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Transferrin Receptor 2 Proteine (TFR2)

Bezeichnung:
Transferrin Receptor 2 Proteine (TFR2)
Auf www.antikoerper-online.de finden Sie aktuell 16 Transferrin Receptor 2 (TFR2) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Transferrin Receptor 2 Antikörper (65) und Transferrin Receptor 2 Kits (45) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 131 Transferrin Receptor 2 Produkte verfügbar.
Synonyme:
HFE3, TFR2, TFRC2, Trfr2, zgc:123043
alle Proteine anzeigen Gen GeneID UniProt
TFR2 50765 Q9JKX3
TFR2 7036 Q9UP52
TFR2 288562 B2GUY2

Weitere Synonyme anzeigen

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Mouse (Murine) Transferrin Receptor 2 (TFR2) Interaktionspartner

  1. These studies further elucidate the role of TFR2 in the regulation of iron homeostasis and its role in regulation of ferroportin (zeige SLC40A1 Proteine) and thus macrophage iron homeostasis

  2. Tfr2 is a novel target gene for HNF4alpha (zeige HNF4A Proteine), and hepatic HNF4alpha (zeige HNF4A Proteine) plays a critical role in iron homeostasis.

  3. There is an essential role for TFR2 in erythropoiesis that may provide new targets for the treatment of anaemia.

  4. We suggest that Tfr2 is a component of a novel iron-sensing mechanism that adjusts erythrocyte production according to iron availability, likely by modulating the erythroblast Epo (zeige EPO Proteine) sensitivity.

  5. We propose that TFR2 is a limiting factor for erythropoiesis, particularly in conditions of iron restriction.

  6. These results support in vivo studies which suggest that Hfe (zeige HFE Proteine) and Tfr2 can independently regulate hepcidin (zeige HAMP Proteine).

  7. we used microarray and real-time reverse transcription polymerase chain reaction to assess brain transcriptome profiles of transferrin receptor 2 mutant mice a model of a rare type of hereditary hemochromatosis (zeige HFE Proteine)

  8. Double mutant mice lacking functional Hfe (zeige HFE Proteine) or Tfr2 and Tmprss6 (zeige TMPRSS6 Proteine) exhibited a severe iron deficiency microcytic anemia phenotype mimicking the phenotype of single mutant mice lacking functional Tmprss6 (zeige TMPRSS6 Proteine) demonstrating that Hfe (zeige HFE Proteine) and Tfr2 are not substrates for Tmprss6 (zeige TMPRSS6 Proteine).

  9. Disruption of both Hfe (zeige HFE Proteine) and Tfr2 caused more severe hepatic iron overload with more advanced lipid peroxidation, inflammation, and portal fibrosis than was observed with the disruption of either gene alone.

  10. Tfr2 is not essential for Hfe (zeige HFE Proteine)-mediated induction of hepcidin (zeige HAMP Proteine) expression, supporting the possibility that TFR2 may regulate iron metabolism in an HFE (zeige HFE Proteine)-independent manner.

Human Transferrin Receptor 2 (TFR2) Interaktionspartner

  1. In line with a status of iron deficiency, gene expression studies suggested decreased expression of transferrin (zeige Tf Proteine) and transferrin receptor 2 in non-alcoholic steatohepatitis livers

  2. Our results indicate that membrane transferrin receptor-2, a sensor of circulating iron, is released from the cell membrane in iron deficiency.

  3. results suggest that down-regulation of CD81 (zeige CD81 Proteine) by GRAIL (zeige RNF128 Proteine) targets TfR2 for degradation

  4. Polymorphisms of the TRF2 (zeige TERF2 Proteine) gene may be associated with age-related macular degeneration occurrence, either directly or by modulation of risk factors.

  5. The variants of rs2075674 and rs7385804 in TFR2 gene were not associated with coronary heart disease risk in a Chinese Han population.

  6. Present findings support the hypothesis of a main role of the TFR2 gene in HH pathogenesis in those regions, such as Central-Southern Italy, where the p.C282Y frequency is low.

  7. Authors investigated the expression of TfR1 (zeige TFRC Proteine) and TfR2 in human HCC (zeige FAM126A Proteine) tissues by immunohistochemistry, the first report demonstrating TfR2 expression immunohistochemically in human HCC (zeige FAM126A Proteine).

  8. N-linked glycosylation is dispensable for the cell surface expression and holo-Tf binding, but it is required for efficient intersubunit disulfide bond formation and holo-Tf-induced stabilization of TfR2.

  9. Studies indicate that several genes have been linked to iron homeostasis, including transferrin (zeige Tf Proteine) (TF), iron regulatory protein 1 (ACO1 (zeige ACO1 Proteine)) and transferrin receptor 2 (TFR2).

  10. The hemochromatosis (zeige HFE Proteine) proteins HFE (zeige HFE Proteine), TfR2, and HJV (zeige HFE2 Proteine) form a membrane-associated protein (zeige PDZK1IP1 Proteine) complex for hepcidin (zeige HAMP Proteine) regulation.

Cow (Bovine) Transferrin Receptor 2 (TFR2) Interaktionspartner

  1. One novel SNPs was identified in TFR2 which tended to be associated (P < 0.013) with skeletal muscle iron content.

Zebrafish Transferrin Receptor 2 (TFR2) Interaktionspartner

  1. TfR2 is coexpressed with transferrin-a (zeige Tf Proteine) in the liver of the zebrafish embryo. Knockdown of TfR2 fails to produce anemia or a morphologic defect.

Transferrin Receptor 2 (TFR2) Protein Überblick

Protein Überblick

This gene encodes a single-pass type II membrane protein, which is a member of the transferrin receptor-like family. This protein mediates cellular uptake of transferrin-bound iron, and may be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative names and synonyms associated with Transferrin Receptor 2 (TFR2)

  • transferrin receptor 2 (TFR2)
  • transferrin receptor 2 (Tfr2)
  • transferrin receptor 2 (tfr2)
  • HFE3 Protein
  • TFR2 Protein
  • TFRC2 Protein
  • Trfr2 Protein
  • zgc:123043 Protein

Bezeichner auf Proteinebene für Transferrin Receptor 2 Proteine (TFR2)

transferrin receptor 2 , transferrin receptor protein 2-like , transferrin receptor protein 2

GENE ID SPEZIES
463605 Pan troglodytes
719240 Macaca mulatta
100395993 Callithrix jacchus
100457089 Pongo abelii
100466518 Ailuropoda melanoleuca
50765 Mus musculus
7036 Homo sapiens
288562 Rattus norvegicus
100712922 Cavia porcellus
100517580 Sus scrofa
489834 Canis lupus familiaris
617916 Bos taurus
100357314 Oryctolagus cuniculus
494476 Danio rerio
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