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Transferrin Receptor 2 Protein (TFR2) (AA 103-798) (Fc Tag)

TFR2 Spezies: Maus Wirt: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
Produktnummer ABIN4949192
  • Target Alle Transferrin Receptor 2 (TFR2) Proteine anzeigen
    Transferrin Receptor 2 (TFR2)
    Protein-Typ
    Recombinant
    Proteineigenschaft
    AA 103-798
    Spezies
    • 7
    • 5
    • 2
    Maus
    Quelle
    • 7
    • 4
    • 2
    • 1
    HEK-293 Cells
    Aufreinigungstag / Konjugat
    Dieses Transferrin Receptor 2 Protein ist gelabelt mit Fc Tag.
    Applikation
    Functional Studies (Func)
    Sequenz
    AA 103-798
    Produktmerkmale
    This protein carries a mouse IgG1 Fc tag at the N-terminus, and has a calculated MW of 103.2 kDa. The predicted N-terminus is Ile. The reducing (R) protein migrates as 116 kDa in SDS-PAGE due to glycosylation.
    Reinheit
    >95 % as determined by SDS-PAGE.
    Endotoxin-Niveau
    Less than 0.1 EU per μg by the LAL method.
    Top Product
    Discover our top product TFR2 Protein
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Buffer
    Tris with Glycine, Arginine and NaCl,  pH 7.5
    Handhabung
    Please avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
  • Stocki, Szary, Rasmussen, Demydchuk, Northall, Logan, Gauhar, Thei, Moos, Walsh, Rutkowski: "Blood-brain barrier transport using a high affinity, brain-selective VNAR antibody targeting transferrin receptor 1." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 35, Issue 2, pp. e21172, (2021) (PubMed).

  • Target
    Transferrin Receptor 2 (TFR2)
    Andere Bezeichnung
    Transferrin R2 (TFR2 Produkte)
    Synonyme
    TFR2 Protein, Trfr2 Protein, HFE3 Protein, TFRC2 Protein, zgc:123043 Protein, transferrin receptor 2 Protein, TFR2 Protein, Tfr2 Protein, tfr2 Protein
    Hintergrund
    Transferrin receptor protein 2 (TFR2) is a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. The mutations in TFR2 gene have been associated with hereditary hemochromatosis type III. Furthermore, TFR2 is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.
    Molekulargewicht
    101.1 kDa
    NCBI Accession
    NP_056614
    UniProt
    Q9JKX3
    Pathways
    Transition Metal Ion Homeostasis
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