CTHRC1 Protein (AA 31-243) (His tag)

Produktnummer ABIN1880698

Produktdetails

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Protein-Typ: Recombinant

Proteineigenschaft: AA 31-243

Spezies: Human

Quelle: Human Cells

Aufreinigungstag / Konjugat: Dieses CTHRC1 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Human CTHRC1/NMTC1 (C-6His)

Sequenz: SEIPKGKQKA QLRQREVVDL YNGMCLQGPA GVPGRDGSPG ANGIPGTPGI PGRDGFKGEK GECLRESFEE SWTPNYKQCS WSSLNYGIDL GKIAECTFTK MRSNSALRVL FSGSLRLKCR NACCQRWYFT FNGAECSGPL PIEAIIYLDQ GSPEMNSTIN IHRTSSVEGL CEGIGAGLVD VAIWVGTCSD YPKGDASTGW NSVSRIIIEE LPKVDHHHHH H

Produktmerkmale: Recombinant Human Collagen triple helix repeat-containing protein 1/CTHRC1 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Ser31-Lys243) of Human CTHRC1 fused with a polyhistidine tag at the C-terminus.

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handhabung: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Lagerung: 4 °C/-20 °C/-80 °C

Informationen zur Lagerung: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Antigendetails

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Andere Bezeichnung: CTHRC1 (CTHRC1 Produkte)

Synonyme: CTHRC1 Protein, cthrc1 Protein, zgc:101075 Protein, 1110014B07Rik Protein, collagen triple helix repeat containing 1 Protein, collagen triple helix repeat containing 1a Protein, CTHRC1 Protein, cthrc1 Protein, cthrc1a Protein, Cthrc1 Protein

Hintergrund: Collagen triple helix repeat-containing protein 1 is a protein that in humans is encoded by the CTHRC1 gene. It acts as a negative regulator of collagen matrix deposition. It may cause the disease of Barrett esophagus . Patients with Barrett esophagus have an increased risk of esophageal adenocarcinoma. The main cause of Barrett esophagus is gastroesophageal reflux. The retrograde movement of acid and bile salts from the stomach into the esophagus causes prolonged injury to the esophageal epithelium and induces chronic esophagitis, which in turn is believed to trigger the pathologic changes.

Molekulargewicht: 24.1 kDa

UniProt: Q96CG8

Pathways: Tube Formation