promotes cell migration. in Circulation research 2005
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Expression of CTHRC1 was significantly higher in Wilms' tumor compared to the expression in the adjacent non-cancerous tissues. High tumor expression of CTHRC1 was associated with tumor size, clinical stage, histopathological type, and vascular invasion/metastasis. Patients with high CTHRC1 expression also exhibited a shorter survival.
CTHRC1 expression is significantly upregulated in human masticatory mucosa during wound healing.
CTHRC1 downregulation inhibited proliferation.
The knockdown of CTHRC1 exerts inhibitory effects on the proliferation and migration ability of glioblastoma cells.
CTHRC1 may play a role in the progression of ovarian cancer.
this study shows that the serum CTHRC1 level was significantly higher in the influenza A virus infection patients than in the healthy individuals; the influenza A virus non-structural protein NS1 (zeige PTPN11 Proteine) upregulates the expression of CTHRC1 protein
Gene expression levels of three randomly selected DEGs (zeige DEGS1 Proteine), VCAN (zeige Vcan Proteine), COL5A1 and KCNJ16 (zeige KCNJ16 Proteine), were examined using RT-PCR in 10 ATC (zeige SRPK1 Proteine) samples.. angiogenesis was activated by the high expression of CTHRC1, VCAN (zeige Vcan Proteine) and POSTN (zeige POSTN Proteine), providing necessary nutrition for tumor cells
increased CTHRC1 expression is associated with advanced TNM (zeige ODZ1 Proteine) stage, increased LN metastasis and tumor size, and decreased OS and DFS (zeige FST Proteine), indicating that CTHRC1 may be a biomarker for prognosis of cancer patients
High CTHRC1 expression is associated with Osteosarcoma.
Authors showed that ectopic transfection of CTHRC1 in EOC cells up-regulated the expression of EMT (zeige ITK Proteine) markers such as N-cadherin (zeige CDH2 Proteine) and vimentin (zeige VIM Proteine), and EMT (zeige ITK Proteine)-associated transcriptional factor Snail (zeige SNAI1 Proteine).
CTHRC1 is an osteoclast-secreted coupling factor that regulates bone remodeling.
This study demonstrated that Cthrc1 plays a negative regulatory role, fine-tuning the onset of peripheral myelination.
this is the first demonstration of Cthrc1 as a marker of the severity of the disease progression in the dystrophic muscles.
Hormonal functions of Cthrc1 include regulation of lipid storage and cellular glycogen (zeige GYS1 Proteine) levels with potentially broad implications for cell metabolism and physiology.
Data show a dramatic discrepancy between ROSA26 reporter activity and Pdgfrb (zeige PDGFRB Proteine) promoter driven Cre dependent myc (zeige MYC Proteine)-tagged Cthrc1 transgene expression.
Downregulated by dietary beta-carotene in lungs of knockout Bcmo1 (zeige BCMO1 Proteine)-deficient mice.
Cthrc1 expression overlaps considerably with those reported for TGF-beta (zeige TGFB1 Proteine) family members and interstitial collagens.
Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex.
Cthrc1 increases bone mass as a positive regulator of osteoblastic bone formation
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described.
collagen triple helix repeat containing 1
, collagen triple helix repeat-containing protein 1